1,720,976 research outputs found
La terapia radiante metabolica con 131I nelle tireopatie. Premesse metaboliche, fisiche, radiobiologiche
No full textL'azione terapeutica del radioiodio consiste nel cedere la sua energia provocando ionizzazioni lungo il percorso intracellulare delle radiazioni
Thyroid stunning in clinical practice: Is it a real problem?
No full textStunning is a phenomenon of reducing 131I uptaking activity by residual or metastatic tissue during the follow-up of patients after total thyroidectomy for differentiated thyroid carcinoma. It was observed at whole body scintigraphy performed after therapeutic dose, administered for remnant ablation, in patients who were previously given a 131I dose for diagnostic purpose. This phenomenon could influence the efficacy of radioisotopic therapy, making it unsuccessful. Stunning was observed also in case of hyperthyroidism treated by fractionated doses of 131I. After a careful revision of literature, Authors report their last 10 years-experience about very few cases of supposed stunning, observed in oncological and hyperthyroidal patients who underwent diagnostic scan and radioiodine therapy. In case of differentiated thyroid carcinoma, we recommended a careful selection of patients who will be given ablative therapy using very low diagnostic doses and administering further therapeutic dose in a short time. In case of hyperthyroidism treatment, it is confirmed the opportunity of a single therapeutic dose with TSH value within the normal range. Because it was found out a very small number of cases in our wide population, we conclude that stunning is not influent in clinical practice, above all if "well- practice" diagnostic-therapeutical procedures are strictly observed
Recidive locoregionali e metastasi a distanza: quali strumenti diagnostici?
No full textNel follow-up dei carcinomi tiroidei differenziati, che presentano netta prevalenza delle forme papillifere molto spesso a basso richio, il dosaggio della Tg e l'esame ecografico del collo sembrano oggi soddisfare le esigenze diagnostiche. L'esame scintigrafico corporeo globale (WBS) trova indicazione relativa in presenza di AbhTg e assoluta in caso di Tg elevata. La sensibilità di Tg e WBS aumenta significativamente con l'incremento dei valori del TSH. Un valido contributo di imaging può essere offerto da TC e PET in caso di metastasi non captanti il 131I.
In presenza di diagnsoi istologica di carcinoma midollare un ruolo fondamentale nel follow-up è assolto dal dosaggio della calcitonina, in condizioni di base e/o sotto stimolo della pentagastrina o del calcio, e da quello del CEA. Le comuni metodiche della diagnostica per immagini (ecografia, TC, RM, PET) possono essere utili in questi casi e in quelli con diagnosi di carcinoma anaplastico
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Carcinomi della tiroide. Incidenza e follow-up. Nostra esperienza
No full textI carcinomi della tiroide: differenziato, midollare, anaplastico. Dalla diagnosi al follow-up
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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