1,721,156 research outputs found
L'articolazione del modello decisionale per la valutazione tecnico-economica dell'ADI
No full textSinergie, Anno XXIII, Rapporti di ricerca, n° 20 - Dicembre 2005 - ISSN 0393-510
A Comparative Study the Regional Accrediting Associations
No full textIn the practical administration of secondary schools and colleges today, there is no more potent factor than the five regional accrediting associations. For high school superintendents as well as for college officials these associations set standards which must be met and maintained by their respective institutions. In the educational world there are aristocratic agencies prescribing certain standards and creating a desire, or rather a demand on the part of schools, colleges, and universities to meet these requirements provided they wish to command consideration among institutions of learning. |The United States and Panama are now divided among five regional associations, viz: The North Central Association of Colleges and Secondary Schools, Association of Colleges and Secondary Schools of the Southern States, Northwest Association of Colleges and Secondary Schools, Association of Colleges and Secondary Schools of the Middle States and Maryland, The New England Association of Colleges and Secondary Schools.ProQuest Traditional Publishing Optio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
BIOLOGICAL ROLE OF OSTEOACTIVIN, A PROTEIN EXPRESSED BY TUMOR-CONDITIONED MACROPHAGES, IN THE PROCESSES OF TUMOR GROWTH AND TISSUE REPAIR
Full text linkTumor-Associated Macrophages (TAM) are key orchestrators of the tumor microenvironment, directly affecting neoplastic cell growth, neo-angiogenesis, extracellular matrix remodeling and immunosuppression. In a gene profiling analysis on tumor-conditioned macrophages cultured in vitro with tumor cell supernatants, we identified a number of up-regulated genes. One of the most expressed gene was Gpnmb, coding for a protein called Human Glycoprotein non-metastatic melanoma protein B (GPNMB), also named Osteoactivin (OA). Osteoactivin is a trans-membrane and shed molecule with diverse biological functions, spanning from cell adhesion and migration, to immune-suppression and tissue repair. This study investigates the modulation of this protein and its functional role in monocytes/macrophages and TAM, in the tumor context. In human monocytes, expression of OA is up-regulated by anti-inflammatory stimuli, in particular IL-10, and corticosteroids. Immunostimulatory cytokines (IFNγ, IL-1β) or LPS are not stimulating its production. Accordingly, in vitro M2-polarized macrophages express more OA than M1-macrophages.
A spontaneous mutation of the Gpnmb gene occurred in the DBA/2J mouse strain. The mutation causes a premature stop codon and generation of a truncated non-functional protein. This strain, and the reconstituted DBA/2J-Gpnmb+ mice with functional OA, are commercially available. OA-defective mice do not have obvious major problems, with the exception of the known rapid onset of glaucoma.
To clarify the role of this protein in the tumor microenvironment, we generated methylcolantrene-induced fibrosarcoma in these mice. Both mouse strains produced tumors with a similar incidence. We established and characterized 2 cell lines from DBA/2JGpnmb+ mice and 2 from DBA/2J mice. Tumors from DBA/2J mice grew earlier in DBA/2JGpnmb+ mice, indicating that the protein Osteoactivin produced by stromal cells, including TAM, enhanced tumor growth. To better understand the function of this protein, we generated isogenic cell lines expressing or not the functional OA protein (G2 OA and G2 MOCK cells). Osteoactivin -expressing cells grew faster in vitro and under serum-free conditions were able to survive and to form spheroids which go on proliferating in an anchorage-independent manner. OA-expressing cells present typical cancer stem cell markers on their membranes such as Sca1, CD117 and SOX-2 and they are able to self-renew. The in vivo experiments demonstrated that Osteoactivin expression is associated with a significantly more aggressive phenotype, both in terms of tumor-take and tumor growth compared to OA-defective cell lines. We further demonstrated that OA-expressing tumors have higher mRNA levels of specific stem markers and in particular Nanog, SOX-2 and Brachyury.
From these data we can speculate that the production of Osteoactivin and its secretion by macrophages in the tumor microenvironment might be involved in the maintenance of cancer cell stemness and their proliferative potential
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
L’interazione tra politici e manager nei processi contabili: quali ruoli? Quali ambiti di integrazione?
No full textIl modello burocratico di pubblica amministrazione, basato sulla supremazia dei politici, è stato ribaltato nel modello proposto dal NPM, nel quale è affermata la “supremazia dei manager”. Il presente lavoro si propone di investigare tramite un’analisi di casi multipli: (i) come politici e manager percepiscono la loro interazione e i rispettivi ruoli durante il processo di bilancio; (ii) quali variabili possono essere rilevanti al fine di spiegare tali percezioni e comportamenti. Dall’analisi svolta non emerge un modello dicotomico della relazione tra politici e dirigenti. Piuttosto, le loro relazioni possono essere lette in termini di integrazione sequenziale, di condivisione e in alcuni casi di “confusione”. Il contesto organizzativo, la tipologia dell’attività svolta dal settore e i fattori individuali sembrano essere in grado di influenzare il ruolo rispettivamente svolto da politici e dirigenti
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