570 research outputs found
Single-molecule force spectroscopy: Heterogeneity of chemical bonds
No full textRaible M, Reimann P. Single-molecule force spectroscopy: Heterogeneity of chemical bonds. Europhysics Letters. 2006;73(4):628-634.We show that the standard theoretical framework in single-molecule force spectroscopy by Evans and Ritchie (Biophys. J., 72 (1997) 1541) has to be extended in order to consistently describe the experimental findings. The basic new concept is to take into account heterogeneity of the chemical bonds, resulting in excellent agreement between theory and experiment
Parents in science
No full textAs part of our Q&A series, Genome Biology spoke to four scientists about their personal experiences as parents in their careers to highlight the challenges of researchers having children and the support they need in this regard. Our participants also included a couple (Kristin Tessmar-Raible and Florian Raible), as we were interested to know whether both parents being active researchers can have an impact. One of our participants wishes to remain anonymous.© The Author(s) 201
Exact Elimination of Cycles in Graphs
No full textOne of the standard basic steps in drawing hierarchical graphs is to invert some arcs of the given graph to make the graph acyclic. We discuss exact and parameterized algorithms for this problem. In particular we examine a graph class called (1, n)-graphs, which contains cubic graphs. We discuss exact and parameterized algorithms, where we use a non-standard measure approach for the analysis. Especially the analysis of the parameterized algorithm is of special interest, as it is not an amortized analysis modelled by ’finite states’ but is rather a ’top-down’ amortized analysis. For (1, n)-graphs we achieve a running time of O ∗ (1.1871 m) and O ∗ (1.212 k), for cubic graphs O ∗ (1.1798 m) and O ∗ (1.201 k), respectively. As a by-product the the trivial bound of 2 n for Feedback Vertex Set on planar directed graphs is broken
Operation of a large GEM-MSGC detector in a high intensity hadronic test beam using fully pipelined readout electronics
No full text98-060 In a recent test beam experiment at PSI a new tracking device for very high particle fluxes consisting of a low gain micro strip gas chamber (MSGC) combined with a gas electron multiplier (GEM) foil has been run under beam conditions similar to those foreseen in the HERA-B experiment [1], where such devices are being installed for the inner tracker. They are also being evaluated for the LHCb experiment [2]. In both detectors very high, mainly hadronic particle densities (up to 10 4 mm -2 sec -1) are expected, while the momentum resolution of the magnetic spectrometers foreseen in the two experiments is limited by multiple scattering. Also photon conversions represent a significant background source and therefore a minimal thickness in terms of radiation length is important, while position resolution requirements are moderate (typically 300 mu m pitch is sufficient). This paper describes the detailed construction of this novel detector, the test beam configuration and some of the data taken using the full HERA-B readout electronics
Mobile and digital documentation of inpatient treatments. Use of personal digital assistants in addition with the ClinicCoach (c) software
No full textBackground. Documentation of the individual treatment course is essential from medical as well as economic and forensic aspects. With increasing hospital computerization the conventional hardcopy form of record keeping is seen to be associated with high outlays and restrictiveness. Methods. Clinicians engaged consistently in the development of a personal digital assistant (PDA)-based electronic record system (Clinic Coach (c)), which maps the entire course of inpatient treatments. The system's effectiveness was reviewed by means of a standardized questionnaire and analysis of 8,595 data sets relating to PPR and wound findings. Results. In patients undergoing surgery wound findings and PPR were documented in 83.6% and in 94.3% respectively. The ClinicCoach (c) System was rated more effective than paper-based documentation by 78.4% of the testing healthcare workers. Conclusion. The combination of PDAs and ClinicCoach (c) is a reliable and to clinical routine well adapted system that allows digital documentation at the bedside
"Littérature, philologie, linguistique : l'unité de la romanistique"
No full textFrank-Job B, Borreguero Zuloaga M, Gülich E, Raible W, Rastier F. "Littérature, philologie, linguistique : l'unité de la romanistique". In: Buchi É, Chauveau J-P, Pierrel J-M, eds. Actes du XXVIIe Congrès international de linguistique et de philologie romanes (Nancy, 15-20 juillet 2013). Bibliothèque de linguistique romane. Vol 14. Strasbourg: Editions de Linguistique et de Philologie /ÉliPhi; 2014
Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes
No full textRaible M, Evstigneev M, Reimann P, Bartels FW, Ros R. Theoretical analysis of dynamic force spectroscopy experiments on ligand-receptor complexes. Journal of Biotechnology. 2004;112(1-2):13-23.The forced rupture of single chemical bonds in biomolecular compounds (e.g. ligand-receptor systems) as observed in dynamic force spectroscopy experiments is addressed. Under the assumption that the probability of bond rupture depends only on the instantaneously acting force, a data collapse onto a single master curve is predicted. For rupture data obtained experimentally by dynamic AFM force spectroscopy of a ligand-receptor bond between a DNA and a regulatory protein we do not find such a collapse. We conclude that the above mentioned, generally accepted assumption is not satisfied and we discuss possible explanations. (C) 2004 Elsevier B.V. All rights reserved
Recommended from our members
Objective climatology of cyclones in the Mediterranean region: a consensus view among methods with different system identification and tracking criteria
No full textThe Mediterranean storm track constitutes a well-defined branch of the North Hemisphere storm track and is characterised by small but intense features and frequent cyclogenesis. The goal of this study is to assess the level of consensus among cyclone detection and tracking methods (CDTMs), to identify robust features and to explore sources of disagreement. A set of 14 CDTMs has been applied for computing the climatology of cyclones crossing the Mediterranean region using the ERA-Interim dataset for the period 1979–2008 as common testbed. Results show large differences in actual cyclone numbers identified by different methods, but a good level of consensus on the interpretation of results regarding location, annual cycle and trends of cyclone tracks. Cyclogenesis areas such as the north-western Mediterranean, North Africa, north shore of the Levantine basin, as well as the seasonality of their maxima are robust features on which methods show a substantial agreement. Differences among methods are greatly reduced if cyclone numbers are transformed to a dimensionless index, which, in spite of disagreement on mean values and interannual variances of cyclone numbers, reveals a consensus on variability, sign and significance of trends. Further, excluding ‘weak’ and ‘slow’ cyclones from the computation of cyclone statistics improves the agreement among CDTMs. Results show significant negative trends of cyclone frequency in spring and positive trends in summer, whose contrasting effects compensate each other at annual scale, so that there is no significant long-term trend in total cyclone numbers in the Mediterranean basin in the 1979–2008 period
Climate change impacts on tree species, forest properties, and ecosystem services
No full text– Swiss forests experience strong impacts under the CH2011 scenarios, partly even for the low greenhouse gas scenario RCP3PD. Negative impacts prevail in low-elevation forests, whereas mostly positive impacts are expected in high-elevation forests.
– Major changes in the distribution of the two most important tree species, Norway spruce and European beech, are expected. Growth conditions for spruce improve in a broad range of scenarios at presently cool high-elevation sites with plentiful precipitation, but in the case of strong warming (A1B and A2) spruce and beech are at risk in large parts of the Swiss Plateau.
– High elevation forests that are temperature-limited will show little change in species composition but an increase in biomass. In contrast, forests at low elevations in warm-dry inner-Alpine valleys are sensitive to even moderate warming and may no longer sustain current biomass and species.
– Timber production potential, carbon storage, and protection from avalanches and rockfall react differently to climate change, with an overall tendency to deteriorate at low elevations, and improve at high elevations.
– Climate change will affect forests also indirectly, e.g., by increasing the risk of infestation by spruce bark beetles, which will profit from an extended flight period and will produce more generations per year
- …
