188 research outputs found
The effect of fasting and the dietary levels of vitamins on the concentration of free amino acids in the plasma and tissues of chicks
No full text68 leaves ill.Printing process for original document: Multilith proces
Milvexian for the Prevention of Venous Thromboembolism
No full textBackground: Factor XIa inhibitors for the prevention and treatment of venous and arterial thromboembolism may be more effective and result in less bleeding than conventional anticoagulants. Additional data are needed regarding the efficacy and safety of milvexian, an oral factor XIa inhibitor. Methods: In this parallel-group, phase 2 trial, we randomly assigned 1242 patients undergoing knee arthroplasty to receive one of seven postoperative regimens of milvexian (25 mg, 50 mg, 100 mg, or 200 mg twice daily or 25 mg, 50 mg, or 200 mg once daily) or enoxaparin (40 mg once daily). The primary efficacy outcome was venous thromboembolism (which was a composite of asymptomatic deep-vein thrombosis, confirmed symptomatic venous thromboembolism, or death from any cause). The principal safety outcome was bleeding. Results: Among the patients receiving milvexian twice daily, venous thromboembolism developed in 27 of 129 (21%) taking 25 mg, in 14 of 124 (11%) taking 50 mg, in 12 of 134 (9%) taking 100 mg, and in 10 of 131 (8%) taking 200 mg. Among those receiving milvexian once daily, venous thromboembolism developed in 7 of 28 (25%) taking 25 mg, in 30 of 127 (24%) taking 50 mg, and in 8 of 123 (7%) taking 200 mg, as compared with 54 of 252 patients (21%) taking enoxaparin. The dose-response relationship with twice-daily milvexian was significant (one-sided P<0.001), and the 12% incidence of venous thromboembolism with twice-daily milvexian was significantly lower than the prespecified benchmark of 30% (one-sided P<0.001). Bleeding of any severity occurred in 38 of 923 patients (4%) taking milvexian and in 12 of 296 patients (4%) taking enoxaparin; major or clinically relevant nonmajor bleeding occurred in 1% and 2%, respectively; and serious adverse events were reported in 2% and 4%, respectively. Conclusions: Postoperative factor XIa inhibition with oral milvexian in patients undergoing knee arthroplasty was effective for the prevention of venous thromboembolism and was associated with a low risk of bleeding. (Funded by Bristol Myers Squibb and Janssen Research and Development; AXIOMATIC-TKR ClinicalTrials.gov number, NCT03891524.)
Estimated Soft X-ray Spectrum And Ionization Of Molecular Hydrogen In The Central Molecular Zone Of The Galactic Center
No full textFrom observed high H column densities in the Central Molecular
Zone (CMZ), a region with a radius of 150~pc at the center of
our Milky Way Galaxy, H ionization rates of
~~3~~10~s have been
reported.\footnote{Oka, T., Geballe, T. R., Goto, M., Usuda, T., and
McCall, B. J. 2005, ApJ, \textbf{632} 882}\footnote{Geballe, T. R.,
and Oka, T. 2010, ApJ, \textbf{709} L70.} This ionization rate which
is higher than those in dense clouds and diffuse clouds in the
Galactic disk by 100 and 10, respectively, have been
ascribed to high flux of cosmic rays due to the high density of
supernova remnants in the region. We are studying the ionization
rate due to X-rays intensely observed in the CMZ as a possible
competing process. Last year we reported the estimated ionization
rate due to observable X-rays with energy 1 - 10 keV as negligible
compared to the observed .
\vspace{0.1 in}
However, just like cosmic ray ionization is dominated by low
energy (~100~MeV) cosmic rays that are not directly
observable because of deflection by solar magnetic field, the X-ray
ionization is dominated by soft X-rays (~1~keV) that are not
observable due to optical depth of the foreground gas. Our task
therefore resembles those by Hayakawa et al.
(1961)\footnote{Hayakawa,S.,Nishimura, S., Takayanagi, K. 1961,
PASJ, \textbf{18} 184} and Spitzer and Tomasko
(1968)\footnote{Spitzer,L. T., Tomasko, M. G. 1968, ApJ,
\textbf{152} 971} who estimated the cosmic ray ionization rate
based on high energy (~1 GeV) cosmic ray observations.
\vspace{0.1 in}
We use theoretical X-ray spectrum and interpolate the observed X-rays at 4 keV, which are observable nearly un-attenuated from the CMZ, to the low energy region. Two theoretical spectra are presented, one due to Bremsstrahlung with variable temperature and proper cut off and the
other the advection-dominated accretion flow (ADAF)
model.\footnote{Yuan, F., Quataert, E., Narayan, R. 2003, JPJ,
\textbf{598} 301.}. Discussion of the calculations and the results
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Previous issue date: 2014-06-1
beta-decay half-lives and beta-delayed neutron multiplicities of the neutron drip-line nuclei B-19, C-22, and N-23
No full textBeta-decay properties of the neutron drip-line nuclei B-19, C-22, and N-23 have been studied using projectile fragments from 95 MeV/nucleon Ar-40 ions incident on a Ta-nat target. The beta-decay half-lives of C-22 and N-23 have been determined for the first time to be 6.1(-1.2)(+1.4) and 14.1(-1.5)(+1.2) ms, respectively. The half-life of B-19 was reinvestigated, resulting in a new value of 2.92+/-0.13 ms. The beta-delayed neutron multiplicities have also been determined to be P-1n=71.8(-9.1)(+8.3)%, P-2n=16.0(-4.8)(+5.6)% for B-19, P-1n=61(-13)(+14)% for C-22, and P-1n=42.2(-6.5)(+6.3)%, P-2n=8.0(-3.4)(+3.8)% for N-23. The results are compared with theoretical predictions
IONIZATION OF H BY X-RAYS IN THE CENTRAL MOLECULAR ZONE OF THE GALACTIC CENTER
No full textAuthor Institution: Department of Astronomy and Astrophysics and Department of Chemistry, the Enrico Fermi Institute, the University of Chicago, Chicago, Illinois, 60637, USARecent studies of the Galactic center using the infrared spectrum of H have revealed a high ionization rate of H on the order of ~~310~s in wide regions of the Central Molecular Zone (CMZ), a region with a radius of ~150~pc at the Galactic center. 882} L70.} So far we have ascribed this ionization rate, which is an order of magnitude higher than in the Galactic disk, to cosmic rays because of a high density of supernova remnants in the CMZ. In view of the abundant intense X-ray sources from 1 keV to several 10 keV in the region, however, there may be a significant ionization by X-rays also. \vspace{0.1 in} We estimate the ionization rate due to X-rays based on the large scale ART-P X-ray map of the Galactic center region. 116.} The calculations proceed in two steps. First we allow for the attenuation of the observed X-rays by the foreground gas to obtain the original intensities of the X-ray sources. 119.} We then use the corrected X-ray flux to calculate ionization rates of H in the CMZ. The calculation is also related to the heating of the gas by X-rays. Discussion of the details of calculations and the results will be presented
Fusion of 60Ni + 100Mo below barrier
No full textThe fusion cross section of 60Ni + 100Mo has been measured down to microbarn level, looking for hindrance at low energy, in a system with positive Q-values for neutron transfer. The measured cross sections look similar to those of the nearby 64Ni + 100Mo, but no conclusive statement can be made at this stage, as to the onset of hindrance in this system
Genetic control of prophage induction in Haemophilus influenzae after exposure to psoralen plus near-UV light
No full textProphage S2 could be induced by psoralen plus near-UV light (PNUV) from a wild-type strain of Haemophilus influenzae, from UV light-sensitive strains uvr-1 and uvr-2 and PNUV-sensitive strains PSO1 amd PSO7, but not from a recombination-deficient strain, rec-1. The levels of prophage induction were comparable in the wild type and an ATP-dependent DNase-deficient strain, KW31, even though the PNUV-induced degradation in the latter strain was considerably lower. Prophage induction could be observed even with chloramphenicol present before, during, and 30 min after PNUV treatment
Genetic control of prophage induction in Haemophilus influenzae after exposure to psoralen plus near-UV light
No full textProphage S2 could be induced by psoralen plus near-UV light (PNUV) from a wild-type strain of Haemophilus influenzae, from UV light-sensitive strains uvr-1 and uvr-2 and PNUV-sensitive strains PSO1 amd PSO7, but not from a recombination-deficient strain, rec-1. The levels of prophage induction were comparable in the wild type and an ATP-dependent DNase-deficient strain, KW31, even though the PNUV-induced degradation in the latter strain was considerably lower. Prophage induction could be observed even with chloramphenicol present before, during, and 30 min after PNUV treatment
Fusion hindrance for Al27+Sc45 and other systems with a positive Q value
No full textFusion evaporation cross sections for the Al27+Sc45 (Q=9.63 MeV) system are measured down to about 300 nb. Deviations from standard coupled-channels calculations were observed in this system at the lowest energies. The steep fall-off of the fusion cross sections can be reproduced by calculations using a shallow potential model, which was originally developed to explain the hindrance behavior of heavy-ion fusion in medium-mass systems with negative Q values. Comparisons of the hindrance behavior between the present experiment and other systems, for example, Si28+Si30 (Q=14.3 MeV) and S36+Ca48 (Q=7.55 MeV) are presented. © 2010 The American Physical Society.Fil: Jiang, C. L.. Argonne National Laboratory; Estados UnidosFil: Rehm, K. E.. Argonne National Laboratory; Estados UnidosFil: Esbensen, H.. Argonne National Laboratory; Estados UnidosFil: Back, B. B.. Argonne National Laboratory; Estados UnidosFil: Janssens, R. V. F.. Argonne National Laboratory; Estados UnidosFil: Collon, P.. University of Notre Dame; Estados UnidosFil: Deibel, C. M.. Michigan State University; Estados Unidos. Argonne National Laboratory; Estados UnidosFil: Digiovine, B.. Argonne National Laboratory; Estados UnidosFil: Figueira, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Argonne National Laboratory; Estados Unidos. Laboratorio Tandar; ArgentinaFil: Greene, J. P.. Argonne National Laboratory; Estados UnidosFil: Henderson, D. J.. Argonne National Laboratory; Estados UnidosFil: Lee, H. Y.. Los Alamos National Laboratory; Estados Unidos. Argonne National Laboratory; Estados UnidosFil: Notani, M.. University of Notre Dame; Estados UnidosFil: Marley, S. T.. Argonne National Laboratory; Estados Unidos. Western Michigan University; Estados UnidosFil: Pardo, R. C.. Argonne National Laboratory; Estados UnidosFil: Patel, N.. Argonne National Laboratory; Estados Unidos. Colorado School Of Mines; Estados UnidosFil: Seweryniak, D.. Argonne National Laboratory; Estados UnidosFil: Tang, X. D.. University of Notre Dame; Estados UnidosFil: Ugalde, C.. Argonne National Laboratory; Estados UnidosFil: Zhu, S.. Argonne National Laboratory; Estados Unido
Mutagenicity of six Indian hair dyes tested in Salmonella typhimurium strains
No full textThis article does not have an abstract
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