323 research outputs found
Impact of COVID-19 lockdown on sleep in children with autism spectrum disorders
No full textSTUDY OBJECTIVES: The impact of the COVID-19 outbreak on sleep of participants with autism spectrum disorder (ASD) was assessed. METHODS: Parents of 111 children and adolescents with ASD filled out an anonymous online survey shared via social media, investigating the sleep patterns and disturbances before and during the lockdown. RESULTS: The lockdown changed significantly the bedtime on weekdays in 57.8% of participants with ASD (56.9% delayed; 0.9% advanced) and the rise time in 69.2% (61.7% delayed and 7.5% advanced). Sleep duration varied on weekdays in 49.1% (24.1% increased; 25% decreased). During the lockdown, participants with ASD showed a significant increase of sleep disturbances, compared to the preceding period, especially falling asleep (35.1% vs 22.5%), anxiety at bedtime (22.5% vs 10.8%), sleep terrors (5.4% vs 0%), and daytime sleepiness (14.4% vs 3.6%). CONCLUSIONS: Lockdown affected sleep of patients with ASD, showing an increase of difficulty in falling asleep, anxiety at bedtime, sleep terrors, and daytime sleepiness. The outbreak of COVID-19 significantly worsened sleep disturbances of children with ASD. CITATION: Bruni O, Melegari MG, Breda M, et al. Impact of COVID-19 lockdown on sleep in children with autism spectrum disorders. J Clin Sleep Med. 2022;18(1):137-143
Populismo come adattamento. Note critiche sull’analisi laclausiana della Lega Nord
No full textPopulismo come adattamento. Note critiche sull’analisi laclausiana della Lega Nor
Transsexualism: Nosological, legal and psychiatric aspects
No full textTranssexualism is manifested by a strong and persistent cross-gender identification and the desire to adapt the body to the preferred sex by hormonal and surgical sex reassignment. In Italy (as in many other countries), transsexuals can now be lawfully treated and psychiatrists can be called by a judge to execute an expert's report for allowing surgical operation (L. 164/1982). In this article, the authors examine the current concept of Gender Identity Disorder (GID) and try to deal with the still-open nosological and legal-psychiatric disptutes to facilitate consultant's work
Clozapine-induced microscopic colitis: A case report and review of the literature
No full textBoth diarrhea and colitis associated with clozapine have been reported. In this article, the authors present a case of clozapine-induced microscopic colitis (MC)-the first reported in the literature. The definitive diagnosis was suggested on colon biopsy, which showed an intraepithelial lymphocytosis (with >20 lymphocytes for every 100 epithelial cells) more striking in the surface epithelium than in the crypts. In addition, there were a mixed inflammatory infiltrate in the lamina propria (with lymphocytes predominating over eosinophils and neutrophils), an architecturally preserved colonic mucosa (particularly in the crypts), and a subepithelial collagen band normally thickened (<10 μm). Clozapine was thought to be the culprit and discontinued. After some days, the patient gradually improved. Diarrhea and spiking fever disappeared within 72 hours. Multiple colon biopsies taken after 7 days from the discontinuation of the clozapine revealed no abnormal histological findings. It is important to clarify the issue of clozapine-induced MC because MC may require the use of expensive or potentially toxic treatments and can occasionally be life-threatening (eg, hypokalemia). Thus, any case of MC that can be cured by withdrawal of the clozapine must be investigated and identified. © 2007 Lippincott Williams & Wilkins, Inc
Discussione del volume “Foucault”, Carocci 2017 (autori: M. Iofrida, D. Melegari, L. Paltrinieri)
No full textDiscussione del testo su Foucault, per l’editore Carocci, collana “Pensatori”, autori Iofrida, Melegari e Paltrinier
Aspects of NMR Characterization of Metallacrowns
No full textMetallacrowns (MCs) are self-assembled metallamacrocycles that confine a significant number of metal ions and organic ligands in a small molecular volume. These assembled structures present a cavity that can selectively encapsulate specific metal ions which provide MCs with peculiar spectroscopic features and reactivity. Also, MCs can bind inorganic and organic anions allowing their use in strategies of molecular recognition. For these reasons, including remarkable stability and inertness toward disassembly and the presence of paramagnetic ions in their structure, MCs possibly are among the most interesting metallamacrocyclic complexes known to date. The elucidation of dynamic processes of ligand and solvent exchange in solution is pivotal in the study of MCs as potential probes in biological imaging, as nanoshuttles for drug delivery or in molecular recognition and sensing. In this chapter, we will present and discuss representative examples of NMR investigations of metallacrowns reactivity, dynamics of assembly, and cations/anions binding. The strategies and conditions employed in the 1D NMR characterization of MCs will be discussed along with the most recent PGSE approaches. Also, we will discuss how the paramagnetic nature of these complexes opens a window into the study of their structure in solution through NMR
Novel Vacuum Evaporated Cavitand Sensors for Detecting Very Low Alcohol Concentrations
No full textHigh vacuum evaporation (VE) is used for the first time to grow thin films of novel tetraphosphonate, Tiiii[H, CH3, Ph], and tetrathiophosphonate, TSiiii[H, CH3, Ph], cavitands for gas sensing applications. The sensing capabilities of the samples were investigated by exposing Tiiii- and TSiiii-coated QCMs to very low concentrations of ethyl alcohol. The sensitivity, the speed (t50 = 5 s for both the samples) and the detection limit (0.4 ppm for Tiiii and 2.5 ppm for TSiiii) of the samples were determined, indicating highly competitive sensing capabilities. © 2010 Springer Science+Business Media B.V
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