1,720,965 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
TIME-DEPENDENT EFFECTS OF ANTIDEPRESSANT TREATMENTS ON MIRNOME EXPRESSION PROFILE IN HIPPOCAMPUS OF RATS
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Agomelatine Treatment Induces Early and Time- dependent Modulation of Rat Hippocampal MiRNome
No full textTime-dependent effects of antidepressant treatments on miRNome expression profile in hippocampus of rats
No full textIn the last few years it has become clear that in addition to traditional regulatory mechanisms, several novel gene-regulatory systems can produce short-term changes in gene expression and may be potentially involved in the pathophysiology of mood disorders. MicroRNAs (miRNAs), involved in a great number of cellular processes, have emerged as major players in the posttranscriptional regulation of gene expression. Recently, it has been hypothesized that miRNAs could have a role in brain disorders, and emerging evidence suggest that they regulate neuropathology associated processes, such as brain development, dendritic spine morphology and neurite outgrowth. Furthermore, miRNAs appear to be therapeutically relevant effectors of currently used pharmacotherapies including the mood stabilizers lithium and sodium valproate and the SSRI antidepressant (AD) fluoxetine (FLX) (1, 2). Moreover, a recent clinical study reported changes in blood expression of 30 miRNAs after 12 weeks of treatment with the SSRI escitalopram (3). Aim of our study was to analyze the effects of two different ADs, FLX and desipramine (DMI, a tricyclic AD with predominant action on noradrenaline reuptake), on rat hippocampal miRNome expression profile. Moreover, in order to assess the time course of AD effects, treatments were performed for different time lengths: 3, 7 and 14 days. To this aim, total RNA including miRNAs was isolated from each hemi-hippocampus and reverse transcribed. Quantitative Real Time PCR (qRT-PCR) amplification was carried out using TaqMan Array Rodent MicroRNA A+B Card set v3.0 using the δδCt method. A total of about 450 miRNAs were detected in all samples. The analysis of miRNome expression revealed a significant effect of AD treatments at all time points. After 3 days of treatment, FLX down-regulated the expression of 8 miRNAs while DMI up-regulated the expression of 9 miRNAs. A more pronounced effect was found after 7 days of treatment; indeed, at this time point FLX modulated the expression of 35 miRNAs (28 up-regulated and 7 down-regulated) and DMI down-regulated the expression of 13 miRNAs. Interestingly, 8 of them were similarly up-regulated by both drugs, suggesting common targets for FLX and DMI. Finally, after 14 days of treatment FLX modulated the expression of 4 miRNAs (1 up-regulated and 3 down-regulated) and DMI down-regulated the expression of 18 miRNAs. Bioinformatic analysis was performed in order to identify putative target genes of miRNAs significantly modulated by ADs and enriched signalling pathways. The predicted target genes of miRNAs are mainly involved in pathways related to neuronal brain function; moreover, many of them have been previously associated to both depression pathophysiology and to AD mechanism of action. A number of putative miRNA target genes have been selected for validation studies by means of mRNA/protein expression studies. Moreover, in order to better clarify the mechanisms through which ADs can modulate miRNome expression, we have measured the expression of some of the most important components of microRNAs biogenesis pathway, by means of qRT-PCR. The results of this work, showing that AD treatments induce early and time-dependent modifications in hippocampal miRNome expression, could be of help to better understand AD mechanism of action and could represent the starting point for the identification of novel targets for development of new drugs for the treatment of mood disorders
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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