511 research outputs found
Effects of aerobic exercise training in children after the Fontan operation
No full textAm J Cardiol. 2005 Jan 1;95(1):150-2.
Effects of aerobic exercise training in children after the Fontan operation.
Opocher F, Varnier M, Sanders SP, Tosoni A, Zaccaria M, Stellin G, Milanesi O.
Source
Department of Pediatrics, Medical and Surgical Sciences, University of Padova, School of Medicine, Padova, Italy.
Abstract
It was demonstrated that patients who have undergone the Fontan operation can safely undertake exercise training and that this results in an improvement in aerobic capacity. These findings suggest that aerobic training could be useful in the long-term management of these patients to optimize their cardiovascular fitness for more active lives.
PMID:
15619417
[PubMed - indexed for MEDLINE
Introduction: Manufacturing knowledge at the border of science
No full textThis book focuses on a timely and currently highly controversial topic with considerable resonance in academic circles, amongst policymakers and in the broader public sphere. The central research question it explores is: How and under which conditions do groups of people assign credibility and trust to knowledge claims located outside the established boundaries of science
Improvement of P.M. stepping motor performances by the modification of system parameters with active impedance
No full textEtnografia virtuale e convergenza. Spazi, tempi, discorsi e pratiche della tv sul web
No full textUna trattazione approfondita delle questioni teoriche, metodologiche e operative che riguardano la virtual ethnography negli spazi online legati a programmi, reti e offerte televisive
Convergenza ed etnografia di rete. La virtual ethnography del consumo televisivo
No full textUna ricognizione sulla virtual ethnography di prodotti televisivi e sui vantaggi e svantaggi di questo metodo di indagine
An algorithm for the analysis of the dynamic of rotating electrical machines with ring and bar commutator windings
No full textTOSONI DINA
No full textIl ritratto di una docente preparata che appartenne al gruppo di maestre dell'Anconetano che, il 25 luglio 1906, in forza della cosiddetta "sentenza Mortara", divennero le prime elettrici della storia italiana ed europea
Direct contribution of epithelium to organ fibrosis : epithelial-mesenchymal transition
No full textFibrosis of epithelial parenchymal organs and end-stage organ failure represent the final common pathway of many chronic diseases and are a major determinant of morbidity and mortality worldwide. Fibrosis is a complex response initiated to protect the host from an injurious event; nevertheless, it leads to serious organ damage when it becomes independent from the initiating stimulus. It involves massive deposition of matrix by an expanded pool of fibrogenic cells, disruption of the normal tissue architecture, and parenchymal destruction. Fibroblasts, the effector cells of matrix production, when engaged in fibrogenesis, display the highly activated phenotype characteristic of myofibroblasts. These cells are present in a large number in sites with ongoing inflammation, reparative reaction, and fibrosis, but their origin has not yet been definitely elucidated. Although proliferation of preexisting stromal fibroblasts and, probably, recruitment of bone marrow-derived fibrogenic cells may account for a portion of them, emerging evidence seems to indicate that an important number of matrix-producing fibroblasts/myofibroblasts arises through a mechanism of epithelial-mesenchymal transition. Through this process, epithelial cells would lose intercellular cohesion and would translocate from the epithelial compartment into the interstitium where, gaining a full mesenchymal phenotype, they could participate in the synthesis of the fibrotic matrix. Epithelial-mesenchymal transition is induced by the integrated actions of many stimuli including transforming growth factor-beta and matrix-generated signals that are also known to be implicated in inflammation, repair responses, and fibrosis. The consequences of epithelial-mesenchymal transition in chronic fibrosing diseases could be two-fold as follows: on one hand, by supplementing new mesenchymal cells, it might feed the expanding pool of interstitial fibroblasts/myofibroblasts responsible for the matrix accumulation; on the other hand, it could cause loss of epithelial cells, thus, contributing to the parenchyma destruction seen in advanced fibrosis. Markers of epithelium undergoing epithelial-mesenchymal transition include loss of E-cadherin and cytokeratin; de novo expression of fibroblast-specific protein 1/S100A4, vimentin, and alpha-smooth muscle actin; basement membrane component loss; and production of interstitial-type matrix molecules such as fibronectin and type I/III collagen. Evidence of epithelial-mesenchymal transition has been reported in the kidney, lung, liver, eye, and serosal membranes suggesting that epithelial-mesenchymal transition could be involved in the pathogenesis of fibrotic disorders in these organs. Thus, because of its fibrogenic potential, the detection of epithelial-mesenchymal transition in biopsy specimens could be useful diagnostically and represent a new biomarker of progression in chronic fibrosing diseases
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