34 research outputs found
Un manager in tribunale. Costi e tempi della giustizia civile : analisi economica, riforme, strumenti alternativi
No full textTrehalose counteracts the dissociation of tetrameric rabbit lactate dehydrogenase induced by acidic pH conditions
No full textThe lactate dehydrogenase from rabbit skeletal muscle (rbLDH) is a tetrameric enzyme, known to undergo dissociation when exposed to acidic pH conditions. Moreover, it should be mentioned that this dissociation translates into a pronounced loss of enzyme activity. Notably, among the compounds able to stabilize proteins and enzymes, the disaccharide trehalose represents an outperformer. In particular, trehalose was shown to efficiently counteract quite a number of physical and chemical agents inducing protein denaturation. However, no information is available on the effect, if any, exerted by trehalose against the dissociation of protein oligomers. Accordingly, we thought it of interest to investigate whether this disaccharide is competent in preventing the dissociation of rbLDH induced by acidic pH conditions. Further, we compared the action of trehalose with the effects triggered by maltose and cellobiose. Surprisingly, both these disaccharides enhanced the dissociation of rbLDH, with maltose being responsible for a major effect when compared to cellobiose. On the contrary, trehalose was effective in preventing enzyme dissociation, as revealed by activity assays and by Dynamic Light Scattering (DLS) experiments. Moreover, we detected a significant decrease of both K0.5 and Vmax when the rbLDH activity was tested (at pH 7.5 and 6.5) as a function of pyruvate concentration in the presence of trehalose. Further, we found that trehalose induces a remarkable increase of Vmax when the enzyme is exposed to pH 5. Overall, our observations suggest that trehalose triggers conformational rearrangements of tetrameric rbLDH mirrored by resistance to dissociation and peculiar catalytic features
PATTERNS OF LEFT-VENTRICULAR HYPERTROPHY AND GEOMETRIC REMODELING IN ESSENTIAL-HYPERTENSION
No full textThe spectrum of left ventricular geometric adaptation to hypertension was investigated in 165 patients with untreated essential hypertension and 125 age- and gender-matched normal adults studied by two-dimensional and M-mode echocardiography. Among hypertensive patients, left ventricular mass index and relative wall thickness were normal in 52%, whereas 13% had increased relative wall thickness with normal ventricular mass ("concentric remodeling"), 27% had increased mass with normal relative wall thickness (eccentric hypertrophy) and only 8% had "typical" hypertensive concentric hypertrophy (increase in both variables). Systemic hemodynamics paralleled ventricular geometry, with the highest peripheral resistance in the groups with concentric remodeling and hypertrophy, whereas cardiac index was supernormal in those with eccentric hypertrophy and low normal in patients with concentric remodeling. The left ventricular short-axis/long-axis ratio was positively related to stroke volume (r = 0.45, p < 0.001), with cavity shape most elliptic in patients with concentric remodeling and most spheric in those with eccentric hypertrophy. Normality of left ventricular mass in concentric remodeling appeared to reflect offsetting by volume "underload" of the effects of pressure overload, whereas eccentric hypertrophy was associated with concomitant pressure and volume overload Thus, arterial hypertension is associated with a spectrum of cardiac geometric adaptation matched to systemic hemodynamics and ventricular load. Concentric left ventricular remodeling and eccentric hypertrophy are more common than the typical pattern of concentric hypertrophy in untreated hypertensive patients
Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension.
No full textThe spectrum of left ventricular geometric adaptation to hypertension was investigated in 165 patients with untreated essential hypertension and 125 age- and gender-matched normal adults studied by two-dimensional and M-mode echocardiography. Among hypertensive patients, left ventricular mass index and relative wall thickness were normal in 52%, whereas 13% had increased relative wall thickness with normal ventricular mass ("concentric remodeling"), 27% had increased mass with normal relative wall thickness (eccentric hypertrophy) and only 8% had "typical" hypertensive concentric hypertrophy (increase in both variables). Systemic hemodynamics paralleled ventricular geometry, with the highest peripheral resistance in the groups with concentric remodeling and hypertrophy, whereas cardiac index was super-normal in those with eccentric hypertrophy and low normal in patients with concentric remodeling. The left ventricular short-axis/long-axis ratio was positively related to stroke volume (r = 0.45, p less than 0.001), with cavity shape most elliptic in patients with concentric remodeling and most spheric in those with eccentric hypertrophy. Normality of left ventricular mass in concentric remodeling appeared to reflect offsetting by volume "underload" of the effects of pressure overload, whereas eccentric hypertrophy was associated with concomitant pressure and volume overload. Thus, arterial hypertension is associated with a spectrum of cardiac geometric adaptation matched to systemic hemodynamics and ventricular load. Concentric left ventricular remodeling and eccentric hypertrophy are more common than the typical pattern of concentric hypertrophy in untreated hypertensive patients
Feasibility and Safety of Using Carbon Dioxide Exclusively in Regular Endovascular Aortic Aneurysm Repair: Results of a Multicentre, Prospective, Zero Iodine Contrast Endovascular Aneurysm Repair Study
No full textObjective: Carbon dioxide (CO2) angiography has emerged as a viable alternative to regular iodinated contrast medium (ICM) for guiding endovascular aneurysm repair (EVAR) procedures. This study aimed to evaluate the feasibility and safety of a standardised EVAR procedure using only CO2 angiography. Methods: A prospective, multicentre, national study enrolled consecutive patients between January 2023 and January 2024 with asymptomatic abdominal aortic aneurysms measuring ≥ 55 mm and for whom a standard endovascular graft (instructions for use) was anatomically feasible. The study involved the use of an automatic CO2 injector to standardise intra-operative imaging. A strategy comprising five standardised steps was devised to visualise a target vessel (TV) that could not be seen during the first CO2 angiogram. The five steps were: (A) place the introducer closer to the TV; (B) tilt the table by 5 – 10° in the direction opposite to the TV; (C) selectively cannulate the TV; (D) cannulate the contralateral gate (only for repositionable devices); CO2 angiography was repeated in steps 1 – 2; and (E) use ICM. Results: Two hundred and ninety-three patients were enrolled (10 centres), with a median age of 78 (interquartile range [IQR] 72, 83) years; 256 (87.4%) were male. The overall procedure time, fluoroscopy time, and injected CO2 volume were 90 (IQR 65, 125) minutes, 15 (IQR 10, 22) minutes, and 600 (IQR 400, 800) mL, respectively. The 30 day mortality, complication, and re-intervention rates were 0.3% (n = 1), 6.8% (n = 20), and 2.4% (n = 7), respectively. CO2 related adverse events were rare (1%; n = 3) and minor. A zero iodine contrast EVAR procedure was feasible in 240 (patients 81.9%). The five standardised steps were used extensively: step A, 170 procedures (58.0%); step B, 109 procedures (37.2%); step C, 21 procedures (7.2%); step D, 14 procedures (4.8%); and step E, 53 procedures (18.1%), with a median volume of 20 (IQR 10, 35) mL. Significant predictors for ICM use were aneurysm diameter > 70 mm and a lowermost renal artery positioned between 3 and 9 o'clock. Conclusion: This study demonstrated that the standardised zero iodine contrast EVAR protocol reported here is both safe and feasible and is applicable in 82% of consecutive non-selected patients. Limitations primarily arose from anatomical factors, and adjunctive standardised manoeuvres can effectively address these challenges in most cases
Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension.
No full textBACKGROUND: Increased thoracic ascending aortic stiffness is thought to contribute to concentric left ventricular hypertrophy and increased mortality, a pattern seen in hypertension. As such, aortic stiffness and increased left ventricular mass are candidates by which obesity increases cardiovascular risk. However, obesity is characterized predominantly by increased abdominal aortic stiffness and with eccentric left ventricular hypertrophy. METHODS: We aimed to establish whether or not, in addition to these changes, there is also an element of concentric remodeling in obesity that was predicted by ascending aortic stiffness. 301 subjects underwent cardiovascular magnetic resonance imaging to measure regional aortic distensibility and left ventricular morphology. To compare obesity with hypertension, subjects were separated into groups by hypertensive status and body mass index. RESULTS: In comparison to normotensive subjects, hypertension was linked with concentric remodeling (a 17% increase in left ventricular mass:volume ratio (LVM:VR), (p<0.001)) and reduced ascending aortic distensibility (by 64%,p<0.001). LVM:VR was negatively correlated with ascending aortic distensibility (R=-0.36,p<0.01). Obesity, in the absence of hypertension, was associated with elevated left ventricular mass when compared to normal weight normotensive subjects (by 27%, p<0.01), in an eccentric pattern with cavity dilatation (p<0.01). However, LVM:VR was also 14% larger than in normal weight normotensive subjects (p<0.01), indicative of additional concentric remodeling. LVM:VR in obesity was, however, not correlated with ascending aortic distensibility when adjusted for mean arterial pressure (R=-0.14,p<0.14). CONCLUSION: In summary, despite the predominantly eccentric pattern of left hypertrophy in obesity there is a concentric element of hypertrophy that, unlike in hypertension, is not linked to increased ascending aortic stiffness
Very high energy observations of the Seyfert galaxy NGC 4151 with MAGIC Indication of another gamma-ray obscured candidate neutrino source
No full textAbe, K. et al.--Full list of authors: Abe, K.; Abe, S.; Abhir, J.; Abhishek, A.; Acciari, V. A.; Aguasca-Cabot, A.; Agudo, I.; Aniello, T.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A.; Arcaro, C.; Arnesen, T. T. H.; Asano, K.; Babić, A.; Bakshi, C.; Barres de Almeida, U.; Barrio, J. A.; Barrios-Jiménez, L.; Batković, I.; Baxter, J.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Bernete, J.; Berti, A.; Besenrieder, J.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Bronzini, E.; Burelli, I.; Campoy-Ordaz, A.; Carosi, A.; Carosi, R.; Carretero-Castrillo, M.; Castro-Tirado, A. J.; Cerasole, D.; Ceribella, G.; Chai, Y.; Cifuentes, A.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Menezes, R.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Di Pierro, F.; Di Tria, R.; Di Venere, L.; Dinesh, A.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Eisenberger, L.; Elsaesser, D.; Escudero, J.; Fariña, L.; Foffano, L.; Font, L.; Fröse, S.; Fukazawa, Y.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giesbrecht Paiva, J. G.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Gradetzke, T.; Grau, R.; Green, D.; Green, J. G.; Günther, P.; Hadasch, D.; Hahn, A.; Hassan, T.; Heckmann, L.; Herrera Llorente, J.; Hrupec, D.; Imazawa, R.; Israyelyan, D.; Jahanvi, J.; Jiménez Martínez, I.; Jiménez Quiles, J.; Jormanainen, J.; Kankkunen, S.; Kayanoki, T.; Konrad, J.; Kouch, P. M.; Kubo, H.; Kushida, J.; Láinez, M.; Lamastra, A.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Lulić, L.; Lyard, E.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mangano, S.; Mannheim, K.; Marchesi, S.; Mariotti, M.; Martínez, M.; Maruševec, P.; Mas-Aguilar, A.; Mazin, D.; Menchiari, S.; Méndez Gallego, J.; Menon, S.; Miceli, D.; Miranda, J. M.; Mirzoyan, R.; Molero González, M.; Molina, E.; Mondal, H. A.; Moralejo, A.; Nakamori, T.; Nanci, C.; Neustroev, V.; Nickel, L.; Nievas Rosillo, M.; Nigro, C.; Nikolić, L.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Okumura, A.; Otero-Santos, J.; Paiano, S.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Peresano, M.; Persic, M.; Pihet, M.; Pirola, G.; Podobnik, F.; Prada Moroni, P. G.; Prandini, E.; Rhode, W.; Ribó, M.; Rico, J.; Sahakyan, N.; Saito, T.; Saturni, F. G.; Schmitz, K.; Schmuckermaier, F.; Schubert, J. L.; Schweizer, T.; Sciaccaluga, A.; Silvestri, G.; Simongini, A.; Sitarek, J.; Sliusar, V.; Sobczynska, D.; Stamerra, A.; Strišković, J.; Strom, D.; Strzys, M.; Suda, Y.; Tajima, H.; Takahashi, M.; Takeishi, R.; Temnikov, P.; Terauchi, K.; Terzić, T.; Teshima, M.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vazquez Acosta, M.; Ventura, S.; Verna, G.; Viale, I.; Vigliano, A.; Vigorito, C. F.; Visentin, E.; Vitale, V.; Vovk, I.; Walter, R.; Wersig, F.; Will, M.; Yamamoto, T.; Yeung, P. K. H.; Neronov, A.; Peretti, E.; Peron, G.Seyfert galaxies are emerging as a promising source class of high-energy neutrinos. The Seyfert galaxies NGC 4151 and NGC 1068 have respectively come up as the most promising counterparts of a 3σ and of a 4.2σ neutrino excesses detected by IceCube in the TeV energy range. Constraining the very high energy (VHE) emission associated with the neutrino signal is crucial to unveiling the mechanism and site of neutrino production. In this work, we present the first results of the VHE observations (∼29 hours) of NGC 4151 with the MAGIC telescopes. We detected no gamma-ray excess in the direction of NGC 4151, and we derived constraining upper limits on the VHE gamma-ray flux. The integral flux upper limit (at the 95% confidence level) above 200 GeV is f = 2.3 × 10−12 cm−2 s−1. Comparison of the MAGIC and IceCube measurements suggests the presence of a gamma-ray obscured accelerator, and it allowed us to constrain the gamma-ray optical depth and the size of the neutrino production site. © The Authors 2025.We would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the grants PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-104114RB-C33, PID2019-105510GB-C31, PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22, PID2022-136828NB-C41, PID2022-137810NB-C22, PID2022-138172NB-C41, PID2022-138172NB-C42, PID2022-138172NB-C43, PID2022-139117NB-C41, PID2022-139117NB-C42, PID2022-139117NB-C43, PID2022-139117NB-C44 funded by the Spanish MCIN/AEI/ 10.13039/501100011033 and “ERDF A way of making Europe”; the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also been supported by Centros de Excelencia “Severo Ochoa” y Unidades “María de Maeztu” program of the Spanish MCIN/AEI/ 10.13039/501100011033 (CEX2019-000920-S, CEX2019-000918-M, CEX2021-001131-S) and by the CERCA institution and grants 2021SGR00426 and 2021SGR00773 of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2022-10-4595 and the University of Rijeka Project uniri-prirod-18-48; by the Deutsche Forschungsgemeinschaft (SFB1491) and by the Lamarr-Institute for Machine Learning and Artificial Intelligence; by the Polish Ministry Of Education and Science grant No. 2021/WK/08; by the Brazilian MCTIC, the CNPq Productivity Grant 309053/2022-6 and FAPERJ Grants E-26/200.532/2023 and E-26/211.342/2021. E.P. was supported by Agence Nationale de la Recherche (grant ANR-21-CE31-0028) and by INAF through “Assegni di ricerca per progetti di ricerca relativi a CTA e precursori”. Author Contributions. A. Lamastra: project management, P.I. of MAGIC observations, MAGIC data analysis, theoretical interpretation, paper drafting; S. Mangano: MAGIC analysis cross-check, paper drafting; S. Menon: MAGIC data analysis, paper drafting; E. Peretti: P.I. theory, theoretical modeling and interpretation, paper drafting; G. Peron: Fermi-LAT data interpretation and paper drafting; F. G. Saturni: theoretical interpretation and paper drafting. The rest of the authors have contributed in one or several of the following ways: design, construction, maintenance and operation of the instrument(s) used to acquire the data; preparation and/or evaluation of the observation proposals; data acquisition, processing, calibration and/or reduction; production of analysis tools and/or related Monte Carlo simulations; overall discussions about the contents of the draft, as well as related refinements in the descriptions.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000918-M).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).Peer reviewe
Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
No full textThe spectrum of left ventricular geometric adaptation to hypertension was investigated in 165 patients with untreated essential hypertension and 125 age- and gender-matched normal adults studied by two-dimensional and M-mode echocardiography. Among hypertensive patients, left ventricular mass index and relative wall thickness were normal in 52%, whereas 13% had increased relative wall thickness with normal ventricular mass (“concentric remodeling”), 27% had increased mass with normal relative wall thickness (eccentric hypertrophy) and only 8% had “typical” hypertensive concentric hypertrophy (increase in both variables).
Systemic hemodynamics paralleled ventricular geometry, with the highest peripheral resistance in the groups with concentric remodeling and hypertrophy, whereas cardiac index was supernormal in those with eccentric hypertrophy and low normal in patients with concentric remodeling. The left ventricular shortaxis/long-axis ratio was positively related to stroke volume (r = 0.45, p < 0.001), with cavity shape most elliptic in patients with concentric remodeling and most spheric in those with eccentric hypertrophy. Normality of left ventricular mass in concentric remodeling appeared to reflect offsetting by volume “underload” of the effects of pressure overload, whereas eccentric hypertrophy was associated with concomitant pressure and volume overload.
Thus, arterial hypertension is associated with a spectrum of cardiac geometric adaptation matched to systemic hemodynamics and ventricular load. Concentric left ventricular remodeling and eccentric hypertrophy are more common than the typical pattern of concentric hypertrophy in untreated hypertensive patients
Testing the ubiquitous presence of very high energy emission in gamma-ray bursts with the MAGIC telescopes
No full textAbe, S. et al.-- Full list of authors: Ansoldi, , L. A. Antonelli , A. Arbet Engels , C. Arcaro , T. T. H. Arnesen , K. Asano , A. Babic´ , C. Bakshi , U. Barres de Almeida , J. A. Barrio , L. Barrios-Jiménez , I. Batkovic´ , J. Baxter , J. Becerra González, W. Bednarek , E. Bernardini , J. Bernete, A. Berti,?, J. Besenrieder , C. Bigongiari , A. Biland , O. Blanch , G. Bonnoli , Ž. Bošnjak , E. Bronzini , I. Burelli , A. Campoy-Ordaz , A. Carosi , R. Carosi , M. Carretero-Castrillo , A. J. Castro-Tirado , D. Cerasole , G. Ceribella , Y. Chai , A. Cifuentes, J. L. Contreras , J. Cortina, S. Covino, , G. D’Amico, P. Da Vela , F. Dazzi , A. De Angelis, B. De Lotto , R. de Menezes , M. Delfino, , J. Delgado, , C. Delgado Mendez , F. Di Pierro , R. Di Tria , L. Di Venere, A. Dinesh, D. Dominis Prester, A. Donini , D. Dorner , M. Doro , L. Eisenberger, D. Elsaesser , J. Escudero , L. Fariña , A. Fattorini , L. Foffano , L. Font , S. Fröse , S. Fukami , Y. Fukazawa, R. J. García López , S. García Soto , M. Garczarczyk , S. Gasparyan, M. Gaug , J. G. Giesbrecht Paiva, N. Giglietto , F. Giordano, P. Gliwny, N. Godinovic´ , T. Gradetzke , R. Grau , D. Green , J. G. Green , P. Günther, D. Hadasch , A. Hahn , T. Hassan , L. Heckmann,, J. Herrera Llorente, D. Hrupec, R. Imazawa, S. Inoue,, D. Israyelyan , J. Jahanvi , I. Jiménez Martínez , J. Jiménez Quiles , J. Jormanainen , S. Kankkunen, T. Kayanoki , J. Konrad , P. M. Kouch , H. Kubo , J. Kushida, M. Láinez , A. Lamastra , E. Lindfors, S. Lombardi , F. Longo,,? , R. López-Coto , M. López-Moya , A. López-Oramas, S. Loporchio, L. Lulic´ , E. Lyard , P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva , M. Manganaro, S. Mangano , K. Mannheim , S. Marchesi , M. Mariotti , M. Martínez , P. Maruševec , A. Mas-Aguilar, D. Mazin,, S. Menchiari , J. Méndez Gallego , S. Menon , D. Miceli,? , J. M. Miranda , R. Mirzoyan , M. Molero González , E. Molina, H. A. Mondal, A. Moralejo , E. Moretti , T. Nakamori, C. Nanci , L. Nava,? , V. Neustroev , L. Nickel, M. Nievas Rosillo , C. Nigro , L. Nikolic´ , K. Nilsson, K. Nishijima , K. Noda, S. Nozaki , A. Okumura , J. Otero-Santos, S. Paiano , D. Paneque , R. Paoletti , J. M. Paredes , M. Peresano , M. Persic,, M. Pihet , G. Pirola , F. Podobnik , P. G. Prada Moroni, E. Prandini, M. Ribó , J. Rico , C. Righi , N. Sahakyan, T. Saito , F. G. Saturni , K. Schmitz , F. Schmuckermaier , A. Sciaccaluga , G. Silvestri, A. Simongini , J. Sitarek, V. Sliusar, D. Sobczynska , A. Stamerra , J. Striškovic´ , D. Strom , M. Strzys , Y. Suda, H. Tajima, M. Takahashi, R. Takeishi , P. Temnikov, K. Terauchi , T. Terzic´ , M. Teshima, , A. Tutone , S. Ubach , J. van Scherpenberg , M. Vazquez Acosta, S. Ventura , G. Verna , I. Viale, A. Vigliano , C. F. Vigorito , E. Visentin, V. Vitale, I. Vovk , R. Walter, F. Wersig , M. Will , T. Yamamoto, and P. K. H. YeungGamma-ray bursts (GRBs) are the most powerful transient objects in the Universe, and they are a primary target for the MAGIC Collaboration. Recognizing the challenges of observing these elusive objects with Imaging Atmospheric Cherenkov Telescopes (IACTs), we implemented a dedicated observational strategy that included an automated procedure for rapid re-pointing to transient sources. Since 2013, this automated procedure has enabled MAGIC to observe GRBs at a rate of approximately ten per year, which led to the successful detection of two GRBs at very high energies (VHE; E > 100 GeV). We present a comprehensive analysis of 42 non-detected GRBs (4 short GRBs) observed by MAGIC from 2013 to 2019. We derived upper limits (ULs) on the observed energy flux as well as on the intrinsic energy flux corrected for absorption by the extragalactic background light (EBL) from the MAGIC observations in selected energy and time intervals. We conducted a comprehensive study of their properties to investigate the reasons for these non-detections, including the possible peculiar properties of TeV-detected GRBs. We find that strong EBL absorption significantly hinders TeV detection for the majority of GRBs in our sample. For a subset of 6 GRBs with redshift z < 2, we compared the UL on the intrinsic flux in the VHE domain with the simultaneous X-ray flux, which is observed to be at the same level in the current population of TeV-detected GRBs. Based on these inferred MAGIC ULs, we conclude that a VHE component with a luminosity comparable to the simultaneously observed X-ray luminosity cannot be ruled out for this sample. © The Authors 2025.We would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the grants PID2019-107988GB-C22, PID2022-136828NB-C41, PID2022-137810NB-C22, PID2022-138172NB-C41, PID2022-138172NB-C42, PID2022-138172NB-C43, PID2022-139117NB-C41, PID2022-139117NB-C42, PID2022-139117NB-C43, PID2022-139117NB-C44, CNS2023-144504 funded by the Spanish MCIN/AEI/ 10.13039/501100011033 and “ERDF A way of making Europe; the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-400/18.12.2020 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also been supported by Centros de Excelencia “Severo Ochoa” y Unidades “María de Maeztu” program of the Spanish MCIN/AEI/ 10.13039/501100011033 (CEX2019-000920-S, CEX2019-000918-M, CEX2021-001131-S) and by the CERCA institution and grants 2021SGR00426 and 2021SGR00773 of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2022-10-4595 and the University of Rijeka Project uniri-prirod-18-48; by the Deutsche Forschungsgemeinschaft (SFB1491) and by the Lamarr-Institute for Machine Learning and Artificial Intelligence; by the Polish Ministry Of Education and Science grant No. 2021/WK/08; and by the Brazilian MCTIC, CNPq and FAPERJ. LN acknowledges funding by the European Union-Next Generation EU, PRIN 2022 RFF M4C21.1 (202298J7KT – PEACE). Authors contributions. A. Berti: MAGIC data analysis, UL calculation, statistics on the triggers and AAS maintenance, paper editing; F. Longo: coordination of the project, discussion on the interpretation, paper editing; D. Miceli: coordination of results, MAGIC data analysis, UL derivation, multi-wavelength interpretation, leading paper drafting, writing and editing; L. Nava: coordination and leading multi-wavelength interpretation, X-ray data analysis, paper editing and drafting. A. Carosi, E. Moretti, K. Noda, A. Donini, A. Fattorini, S. Fukami, J. Green, Y. Suda: MAGIC data analysis; The rest of the authors have contributed in one or several of the following ways: design, construction, maintenance and operation of the instrument(s); preparation and/or evaluation of the observation proposals; data acquisition, processing, calibration and/or reduction; production of analysis tools and/or related Monte Carlo simulations; discussion and approval of the contents of the draft.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000918-M).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).Peer reviewe
