1,720,982 research outputs found
Lack of correlation between the immunologic response and the morphometry of the lymphocytic clusters formed in microtray wells.
No full textLack of correlation between the immunologic response and the morphometry of the lymphocytic clusters formed in microtray wells
Indagini sulla espressione della glutatione S-transferasi di tipo placentare in epatociti di Ratto neonato iniziati o meno in epoca prenatale con dimetil nitrosamina.
No full textIndagini sulla espressione della glutatione S-transferasi di tipo placentare in epatociti di Ratto neonato iniziati o meno in epoca prenatale con dimetil nitrosamina
Lead ammonium citrate acetate (LACA) prevents spontaneous apoptosis of primary adult rat hepatocytes in synthetic medium
No full textLead ammonium citrate acetate (LACA) prevents spontaneous apoptosis of primary adult rat hepatocytes in synthetic mediu
L’iniziazione prenatale con dimetilnitrosamina modifica l’espressione (onco)genetica degli epatociti postnatali in vivo ed in coltura primaria in vitro.
No full textL’iniziazione prenatale con dimetilnitrosamina modifica l’espressione (onco)genetica degli epatociti postnatali in vivo ed in coltura primaria in vitro
GST-P expression and in vitro promotion of neonatal rat hepatocytes initiated in utero with DMN
No full textGST-P expression and in vitro promotion of neonatal rat hepatocytes initiated in utero with DM
A novel approach to extend the survival of skin xenografts without entailing general immunosuppression or systemic toxicity
No full textThe feasibility of using antigenically disguised skin xenotransplants to cover extensive burns for a suitable time lag without administering immunosuppressive drugs was tested experimentally. Pieces of human skin that had been preincubated for 3 h at 37 degrees C with either mouse anti-human beta 2-microglobulin monoclonal antibody (beta 2m-McAb) or PBS (controls) were grafted onto the backs of immunologically competent Swiss mice, and the time required for their rejection or substitution by normal autogenous skin was determined. Thus, it was found that the beta 2m-McAb-pretreated xenografts had a significantly longer mean survival time than the control grafts. An even longer skin xenograft MST was obtained when beta 2m-McAb was repeatedly injected, at weekly intervals, just beneath the transplants. Parallel immunohistochemical studies showed that the beta 2m-McAb entered the grafts and was bound to its targets both in epidermis and dermis. Moreover, a small amount of beta 2m-McAb administered at the outset significantly hindered the reactive proliferation of primed mouse spleen cells cultured in the presence of human epidermal cells. Finally, neither toxic effects nor a weakening of immune competence were elicited by repeated intraperitoneal injections of beta 2m-McAb. Therefore, it seems expedient to propose the use of beta 2m-McAb to delay the rejection of skin xenografts as this antibody harmlessly prevents, wholly or in part, the activation of the recipients' lymphocytes. This would positively aid any patient urgently needing xenograft cover of extensive burns
Lead ammonium citrate acetate (LACA) prevents spontaneous apoptosis in primary adult rat hepatocytes in synthetic medium.
No full textLead ammonium citrate acetate (LACA) prevents spontaneous apoptosis in primary adult rat hepatocytes in synthetic medium
A novel strategy for the elongation of the survival of skin xenografts without concurrent general immunosuppression.
No full textA novel strategy is reported for the elongation of the survival of skin xenografts without concurrent general immunosuppression
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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