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Effect of changes of alveolar and mean transmural pressure on the resistance of the pulmonary circulation in the rat
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Fatal asthma in a young patient with severe bronchial hyperresponsiveness but stable peak flow records.
No full textWe report the sudden death of a 16 yr old boy with asthma. At presentation, the patient had symptoms of active asthma, mild bronchoconstriction, severe airway hyperresponsiveness to methacholine, and increased variability of peak expiratory flow records. After the patient was placed on inhaled beclomethasone (1 mg b.i.d preceded by inhaled fenoterol 0.4 mg b.i.d) he rapidly felt better, lung function improved, but airway responsiveness remained severe. Four months later, on the day he died, he was well until a fatal attack of asthma occurred around midnight without identifiable precipitating factors. Taken to hospital, he was dead on arrival. Necroscopy and microscopy showed the characteristic features of asthma death. This case report suggests that; a) asthma death may occur suddenly and unexpectedly; b) asthma death may not be prevented by long-term treatment with high-dose inhaled beclomethasone; c) severe bronchial hyperresponsiveness, even in the presence of stable peak flow records, may identify asthmatic patients at risk of sudden death
Late asthmatic reactions, airway inflammation and chronic asthma in toluene-diisocyanate-sensitized subjects.
No full textTo determine the importance of airway inflammation for exacerbation and prognosis of asthma induced by toluene diisocyanate (TDI), we first examined sensitized subjects during asthmatic reactions induced by exposure to TDI in the laboratory. We observed that late and dual, but not early, asthmatic reactions induced by TDI are accompanied by a transient increase of airway responsiveness, bronchoalveolar neutrophilia followed by eosinophilia and by an increase of LTB4 and albumin in bronchoalveolar lavage fluid. All these effects were prevented by pretreatment with prednisone. In addition, we examined the lung pathology of 1 sensitized subject who died after exposure at work. The pathologic features of fatal asthma induced by TDI and of chronic asthma induced by TDI suggest the importance of inflammation for the exacerbation and prognosis of the disease
Effect of lung volume and mean transmural pressure on the resistance of pulmonary circulation in the rat.
No full textRhinovirus-induced interferon production in asthma
No full textAfter reading the article by Sykes et al, we would like to comment on impaired response to rhinovirus in relation to asthma severity
Effect of changes of alveolar and mean transmural pressures on the resistance of pulmonary circulation in the rat.
No full textLa genetica dell’asma bronchiale.
No full textL’asma bronchiale è una malattia infiammatoria cronica delle vie aeree caratterizzata da ricorrenti episodi di ostruzione reversibile del flusso aereo responsabili delle crisi di respiro sibilante, senso di costrizione toracica, dispnea e tosse stizzosa1. L’atopia, definita come un aumento della sintesi di immunoglobuline E (IgE) in risposta all’esposizione a comuni allergeni, è uno dei il fattore di rischio più importanti per la comparsa di asma 2. Da un punto di vista genetico, l’asma bronchiale è una malattia genetica complessa dovuta all’interazione tra fattori genetici, che conferiscono soprattutto la predisposizione alla comparsa dell’asma, e fattori ambientali, quali allergeni, inquinanti atmosferici ed infezioni che agiscono soprattutto come fattori scatenanti la malattia.In questo capitolo dopo una breve introduzione allo studio delle malattie genetiche complesse, passeremo in rassegna gli studi ed i progressi compiuti nell’identificare i geni potenzialmente coinvolti nella patogenesi dell’asma
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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