930 research outputs found
Data for: Physical and Emotional Support of the Neighborhood for Older Adults: A Comparison of the United States and Germany
No full textThe living environment plays a critical role in healthy aging. As older adults’ physical abilities decrease, they are less likely to compensate for physical barriers and their action radius decreases. Therefore, older adults strongly depend on the neighborhood to meet their needs. In addition to coping with the physical environment, older adults’ fulfillment of emotional needs plays a key role in supporting successful aging in place. Further, historical differences in the built environment in the United States vs. Europe may lead to different expectations of need-fulfillment in different countries. The aim of this study was to shed light on older adults’ (N = 577, ages 70+) living situations and their demands on the neighborhood in two countries, the United States (n = 350) and Germany (n = 227). Differences between countries were more pronounced than differences between age groups or living areas, indicating that cultural influence is a key aspect of needs assessment for neighborhood design. In line with the literature in environmental gerontology, participants’ needs spanned across various dimensions related to the physical, social and psychological environment, which we categorized into global, local, and social needs. As opposed to Americans, Germans had higher expectations of their immediate neighborhood to fulfill their local (e.g., public transportation) and social needs (e.g., family nearby), but countries did not differ regarding global needs such as safety. Our findings suggest that successful aging in place can be supported by a neighborhood that meets people’s needs, but also takes their cultural background into consideration
Abdominal space-occupying lesion. Bilateral pheochromocytoma in MEN IIa and well differentiated retroperitoneal liposarcoma
No full textRecueil d'œuvres en prose et en vers, probablement toutes dues à Naṣīr al-Dīn Muḥ. b. Ibrāhīm b. ʿAbd-ullāh al-Rammāl al-Muʿazzim al-Sāʿatī al-Haykalī (cf. f. 32, 51, 79v et 80), dont le taẖalluṣ est (f. 129v, etc.) Naṣīrī ou Naṣīr. Il vécut à la Cour du seldjoucide Ġīyās̱ al-Dīn Kay H̱usraw III (qui régna depuis 663H./1264-5) à Aqsarā (Aksaray) et Qayṣariya (Kayseri) (cf. f. 51 et 153) ; il fait allusion à 7 livres (kitāb) qu'il a composés au f. 4.
No full textContient : DAQĀʾIQ al-ḤAQĀʾIQ ; KITĀB-i MŪʾNIS al-ʿAVĀRIFNumérisation effectuée à partir d'un document original.Le manuscrit, très endommagé, est acéphale et incomplet de la fin. Restauré assez arbitrairement, il comporte de fort nombreuses lacunes et inversions de feuillets. L'ordre dont nous Proposons la restitution demeure souvent conjectural.Au f. 1, un ex-libris, qui paraît être celui de C. Raue de Berlin, a été gratté. On lit aussi « 147 pag. » de la main de C. Raue (comp. aux ms. Persan 13, Persan 38, etc.), ainsi qu'une notice « Histoire d'un Roy de Perse », d'une autre main non identifiée. Le ms. provient de la bibliothèque de M. Thévenot (n° 175). Au f. 1 figure une notice signée d'Armain (n° 368)
Detection of an unidentified TeV gamma-ray source HEE J1303-631 close to the galactic plane with the H.E.S.S. Chrenkov telescopes
No full textA new TeV gamma-ray source named HESS J1303-631 has been serendipitously discovered in the field of view of the H.E.S.S. Cherenkov telescopes pointed towards the binary system PSR B1259-63/SS 2883. The data were taken between February and June 2004. Up to now, no counterpart at other wavelengths was found. HESS J1303-631 is extended and emits on a constant flux level. The detection and basic features of this new source are reported as well as results from follow-up observations in 2005
Lungenwurminfektionen der Katze – Ergebnisse koproskopischer und serologischer Diagnostik sowie der Bildgebung im Verlauf der experimentellen Infektion
No full textDo all roads lead to rome? The potential of different approaches to diagnose Aelurostrongylus abstrusus infection in cats
No full textAn infection with the cat lungworm, Aelurostrongylus abstrusus, can be subclinical, but it can also cause severe respiratory clinical signs. Larvae excretion, antibody levels, clinical assessment findings of the respiratory system and diagnostic imaging findings were recorded and compared for six cats with experimental aelurostrongylosis. In five cats, patency started 33–47 days post infection (pi), but two cats excreted larvae only in long intervals and low numbers. Positive ELISA results were observed in four cats with patent aelurostrongylosis, starting between five days before and 85 days after onset of patency. One seropositive cat remained copromicroscopically negative. Mild respiratory signs were observed in all cats examined. A computed tomographic (CT) examination of the lungs displayed distinct alterations, even in absence of evident clinical signs or when larvae excretion was low or negative. The thoracic radiograph evaluation correlated with the CT results, but CT was more distinctive. After anthelmintic treatment in the 25th week post infection, pulmonary imaging findings improved back to normal within 6–24 weeks. This study shows that a multifaceted approach, including diagnostic imaging, can provide a clearer diagnosis and monitoring of disease progression. Furthermore, a CT examination provides an alternative to post mortem examination and worm counts in anthelmintic efficacy studies
Comparison of approaches for parameter identifiability analysis of biological systems
No full textModeling of dynamical systems using ordinary differential equations is a popular approach in the field of Systems Biology. The amount of experimental data that are used to build and calibrate these models is often limited. In this setting, the model parameters may not be uniquely determinable. Structural or a priori identifiability is a property of the system equations that indicates whether, in principle, the unknown model parameters can be determined from the available data
Efficacy of Bravecto® Plus spot-on solution for cats (280 mg/ml fluralaner and 14 mg/ml moxidectin) in the prevention of feline Aelurostrongylus abstrusus infection evaluated in a multi-diagnostic approach
No full textBackground Aelurostrongylus abstrusus is one of the most important respiratory nematodes of felines. Infections may lead to respiratory clinical signs with varying severity or even death, emphasizing the need for preventive treatment of cats with outdoor access to circumvent patent infections. Methods Therefore, the preventive efficacy of a spot-on formulation of 280 mg/ml fluralaner and 14 mg/ml moxidectin (Bravecto (R) Plus spot-on solution for cats, MSD) against A. abstrusus was evaluated in a negative controlled, randomized and partially blinded efficacy study with 28 purpose-bred cats in a non-terminal design. In three different treatment regimes, the minimum recommended dose of 40 mg fluralaner and 2.0 mg moxidectin/kg bodyweight (BW) was administered once at 12, 8 or 4 weeks (study group G1, G2 and G3, respectively) prior to experimental infection with 300 third-stage A. abstrusus larvae, while G4 served as placebo-treated control. Results From 30 to 46 days post infection (dpi; SD 114 to 130), faeces were sampled to monitor first-stage larvae (L1) excretion for efficacy determination. Secondary efficacy criteria, including respiratory parameters, serological antibody levels and computed tomography (CT) findings, were assessed once before enrolment (SD -7 to -1) and before infection (SD 75 to 83). After infection, CT evaluation was performed once at 47-50 dpi (SD 131 to 134), and respiratory parameters and antibody levels were regularly assessed twice or once a week, respectively (1 up to 78 dpi, SD 85 up to 162). All animals in the control group excreted L1 by 33-37 dpi and remained positive throughout the study period from 41 to 46 dpi (SD 125 to 130). In the treatment groups, only one animal each of G1 and G2 excreted L1 at two consecutive days, and four cats of G1, two of G2 and three of G3 were positive on single occasions. While the geometric mean (GM) of the maximum number of excreted L1 per 5 g of faeces was 7380.89 in the control group (G4), GMs were significantly lower in the treatment groups with 1.63 in G1, 1.37 in G2 and 0.79 in G3. Thus, based on GMs, the reduction in excreted L1 exceeded 99.9% in all three treatment groups. Based on CT severity scores, all lungs of the animals of the control group showed severe pulmonary changes post infection, whereas lungs of the cats of the treatment groups were either unaltered (4 animals), mildly (11 animals), or moderately altered (5 animals). Moreover, seroconversion was observed in all cats of the control group, but not in those of the treatment groups. Conclusions The combination of diagnostic methods used in this non-terminal study yielded coherent and reliable results. A single administration of Bravecto (R) Plus spot-on solution for cats was well tolerated and effective in the prevention of aelurostrongylosis for at least 12 weeks
Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide
No full textPoly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed
Hydrogels with incorporated graphene oxide as light‐addressable actuator materials for cell culture environments in lab‐on‐chip systems
No full textGraphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium. (C) 2016 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimThis research project was funded by the German Federal Ministry of Education and Research (BMBF) within the research frame of "NanoMatFutur": 13N12585
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