1,721,214 research outputs found
HBV infection and hepatocellular carcinoma
No full textThe hepatitis B virus (HBV) plays a dominant role in the 749,000 new cases and 692,000 deaths related to hepatocellular carcinoma (HCC) that are estimated to occur each year worldwide. Chronic infection with HBV is responsible for 60% of HCCs in Asia and Africa and at least 20% of the tumors in Europe, Japan, and the United States. This article discusses the pathogenic role of HBV and the risk of HCC. Tumors almost invariably develop in the context of chronic hepatitis or cirrhosis, which makes early diagnosis the only practical approach to improve prognosis. The treatment options are also discussed
Compatible Adaptive Learning Shared System. Il modello CALSS: compatibilità ed efficacia per la produzione di economie della conoscenza
No full textRelazione nel I Workshop nazionale per il progetto FIRB Nuove tecnologie per la formazione permanente e reti nel sistema socioeconomico italiano (coordinatore nazionale prof. Paolo Orefice) finanziato dal MIUR, Dipartimento per la Programmazione il Coordinamento e gli Affari Economici, SSPAR, PNR 2001-2003 (FIRB art.8) D.M. 199 Ric. del 8 marzo 2001
HBV-related HCC, clinical issues and therapy
No full textEvery year, more than 600 thousand persons will develop hepatocellular carcinoma (HCC) worldwide. Sixty percent of all HCCs in Asia and Africa are related to chronic infection with the hepatitis B virus (HBV) compared to only 20% of HCC cases in Europe, Japan and USA. Surveillance of chronically infected patients improves treatment of HCC, since it helps detecting tumors amenable to radical therapies. In cirrhotic patients, HCC can be confidently diagnosed by contrast imaging techniques, albeit the accuracy of radiological diagnosis is largely influenced by tumor size. Hepatic resection and liver transplantation are the first therapeutic options for patients within Milan criteria. The long-term outcome of resection, however, is affected by high risk of tumor recurrence, whereas liver transplantation has a negligible risk of both HBV and HCC recurrence-related anticipated mortality. The clinical benefits of loco-regional ablative techniques are evidence based for patients with less than 3 cm tumors only, whereas the standard of care for intermediate tumors, chemoembolization, needs to be validated in view of new technical improvements. Tertiary prevention of HCC in patients with established HBV infection is doubtful, mainly due to methodological weaknesses of studies based on interferon and nucleos(t)ide analogues therap
Genitorialità migrante: un’esperienza di formazione interculturale con madri immigrate a Napoli
No full textOur contribution is as theoretical and methodological reflection on the specific phenomenon
of new immigrant, interfaith families. Some questions were asked about this matter:
what happens within these families? Are identity and origin of each parent important
predictors of children’s educational models? Which of the two lineages prevails: motherhood
or fatherhood? What paths of parenting? Are there differences of gender? These
questions will have only partial answers in this reflection; however, our aim is to develop
a pedagogical model of the phenomenon, through the description of an educational
practice. In terms of education quality, the first question that arises is to bring together these multiplicities and differences within an educational model, whose characteristics
of stability, consistency and functionality may help to avoid the risk of confusion and
disorientation in subjects who live in real-life complex situations
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