1,720,979 research outputs found
Atypical cutaneous metastases from signet-ring cell gastric carcinoma
No full textThe authors describe a case of atypical cutaneous metastases from a signet-ring cell gastric carcinoma. Skin manifestations (diffuse erythemato-oedematous and infiltrating lesions on the neck, shoulders, arms and chest) appeared five years after surgical removal of the primary tumour. Histopathological examination revealed neoplastic emboli within the dermal blood and lymphatic vessels consisting of typical signet-ring cells
A NANOTECHNOLOGY APPROACH FOR GLIOBLASTOMA TARGETED THERAPY
Full text linkGlioblastoma multiforme (GBM) is an extremely aggressive type of glioma. Life expectancy is around two years after diagnosis, due to recidivism and to the presence of the blood brain barrier (BBB) restricting the amount of drugs which arrive at the residual cancer cells, thus contributing to chemotherapies failure. To overcome the impediment imposed by the BBB, we have investigated the use of nanotechnologies in synergy with radiotherapy as a prospective strategy for GBM treatment. We have used poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PNP) conjugated to the peptide chlorotoxin (CTX), which has been shown to recognize and selectively bind to glioma cells. Silver nanoparticles have been encapsulated inside the functionalized nanoparticles (Ag-PNP-CTX), to allow detection of cellular uptake and quantification by means of confocal microscopy, both in vitro and in vivo. In vitro experiments, involving 3 different human glioblastoma cell lines, have shown that the cytoplasmic uptake of Ag-PNP-CTX is higher than that of non-functionalized nanoparticles. Experiments performed in vivo have shown high efficiency of Ag-NP-CTX particles in targeting tumor cells; however, they have been shown to be scarcely able to cross the blood brain barrier at the healthy brain level, where scattered metastatic cells are present too. A single x-rays administration on the whole brain, carried out twenty hours before the injection of the nanoparticles, has been shown to increase the levels of expression of the CTX targets MMP-2 e ClC-3. Moreover, through an alteration of BBB permeability, it has been shown to potentially increase the quantity of internalized Ag-PNP-CTX also in dispersed cells, and to lead to significant results in inhibiting tumor growth in vivo. Notably, the administration of Ag-PNP-CTX to irradiated tumor cells decreases the MMP-2 extracellular activity. By targeting scattered GBM cells and limiting MMP-2 activity, the synergic use of nanovectors conjugated with CTX and radiotherapy may represent an efficient therapeutic approach to GBM treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
A guided inquiry based teaching and learning sequence on oscillations based on experiments and data-logging techniques
Full text linkWe present here a teaching and learning sequence on oscillations entirely based on
experiments and data logging techniques. The sequence has been proposed to three
different groups of students during curricular and extracurricular lessons. The purpose of
this paper is to discuss a way to introduce upper secondary school students to complicated
topics, such as those of coupled oscillations, avoiding the use of too much mathematics and
calculus, but with an intense use of data logging techniques
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