1,513 research outputs found
Site characterization and preliminary ground response analysis for the monumental Complex of SS. Annunziata in Sulmona, Italy
No full textThe historical building Complex of the SS. Annunziata in Sulmona (L’Aquila, Italy), consists of a church and an adjoining building. It overlooks the square of the same name along the main street of the historic centre of the town. SS. Annunziata is considered the most important historical monument in Sulmona, not only for its huge artistic and architectural value, but also for the special significance it had in the social and political life of the city. The construction of the Complex started in the 14th century and continued for centuries. The long building duration led the Complex to take on its current appearance characterized by different architectural styles: Late Gothic, Renaissance and Baroque. As a result of earthquakes that affected the area, the various buildings that are (or were) part of the monumental Complex suffered damage (perhaps in 1349, 1456 and certainly in 1706) and underwent major reconstruction works. Significant damage was also caused to the structures of the SS. Annunziata Complex by the earthquakes that struck the central Apennines in the 20th century (i.e. 1915 and 1933) and by the 2009 L'Aquila earthquake. After this latter, the damage observed to the rear of the buildings in the monumental Complex was more severe than those of the front. To verify whether the subsoil local conditions can explain the distribution of the observed damage, studies of ground response have been planned at the site where SS. Annunziata Complex is located. This work presents the preliminary results of the case study. After a general overview of the Sulmona basin and the SS. Annunziata Complex, the results of the survey carried out in the study area are described and analyzed, aimed at defining the geotechnical model. The results of numerical 1D analyses performed on soil profiles, representative of the subsoil conditions both at the front and back of the historical Complex, are also presented and compared
Nitroacrylates reactivity In stereoselective organocatalyzed cascade reactions
No full textNitroacrylates are pluripotent substrates that have already found interesting applications as electrophiles in anti-Michael additions as well as dienophiles in Diels Alder reactions.(1)
Our group has recently reported the possibility of obtaining cyclohexanone derivatives by a stereoselective organocatalyzed one-pot methodology from (E)-beta-subsituteted-beta-nitroacrylates and alfa,beta-unsaturated ketones.(2) The so obtained products are direct precursors of cyclic beta-amino acids and can be seen as advanced intermediates for the synthesis of beta-lactams or natural products. The reaction is promoted by Cinchona alkaloids derived primary amines in the presence of an acidic co-catalyst and afford two diasteroisomers in high yield - typically 80% - and enantiomeric excess up to 98%.(3)
Replacing traditional heating with microwave irradiation afforded cleaner reactions in shortened time, passing from 48 hours to 30 minutes, with improved dr (20:80) and high ee (up to 94%).
The application of microwave technology to this organocatalytic methodology allowed also employing C1 substituted enones, leading to cyclohexanones with four contiguous stereocenters with enantioselectivity exceeding 93%, although in low yield and diasteromeric ratio. Solvent and temperature effect were investigated, but no substantial changes the reaction outcome were observed. The combination of different substitution patterns on both reaction partners is still under investigation, so to obtain densely functionalized cyclic nitro esters with high selectivity.
References:
1 Jensen, K. L.; Dickmeiss, G.; Donslund, B. S.; Poulsen, P. H.; Jorgensen, K. A. Org. Lett., 2011, 13, 14, 36782; Mukherjee, S., Corey, E. J. Org. Lett., 2010, 12, 5, 1024.
2 Massolo, E.; Benaglia, M., Annunziata, R; Palmieri, A; Celentano, G; Forni, A. Adv. Syn. Catal. 2014, 356, 493-500.
3 For a related work see: Wu, L.-Y.; Bencivenni, G.; Mancinelli, M.; Mazzanti, A.; Bartoli, G.; Melchiorre, P. Angew. Chem. Int. Ed., 2009, 48, 7196-7199
Site characterization and preliminary ground response analysis for the monumental Complex of SS. Annunziata in Sulmona, Italy
No full textThe historical building Complex of the SS. Annunziata in Sulmona (L’Aquila, Italy), consists of a church and an adjoining building. It overlooks the square of the same name along the main street of the historic centre of the town. SS. Annunziata is considered the most important historical monument in Sulmona, not only for its huge artistic and architectural value, but also for the special significance it had in the social and political life of the city. The construction of the Complex started in the 14th century and continued for centuries. The long building duration led the Complex to take on its current appearance characterized by different architectural styles: late Gothic, Renaissance and Baroque. As a result of earthquakes that affected the area, the various buildings that are (or were) part of the monumental Complex suffered damage (perhaps in 1349, 1456 and certainly in 1706) and underwent major reconstruction works. Significant damage was also caused to the structures of the SS. Annunziata Complex by the earthquakes that struck the central Apennines in the 20th century (i.e. 1915 and 1933) and by the 2009 L'Aquila earthquake. After this latter, the damage observed to the rear of the buildings in the monumental Complex was more severe than those of the front. To verify whether the subsoil local conditions can explain the distribution of the observed damage, studies of ground response have been planned at the site where SS. Annunziata Complex is located. This work presents the preliminary results of the case study. After a general overview of the Sulmona basin and the SS. Annunziata Complex, the results of the survey carried out in the study area are described and analyzed, aimed at defining the geotechnical model. The results of numerical 1D analyses performed on soil profiles, representative of the subsoil conditions both at the front and back of the historical Complex, are also presented and compared
Citotoxicity and oxidative stress caused by dental adhesive system cured with halogen and LED lights
No full textIl CIBO TRA LOGICHE DI MERCATO E SOSTENIBILITA' DELLA PRODUZIONE
No full textIl lavoro intende descrivere le logiche organizzative del mercato agroalimentare contemporaneo utilizzando il concetto di radicamento che, nell’ultimo decennio, è stato sempre più impiegato dalle analisi sullo sviluppo locale e regionale. Nel sistema della grande produzione agroindustriale e della distribuzione organizzata, i processi di sradicamento che connotano le filiere lunghe hanno determinato una netta separazione tra luoghi, tempi e modi di produzione e consumo. Il modello “contadino” dell’agricoltura biologica e tradizionale che si è progressivamente affermato negli ultimi decenni ha cambiato il rapporto tra produzione e consumo di cibo, riportandolo alla fiducia reciproca, alle relazioni dirette e alla precisa informazione sulla qualità dei suoi prodotti. In questa prospettiva di analisi, si cercherà di rappresentare i processi di radicamento attivati nell’area campana del Cilento. I risultati dell’indagine confermano che l’istituzione del primo biodistretto italiano può costituire uno stimolo allo sviluppo insieme a una diffusione dell’immagine identitaria cilentana
The Impact of COVID-19 on Authoring Open Data Workshop Settings in High School
No full textAccording to the Open Knowledge Foundation, Open Data are data that can be freely used, created and shared by anyone. Initiatives to let K-12 learners exploit Open Data are rare in literature, and the situation is even worse if we look for opportunities to move them in the position of Open Data publishers. To advance the dialogue around methods to increase awareness of Open Data, improve users’ skills to author and use Open Data, HETOR regularly organises workshops with secondary school learners to let them create, publish, and exploit Open Data by SPOD since 2016. While workshops were organised as physical meetings, during the COVID-19 pandemic, HETOR required to revise the performed protocol. This article reports changes applied to the workshops proposed by HETOR and the observed results in terms of quantity and quality of produced open datasets, and quality of presenting and disseminating the authored Open Data by comparing workshops’ results before and after the COVID-19. According to the discussion, the quantity and quality of the workshops outcome increased during the workshops that took place after the COVID-19 pandemic demonstrating that Open Data based initiatives can successfully survive in remote settings. On the opposite, the quality of the presentations authored by scholars is more heterogeneous during after-COVID workshops demonstrating that remote settings make educational inequalities worse
BIOEROSION ON A TEREBRATULA SCILLAE POPULATION FROM THE LOWER PLEISTOCENE OF LECCE AREA (SOUTHERN ITALY).
No full textSalute del consumatore, produzioni biologiche e competitività: sfide ed opportunità per il settore agro-alimentare italiano
No full textDefining hospital anxiety and depression scale (HADS) structure by confirmatory factor analysis: a contribution to validation for oncological settings
No full textBackground: Despite its popularity, not a definitive word has yet been said about the latent structure of the Hospital Anxiety and Depression Scale (HADS). The present work is a contribution to this issue: statistically identifying the best tool structure helps in understanding which constructs the tool actually detects. Participants and methods: Five hundred and twelve Italian consecutive hospitalized cancer patients completed the HADS together with a form for the collection of personal and clinical data. Two confirmatory factor analyses (CFAs) were carried out to test the validity of both two- and one-factor models, whereas qualitative and quantitative (i.e. Akaike information criterion) indices were used to assess which model among them would fit better with the observed data. Finally, two multigroup CFAs were carried out to test the factorial invariance across gender and disease phase (diagnostic, therapeutic) of the best-fitting model. Results: Although both considered models provide a good fit to the observed data, the two-factor model is more adequate; it is invariant across gender and disease phase. Conclusions: The present study gives evidence for using HADS to detect anxious and depressive states separately as originally suggested by its authors. Given that this work involved only Italian cancer inpatients, replications in different cultural/national contexts are recommended. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved
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