228 research outputs found

    Knowledge of number

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    The author of Knowledge and the Philosophy of Number (2020), Keith Hossack, Professor of Philosophy at Birkbeck, University of London, explains in this article something that seems very elementary, but which is enormously complex for a layman: what is a number, what counting is and how the infinite amount of numbers is analogous to the mind of God, the supreme mathematician

    Estimated central blood volume in cirrhosis

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    The estimated central blood volume (i.e., blood volume in the heart cavities, lungs and central arterial tree) was determined by multiplying cardiac output by circulatory mean transit time in 19 patients with cirrhosis and compared with sympathetic nervous activity and circulating level of atrial natriuretic factor. Arterial norepinephrine level, an index of overall sympathetic nervous activity (3.08 nmol/L in patients vs. 1.36 nmol/L in controls; p < 0.01) was negatively correlated (r = -0.54, p < 0.01) with estimated central blood volume (mean = 23 ml/kg in patients vs. 27 ml/kg in controls; p < 0.05). Similarly, renal venous norepinephrine level (an index of renal sympathetic tone; 4.26 nmol/L in patients vs. 1.78 nmol/L in controls; p < 0.01) was inversely correlated with estimated central blood volume (r = -0.53, n = 18, p < 0.02). No significant correlation could be established between arterial atrial natriuretic factor level (8.9 pmol/L in patients vs. 9.6 pmol/L in controls; not significant) and estimated central blood volume. Hemodynamic values were subsequently modified with oral propranolol (80 mg). During -adrenergic blockade, the mean estimated central blood volume was not altered significantly, except in six patients who exhibited decreases in mean arterial blood pressure (85 to 69 mm Hg; n = 6) and decreases in mean estimated central blood volume (23.2 to 20.6 ml/kg; n = 6, p < 0.05). Slight increases were observed in mean right atrial pressure (2.2 to 3.7 mm Hg; n = 14, p < 0.05); this change was positively correlated with the change in estimated central blood volume (r = 0.44, n = 14, p = 0.06). In conclusion, reduced estimated central blood volume probably unloads volume receptors and baroreceptors, thus provoking enhanced overall and renal sympathetic nervous activity and thereby contributing to increased water and salt retention in cirrhosis. During -adrenergic blockade estimated central blood volume changes correlated with alterations in preload and afterload. These findings indicate that central circulatory and arterial underfilling is a key element of the hemodynamic derangement observed in cirrhosis

    Dr. David Hossack, New York

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    Issues in integrating existing multi-agent systems for power engineering applications

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    Multi-agent systems (MAS) have proven to be an effective platform for diagnostic and condition monitoring applications in the power industry. For example, a multi-agent system architecture, entitled condition monitoring multi-agent system (COMMAS) (McArthur et al., 2004), has been applied to the ultra high frequency (UHF) monitoring of partial discharge activity inside transformers. Additionally, a multi-agent system, entitled protection engineering diagnostic agents (PEDA) (Hossack et al., 2003), has demonstrated the use of MAS technology for automated and enhanced post-fault analysis of power systems disturbances based on SCADA and digital fault recorder (DFR) data. In this paper, the authors propose the integration of COMMAS and PEDA as a means of offering enhanced decision support to engineers tasked with managing transformer assets. By providing automatically interpreted data related to condition monitoring and power system disturbances, the proposed integrated system offer engineers a more comprehensive picture of the health of a given transformer. Defects and deterioration in performance can be correlated with the operating conditions it experiences. The integration of COMMAS and PEDA has highlighted the issues inherent to the inter-operation of existing multi-agent systems and, in particular, the issues surrounding the use of differing ontologies. The authors believe that these issues need to be addressed if there is to be widespread deployment of MAS technology within the power industry. This paper presents research undertaken to integrate the two MAS and to deal with ontology issues

    Concept and content

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    Book synopsis: Spanning the breadth of philosophical, historical and theological interests articulated in the work of Paul Helm, including chapters on Calvinism, philosophical theology, philosophy of mind, Christian Doctrine and epistemology, Reason, Faith and History offers an accessible text for students of contemporary philosophy of religion as well as those interested in philosophical theology more broadly. Reason, Faith and History offers a unique collection of essays on key topics in the philosophy of religion. Published in honour of Paul Helm, a major force in contemporary English-speaking philosophy of religion, this book presents newly commissioned chapters by distinguished philosophers and theologians from North America, Israel, the UK and Continental Europe
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