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FOLATES, COMPOSITIONS AND USES THEREOF
No full textThe present invention relates to folates, compositions and uses thereof, in particular, the invention describes a crystalline or amorphous compound which is unsubstituted folate or reduced folate, or the natural or unatural isomers thereof, of at least one organic base, as well ac compositions and uses thereof. The compounds of the invention show a long lasting stability as well as a peculiarly high water-solubility
Process for the diastereoisomeric resolution of 5-Methyltetrahydrofolic acid
No full textThe invention relates to a process for the distereoisomeri resolution of 5-Methyltetrahydrofolic acid; it discloses also a cristalline amine salt of 5-Methyltetrahydrofolic acid and is furthe directed to a process for the transformation of the single diastereoisomers of the 5-Methyltetrahydrofolic amine salts obtained by the process of the invnetion into the corresponding free acid or into an alkaline earth matal salt. The inventio provides a simple, economically advantageous and efficient process and allows to obtain stable and pure (6R) and (6S)- diastereoisomers of 5-Methyltetrahydrofolic acid in good yield and diastereoisomeric putity
Shark-like chondroitin sulfate and process for the preparation thereof
No full textThe present invention concerns a shark-like chondroitin sulfate and a process for the prepn. thereof. In particular, the present invention relates to a shark-like chondroitin sulfate having a very low amt. of 4-sulfate, a high charge d. and a biol. activity comparable to natural chondroitin sulfates. The invention also relates to a process for the prepn. of said shark-like chondroitin sulfate affording substantially higher productivities and better reproducibility of product quality. The shark-like chondroitin sulfate of the invention shows a high mol. mass and charge d. and in vitro biol. and anti-inflammatory effectiveness, comparable to the ones of natural products make this polysaccharide potentially useful as a drug in pharmaceutical prepns. and nutraceuticals. Chondroitin sulfate was obtained by the reaction of sodium chondroitin with sulfur trioxide pyridine comple
Biotechnologica sulphated chondroitin sulphate at position 4 or 6 on the same polysaccharide chain, and process for the preparation thereof
No full textThe present invention disclosed a process for the production of chondroitin sulphated with an average molecular weigh (Mw) of 10-30 KDa by chemical sulphation starting from an unsulphated backbone, obtained in turan by acidc hydrolisis of capsular polysaccarides K4 made directly from E. coli strai O5:K4:H14, ordirectly produced from a genetically modified strain of E. coli. Sulphatetion of N-acetil-D-galactosamine residue at position 4 or 6 takes place simultaneously in the same plisaccharide chain, simulating the sulphation pattern observed in natural chondroitin sulphate, unlike the sukphation obtained with the synthesis methods described to date
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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