104 research outputs found
Adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer
No full textBernadette Biondi, Melania Pulcrano, Loredana Pagano, Gaetano LombardiDepartment of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, ItalyAbstract: Various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulating hormone (rhTSH) for radioiodine remnant ablation. On this basis, rhTSH was approved in Europe for the radioiodine ablation of low-risk differentiated thyroid cancer (DTC) during thyroid hormone therapy with L-thyroxine (L-T4). Moreover, in December 2007, the US Federal Drug Administration approved the use of rhTSH for adjuvant treatment with radioiodine in patients with DTC without evidence of metastatic thyroid cancer. Quality of life was found to be better with rhTSH preparation than with L-thyroxine withdrawal, thereby resulting in benefits for society as a whole. Furthermore, rhTSH for radioiodine remnant ablation results in a longer effective radioiodine half-life within remnant thyroid tissue and a lower specific absorbed dose in the blood and exposure of bone marrow to X-rays. More studies are required to establish the amount of radioiodine to be administered especially in high-risk patients. Keywords: thyroid cancer, thyrotropin, radioiodine (131I) remnant ablation (RRA), quality of life, ray exposur
POORLY DIFFERENTIATED FOLLICULAR THYROID CARCINOMA: PROGNOSTIC FACTORS AND RELEVANCE OF HISTOLOGICAL CLASSIFICATION
No full textBackground. Poorly differentiated follicular carcinomas (PDFC) of the thyroid represent an heterogeneous but distinct group of tumors, clinically and histopathogenetically intermediate between follicular-derived well-differentiated and anaplastic carcinomas. The existence of this group of tumors was first proposed independently by Sakamoto et al. in 1983 and Carcangiu et al. in 1984 according to substantially different diagnostic criteria. Indeed, although the number of articles written on the subject of PD carcinoma has grown exponentially during the last decade, at the present the diagnostic criteria differ between various authors. Moreover, there is no clear definition of the histological, immunohistochemical and genetic characteristics of PDFC. Furthermore, although the majority of studies show the aggressiveness of PDFC with a high propensity for local recurrence and distant metastasis, there is no consensus regarding the prognostic indicators for these tumors.
Objective: The work performed during my Doctorate thesis in France contributes to clarify the histological definition and to identify clinical, histological, immunohistochemical characteristics of PDFC. For this purpose, parallel clinical, histological and immunohistochemical investigations have been performed.
Methods: Forty patients affected by PDFC were identified on the basis of a trabecular, insular, or solid (TIS) growth pattern, and their clinical outcome was correlated with histological architecture, cytological characteristics and expression of various markers of cell proliferation and differentiation such as cyclin A, B1, D1 and E, Ki67, TPO, galectin 3, Duox, VEGF, EGFR, P53.
Results: The mean survival was 5.2 5 years. At 5 years,the survival rate was 63% and the metastasis-free survival rate was 57%. An older age at the time of diagnosis and a larger tumor size were associated with an increased risk of distant metastases and of cancer related death whereas a high expression of Duox was associated with a reduced risk of death. In these patients with PDFC, no histological features or marker expression was prognostic. Conclusion: this study confirmed that PDFC has a more aggressive behavior than well differentiated carcinoma (WDC); prognosis is related to indicators that are relevant in patients with WDC, advanced age and larger tumor size
Identificazione di proteine che legano “in vitro” la 3’UTR di RNA messaggeri per l’istone H3.3
No full textEsiste una correlazione tra il valore del rapporto K/R nelle protammine e la loro modalità di legame al DNA?
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