163 research outputs found
Evolution of Eukaryal and Archaeal Pseudouridine Synthase Pus10
No full textFitzek E, Joardar A, Gupta R, Geisler M. Evolution of Eukaryal and Archaeal Pseudouridine Synthase Pus10. Journal of Molecular Evolution. 2018;86(1):77-89
Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling
No full textCadmium (Cd) imparts nephrotoxicity via triggering oxidative stress and pathological
signal transductions in renal cells. The present study was performed to explore the protective
mechanism of carnosic acid (CA), a naturally occurring antioxidant compound, against cadmium
chloride (CdCl2)-provoked nephrotoxicity employing suitable in vitro and in vivo assays. CA (5 M)
exhibited an anti-apoptotic effect against CdCl2 (40 M) in normal kidney epithelial (NKE) cells
evidenced from cell viability, image, and flow cytometry assays. In this study, CdCl2 treatment enhanced
oxidative stress by triggering free radical production, suppressing the endogenous redox defence system,
and inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2) activation inNKE cells andmouse kidneys.
Moreover, CdCl2 treatment significantly endorsed apoptosis and fibrosis via activation of apoptotic
and transforming growth factor (TGF)-1/mothers against decapentaplegic homolog (Smad)/collagen
IV signalling pathways, respectively. In contrast, CA treatment significantly attenuated Cd-provoked
nephrotoxicity via inhibiting free radicals, endorsing redox defence, suppressing apoptosis, and inhibiting
fibrosis in renal cells in both in vitro and in vivo systems. In addition, CA treatment significantly
(p < 0.05–0.01) restored blood and urine parameters to near-normal levels in mice. Histological findings
further confirmed the protective role of CA against Cd-mediated nephrotoxicity. Molecular docking
predicted possible interactions between CA and Nrf2/TGF-1/Smad/collagen IV. Hence, CA was found to
be a potential therapeutic agent to treat Cd-mediated nephrotoxicity
Cytoprotective and Antioxidant Effects of an Edible Herb, Enhydra fluctuans Lour. (Asteraceae), against Experimentally Induced Lead Acetate Intoxication.
No full textBACKGROUND:Enhydra fluctuans Lour. (Asteraceae), an edible aquatic herb, is traditionally employed against toxic effects of heavy metals in India. The present study was planned to discover the protective effect of edible extract of E. fluctuans (AEEF) against Pb toxicity. METHODS:The cytoprotective role of AEEF was determined on murine hepatocytes employing MTT assay and Hoechst staining. The effects on lipid peroxidation, protein carbonylation, endogenous redox systems and the transcription levels of apoptotic proteins were studied after incubating the hepatocytes with AEEF (400 μg/ml) + Pb-acetate (6.8 μM). The defensive role of AEEF (100 mg/kg) against Pb-acetate (5 mg/kg) intoxication was measured in mice by in vivo assays. Biochemical, haematological and histological parameters, intracellular Pb burden and redox status were measured. RESULTS:AEEF exhibited a concentration dependent cytoprotective effect against Pb-induced cytotoxicity in vitro. Pb-acetate incubation significantly (p < 0.01) altered the extents of ROS production ↑, protein carbonylation ↑, lipid peroxidation ↑, endogenous antioxidant enzymes ↓ and GSH ↓ in vitro. Besides, Pb-acetate significantly (p < 0.01) induced apoptosis in the hepatocytes apparent from the altered expressions of apoptotic proteins viz. Apaf-1 ↑, Bad ↑, Bcl-2 ↓, Cyt C ↑, cleaved caspases↑, Bid ↑ and Fas ↑. However, AEEF (400 μg/ml) could significantly (p < 0.05-0.01) attenuate the Pb-acetate mediated toxic manifestation in vitro. In in vivo assay, Pb-acetate (5 mg/kg) treated mice exhibited significantly (p < 0.01) high intracellular Pb content. A high Pb-burden within the tissues caused significant (p < 0.05-0.01) patho-physiological alterations viz. ROS production ↑, protein carbonylation↑, lipid peroxidation ↑, DNA fragmentation ↑, ATP formation ↑, mitochondrial co-enzymes Q ↓, endogenous antioxidant enzymes ↓ and GSH ↓ within the selected tissues. The haematological and serum biochemical parameters were significantly (p < 0.05-0.01) different in the Pb-acetate treated mice. Finally, histological assessment imposed significant toxic occurrence within the organs of Pb-intoxicated animals. However, concurrent administration of AEEF (100 mg/kg) could significantly (p < 0.05-0.01) reinstate the Pb-acetate mediated toxicity. CONCLUSION:Presence of metal chelators and phyto-antioxidants within AEEF would offer overall protection through promoting Pb clearance coupled with restoring redox balance
Non-existence of faithful isometric action of compact quantum groups on compact, connected Riemannian manifolds
No full textSuppose that a compact quantum group Q acts faithfully on a smooth, compact, connected manifold M, i.e. has a C* (co)-action α on C(M), such that the action α is isometric in the sense of [GOS09] for some Riemannian structure on M. We prove that Q must be commutative as a C* algebra i.e. Q≅ C(G) for some compact group G acting smoothly on M. In particular, the quantum isometry group of M (in the sense of [GOS09]) coincides with C(ISO(M))
Longitudinal Vortex Generation to Enhance the Performance of Compact Heat Exchangers: Flow and Heat Transfer Behavior for Plain and Interrupted Fins
No full text210 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.The numerical results are used to guide the first full-scale implementation of a VG-enhanced multi-louver heat exchanger. The heat transfer and pressure drop performance under both dry- and wet-surface conditions were determined through wind-tunnel experiments. Average heat transfer enhancements of 21% for dry conditions and 23% for wet conditions are achieved for 200≤ Re≤550, with a pressure drop penalty smaller than 7%.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD
Longitudinal Vortex Generation to Enhance the Performance of Compact Heat Exchangers: Flow and Heat Transfer Behavior for Plain and Interrupted Fins
No full textThe numerical results are used to guide the first full-scale implementation of a VG-enhanced multi-louver heat exchanger. The heat transfer and pressure drop performance under both dry- and wet-surface conditions were determined through wind-tunnel experiments. Average heat transfer enhancements of 21% for dry conditions and 23% for wet conditions are achieved for 200≤ Re≤550, with a pressure drop penalty smaller than 7%.Made available in DSpace on 2015-09-25T21:12:32Z (GMT). No. of bitstreams: 2
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Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDsRestricted to the U of I community idenfinitely during batch ingest of legacy ETDsU of I Only210 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007
DR. WALTER HALLSTEIN PART III #31.
No full textRepository: Booth Family Center for Special Collections. For more information about this collection please email: [email protected] of address by Walter Hallstein, Secretary of State for Foreign Affairs for Germany, in McDonough Gymnasium. Playing of the Alma Mater begins at the 9 minute, 53 second mark. This followed by a portion of a Georgetown University Forum program broadcast on September 20, 1953 and titled: The Kashmir Problem. The voices of Khalife Shujauddin, Member, Punjab Legislative Assembly, Noni Gopal Dev Joardar, Lecturer in History, Graduate School, Georgetown University, John Stanwell Fletcher, explorer, author and lecturer, and Matthew Warren, Forum Moderator, can be heard
An averaging trick for smooth actions of compact quantum groups on manifolds
No full textWe prove that, given any smooth action of a compact quantum group (in the sense of [9]) on a compact smooth manifold satisfying some more natural conditions, one can get a Riemannian structure on the manifold for which the corresponding C∞(M)-valued inner product on the space of one-forms is preserved by the action
Metal complexes of sulphur-nitrogen chelating agents. III. 2-aminocyclo-pentene-l-dithiocarboxylic acid complexes of Cr(III), Fe(III), Co(III), Fe(II) and Co(II)
No full textWith 2-aminocyclopentene-l-dithiocarboxylic acid (ACDA) complexes of the type M(ACDA)2 · nH2O (Co(II), N = 3; Fe(II), N = 2), Cr(ACDA)3 · 4H2O and M(ACDA)3 (Fe(III) and Co(III)) have been prepared. The compounds have been characterized from their infrared and electronic spectra, magnetic moment and thermal analysis. The Co(II) complex is of square planar configuration. The i.r. spectra suggest that in the Fe(II) and Fe(III) complexes bonding take place from (N,S-) donor sites of the ligand and in the Co(II), Co(III) and Cr(III) complexes disulphur chelation occur. The electronic spectra of the latter two complexes support this view. The Fe(II) complex is probably polymeric in nature
Metal complexes of sulphur-nitrogen chelating agents. I. 2-aminocyclo-pentene-l-dithiocarboxylic acid complexes of Ni(II), Pd(II) and Pt(II)
No full textThe Ni(II), Pd(II) and Pt(II) chelates of 2-amino- cyclopentene-l-dithiocarboxylic acid (ACDA) are described. With each metal ions, two differently colored products having identical composition M(ACDA)2 are obtained when reactions are carried out with the acid itself and its ammonium salt. PMR spectra of ACDA indicates strong hydrogen bonding between one amino proton and thiocarbonyl sulphur atom. The nature of bonding in the complexes have been investigated from their i.r, pmr and electronic spectra, magnetic moment, thermal analysis and X-ray diffraction data. In all the chelates bonding with metal ions occur through amino nitrogen and deprotonated thiolsulphur. The stability constant of Ni-ACDA complex has been evaluated spectrophotometrically. Ni(ACDA)2 forms a 1:2 adduct with pyridine. The color difference in the chelates probably arises due to geometrical isomerism
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