210 research outputs found
The project of the Allianz Headquarters in Trieste. An operative application of a circular approach to the city
No full textNel 1987, viene inaugura la nuova sede di Trieste del Lloyd Adriatico, uno dei principali istituti assicurativi italiani. Posto ai limiti del centro cittadino, il nuovo volume architettonico guarda verso il porto, il grande volano economico che ha reso ricca la città.
Si tratta di un grande complesso, articolato in tre edifici, in stile postmoderno. Un pezzo di città non solo per le dimensioni, ma anche per la razionalità di impianto che riprende gli isolati neoclassici del centro storico di Trieste del XVIII e XIX secolo.
Nel 2013 nasce l'idea di rinnovare l'edificio esistente modificandolo. Questa scelta pone diversi problemi in più rispetto alla possibilità di realizzare un edificio completamente nuovo, più economico e più semplice da realizzare.
La trasformazione di un edificio esistente, però, è un approccio che può consentire una maggiore sostenibilità ambientale in forma integrata, che tiene conto anche di aspetti sociali ed economici. Entra in gioco l'idea di ciclo di vita dell'edificio, dalla costruzione, fino alla sua rigenerazione.
Pensare oggi a una città sostenibile, infatti, significa pensare ad una città orientata a modelli circolari: modelli rigenerativi in cui non ci sono prodotti di scarto e in cui anche il patrimonio edificato viene riutilizzato.
Il caso della sede di Allianz dimostra che, anche negli edifici esistenti, con un'adeguata progettazione, è possibile inserire efficacemente attività con specifiche molto particolari, con impatti positivi sull'occupazione, sull'ambiente e la qualità della vita. Strategico da questo punto di vista è il metodo di progettazione. Ma non solo. Altrettanto importanti sono le condizioni originarie dell’edificio esistente, cioè la sua qualità architettonica e la sua capacità intrinseca di accettare le trasformazioni future
Evaluation of mobile prepaid card's "Zelta Zivtiņa" advertising campaign's "Brīnumi notiek" effectiveness (2011)
No full textSamsonova, L. (2012) Priekšapmaksas kartes „Zelta Zivtiņa” reklāmas kampaņas „Brīnumi notiek” efektivitātes izvērtējums (2011). Bakalaura darbs.
Darbs sastāv no ievada, 3 daļām, autores secinājumiem un priekšlikumiem.
Autore ir Bakalaura studiju programmas, komunikācijas studiju nodaļas 3. kursa studente.
Darba mērķis ir noskaidrot un izvērtēt reklāmas kampaņas „Brīnumi notiek” efektivitāti un izvērtēt tās atgriezenisko saiti, izpētīt, vai papildus aktivitātes reklāmas kampaņas ietvaros, ietekmējušas kampaņas efektivitāti.
Pirmajā daļā ir apkopota izvēlētās pētāmās problēmas teorētiskā bāze un izklāsts. Šajā daļā ir skaidroti jēdzieni reklāma, reklāmas kampaņa, reklāmas kampaņas efektivitāte, pārliecināšana un pircēja ietekmēšana.
Otrajā daļā ir izklāstīta bakalaura darba izstrādē izmantotā metodoloģija. Ir sniegts izvēlēto pētniecības metožu apraksts un pamatojums to izmantošanai bakalaura darba mērķiem un uzdevumiem.
Trešajā darba daļā ir apkopoti un analizēti pētījumā iegūtie rezultāti, uz kuriem balstoties, tiek izvērtēta reklāmas kampaņas efektivitāte.
Pētījuma rezultāti uzrāda, ka reklāmas kampaņa „Brīnumi notiek” vērtējama vien kā daļēji efektīva, jo neraugoties un papildus izmantotajiem reklāmas aktivitāšu elementiem, drīz vien tikusi aizmirsta, dzirdot kampaņas nosaukumu ir grūtības atcerēties, kas tās ietvaros tika piedāvāts, kā arī papildus, netradicionālās reklāmas aktivitātes sniedz rezultātu īslaicīgā periodā un iedarbojas momentāni.
Atslēgas vārdi: Zelta Zivtiņa, reklāmas kampaņa, efektivitāte, pārliecināšanaSamsonova L. (2012) Evaluation of mobile prepaid card's ''Zelta Zivtiņa'' advertising campaign's "Brīnumi notiek" effectiveness (2011) Bachelor thesis.
The work consists of an introduction, 3 parts and author’s conclusions and prepositions.
The author of this work is a 3rdyear student of Bachelor’s study program, curriculum of communication.
The aim of this work is to clarify and evaluate the effectiveness of advertising campaign ‘’Brīnumi notiek’’, assess the feedback and research whether the additional activities that have been done within the advertising campaign have affected the effectiveness of the campaign.
First part includes the theoretical basis and recital of the chosen research proposition. In this part expressions advertising, advertising campaign, the effectiveness of advertising campaign, persuasion and the influence of the customer are explained.
The second part of the work outlines the methodology used in the development of the bachelor work. There is given the description of the chosen research methods and the substantiation for its utilization.
The third part summarizes and analyzes the results collected in the research, and the effectiveness of the advertising campaign is being evaluated based on it.
The results indicate that the advertising campaign ‘’Brīnumi notiek’’ is only partly effective because in spite of the advertising activities they have done, it was soon forgotten. It is hard to recall the name of the campaign, the purpose of it and the additional, bizarre advertising activities that had been done works only for a short moment.
Key words: Zelta Zivtiņa, advertising campaign, effectiveness, persuasio
The activity approach to building research competencies among prospective teachers
Get PDFThis article considers the activity approach to building research competencies among prospective teachers of foreign languages.The author analyzes the opportunities of using the methodology of station training, teaching by doing, learning through training, research method in training prospective teachers of foreign languages. The author thinks that the use of these methods should promote the formation of research competencies of prospective teachers of foreign languages. © 2014 Taylor & Francis Group
The activity approach to building research competencies among prospective teachers
No full textThis article considers the activity approach to building research competencies among prospective teachers of foreign languages.The author analyzes the opportunities of using the methodology of station training, teaching by doing, learning through training, research method in training prospective teachers of foreign languages. The author thinks that the use of these methods should promote the formation of research competencies of prospective teachers of foreign languages. © 2014 Taylor & Francis Group
Lung pathology of covid-19 in Moscow
No full textWe analyzed lung material from 22 dead obtained on autopsy for the period from March, 6 to April,30, 2020, in various clin-ics in Moscow. For this period died 532 patients (219 female, 324 male),with mean age 67.47±14.67 years. In all 22 deceased patients, the diagnosis of COVID-19 was confirmed in vivo (PCR study on material from the nasopharynx, in some patients by a positive PCR analysis in material obtained from trachea and lung tissue during autopsy). The average age of these deceased was 72.27±10.74 years, the duration of the disease ranged from 5 to 32 days. In severe COVID-19, patients develop viral interstitial pneumonia with the development of diffuse alveolar damage, which causes a severe course of the disease, hypoxia, and respiratory failure. An incomplete correspondence was found between morphological changes in the lungs (phases of diffuse alveolar damage) and the duration of the disease, which is most likely due to the unspecified duration of the asymptomatic course in many patients. The course of a new coronavirus infection is characterized by primary damage to the lungs, an increase in hemoglobin concentration in the blood, a decrease in SpO , lymphopenia with a simultaneous increase in leukocytosis, and signs of hyperco-agulation in extremely severe patients. Virus-bacterial pneumonia may occur mainly in individuals with tracheal intubation, with tracheostomy and prolonged mechanical ventilation on any stage of the disease.
Presentations in English in Academic Environment
No full textBakalaura darba tēma ir prezentācijas angļu valodā akadēmiskā vidē. Bakalaura darba mērķis ir pierādīt, ka akadēmiskās prezentācijas angļu valodas kursā ir ļoti svarīgas un noderīgas studentiem, jo tās palīdz apgūt angļu valodu un paplašināt tas pielietojumu. Darba teorētiskajā daļā ir aprakstīta saikne starp akadēmiskajām prezentācijām un valodas pielietošanu. Darbā tiek pētīta akadēmisko prezentāciju plānošana un sagatavošana, struktūra, vizuālo materiālu nozīme, kā arī akadēmisko prezentāciju pasniegšana auditorijai. Darba praktiskā daļa ir uz anketām un to analīzes balstīts pētījums. Šī daļa satur arī uz vērojumu balstītu pētījumu. Pētījums pierāda, ka akadēmisko prezentāciju pareiza organizēšana un pasniegšana ir lieliska iespēja studentiem iemācīties lietot angļu valodu dažādās dzīves sfērās.The theme of the bachelor paper is presentations in English in academic environment. The goal of the bachelor paper is to show that academic presentations during the EFL course are very important and useful for students in order to develop their abilities to use the English language. The theoretical part describes the connection between academic presentations and the use of the English language. It explores the preparation and planning of academic presentations, the structure, the importance of visual aids and the instructions on giving them. In the practical part the author analyses questionnaires. It also contains the analysis of observations. The research confirmed that academic presentations, if properly organized and delivered, are a great chance for students to learn to use the English language in different life spheres
Support vector regression applied to the determination of the developmental age of a <i>Drosophila</i> embryo from its segmentation gene expression patterns
No full textAbstract
Motivation: In this paper we address the problem of the determination of developmental age of an embryo from its segmentation gene expression patterns in Drosophila.
Results: By applying support vector regression we have developed a fast method for automated staging of an embryo on the basis of its gene expression pattern. Support vector regression is a statistical method for creating regression functions of arbitrary type from a set of training data. The training set is composed of embryos for which the precise developmental age was determined by measuring the degree of membrane invagination. Testing the quality of regression on the training set showed good prediction accuracy. The optimal regression function was then used for the prediction of the gene expression based age of embryos in which the precise age has not been measured by membrane morphology. Moreover, we show that the same accuracy of prediction can be achieved when the dimensionality of the feature vector was reduced by applying factor analysis. The data reduction allowed us to avoid over-fitting and to increase the efficiency of the algorithm.
Availability: This software may be obtained from the authors.
Contact: [email protected]
Keywords: gene expression patterns; development; embryo staging; support vector regression; segmentation genes; Drosophila.
*To whom correspondence should be addressed.</jats:p
Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury
Get PDFHryshchuk L. A., Besky V. O., Marushchak M. I. Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury. Journal of Health Sciences. 2014;4(14):175-181. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A175-181
https://pbn.nauka.gov.pl/works/512853
DOI: 10.5281/zenodo.13349
http://dx.doi.org/10.5281/zenodo.13349
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1107. (17.12.2013).
© The Author (s) 2014;
This article is published with open access at Licensee Open Journal Systems of Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
Conflict of interest: None declared. Received: 15.11.2014. Revised 05.12.2014. Accepted: 10.12.2014.
Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень
Dynamics of pulmonary damage parameters in experimental
HCl-induced acute lung injury
Грищук Л.А., Беський В.О., Марущак М.І.
Hryshchuk L.A., Besky V.O., Marushchak M.I.
ДВНЗ «Тернопільський державний медичний університет імені
І.Я. Горбачевського МОЗ України»
SHEI Ternopil State Medical University named after I.Ya. Gorbachevsky MOH of Ukraine
Резюме. Метою даного дослідження було визначити ступінь розвитку набряку легень і рівень метаболізму сурфактанта у динаміці гострого ураження легень хлоридною кислотою. Досліди були проведені на 60 білих статевозрілих нелінійних щурах-самцях масою 200-220 г, яким моделювали гостре ураження легень шляхом інтратрахеального введення хлоридної кислоти при рН 1,2 в дозі 1,0 мл/кг на вдиху. Визначали індекс оксигенації рO2/FiO2 артеріальної крові, вміст білка у бронхоальвеолярному змиві, Wet/Dry індекси і коефіцієнт стабільності міхурців піни за R. Pattle.
Розвиток легеневого ушкодження за умови інтратрахеального введення хлоридної кислоти підтверджено як підвищенням втричі концентрації білка у БАЗ до кінця першої доби, так і розрахованими індексами розвитку легеневого набряку, які вказували на достовірне зростання набряку легеневої тканини і легеневого ексудату протягом часу спостереження. Встановлено прогресуюче зниження рівня показників поверхневої активності ССЛ протягом першої доби спостереження, що характеризується значним збільшенням рівня максимального поверхневого натягу з одночасним зниженням індексу стабільності на 45,8 % порівняно з контролем.
Отже, отримані дані чітко вказують на формування ГУЛ за рахунок розвитку набряку легеневої тканини та накопичення ексудативної рідини, і як наслідок, порушення оксигенації з розвитком гіпоксемії. Акумуляція рідини, багатої білками в альвеолах є чинником інактивації сурфактанту, що зумовлює зниженням індексу стабільності.
Ключові слова: гостре ураження легень, хлоридна кислота, набряк легень, сурфактантна система.
Summary. The aim of this study was to determine the degree of pulmonary edema and metabolic rate of surfactant in the dynamics of hydrochloric acid (HCl)-induced acute lung injury (ALI).
The development of lung damage in case of intratracheal introduction of HCl confirmed as three times higher concentration of protein in bronchoalveolar lavage after 24 hours of experiment, and rise calculated indices of pulmonary edema, which indicated a significant increase in lung tissue edema and pulmonary fluid in all groups of observation. It was found a progressive decrease in surface activity indicators of pulmonary surfactant system during the first day of observation: significant increase in the level of maximum surface tension with a simultaneous decrease in the stability index by 45.8%. Thus, the data indicate the formation of ALI by edema of the lung tissue and accumulation of exudative fluid, and as a consequence, impaired oxygenation with the development of hypoxemia. Accumulation of rich in proteins fluid in the alveoli is the factor of surfactant inactivation that leads to decreased of stability coefficient.
Key words: acute lung injury, hydrochloric acid, pulmonary edema, surfactant system.Hryshchuk L. A., Besky V. O., Marushchak M. I. Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury. Journal of Health Sciences. 2014;4(14):175-181. ISSN 1429-9623 / 2300-665X.
http://journal.rsw.edu.pl/index.php/JHS/article/view/2014%3B4%2814%29%3A175-181
https://pbn.nauka.gov.pl/works/512853
DOI: 10.5281/zenodo.13349
http://dx.doi.org/10.5281/zenodo.1334
Pathomorphological and immunohistochemical features of lymph nodes in COVID-19 patients (Autopsy study)
No full textIntroduction. The pathogenesis of the novel coronavirus infection COVID-19 is being actively studied. Nevertheless, our up-to-date knowledge of lymphoid tissue response in the secondary immune organs during severe COVID-19 remains extremely limited. The aim of the study was to evaluate patterns of immu-nomorphological alterations in lymph nodes in patients with severe COVID-19 and to assess lymphocytes functional activity in them. Materials and methods. Lymph node tissue (autopsy material) from 17 deceased patients with severe COVID-19 was examined by histological and immunohistochemical methods using antibodies to CD4, CD8, CD20, CD30, CD123, CD138, PD-1. Results. Examined lymph nodes demonstrated lymphoid follicles reduction and paracortex expansion with reactive plasmacytosis and extrafollicular B-cell activation as well as sinus histiocytosis, variable hemophago-cytic cells, and blood vessel congestion. Red thrombi were observed in some lymph nodes. Hemorrhages in the stroma were frequent, and massive hemorrhages were found in individual nodes. Immunohistochemical study revealed CD4 T-helpers predominance in the paracortex andcytotoxic CD8 lymphocytes depletion together with an increase in the expression of both the PD-1 suppressor protein and the CD30 activation anti-gen on the lymphocyte surface. CD123-positive plasmacytoid dendritic cells resided in sinuses in abundance. Conclusion. Demonstrated B-associated zone reduction and cytotoxic T-lymphocytes depletion with an up-regulation of PD-1 expression in the lymph nodes in patients with severe COVID-19 indicate immune response exhaustion. At the same time, observed significant reactive plasmacytosis with the presence of numerous T-helper cells constitutes a morphological substrate of the humoral immunity. These findings might indicate the ineffec-tiveness of the humoral response at late stages of COVID-19 infection in context of cytotoxic immunity failure. +
Determination of the Developmental Age of a Drosophila Embryo from Confocal Images of its Segmentation Gene Expression Patterns
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