1,723,410 research outputs found
Carlo M. Ferrari, ca. 1885
No full textPastor Carlo M. Ferrari, one of four Italian immigrant pastors to serve the Immaculate Conception Church between 1882 and 1929. Ferrari was born in Calabria, Italy and served from 1882 to 1889. (Photo courtesy of Immaculate Conception Catholic Church.
G. M. Ferrari — Scritti varj. — Roma, Società Dante, 1902
No full textDumesnil Georges. G. M. Ferrari — Scritti varj. — Roma, Società Dante, 1902. In: Revue internationale de l'enseignement, tome 56, Juillet-Décembre 1908. p. 379
G.-M. Ferrari, Disciplina scolastica educativa. Rome, Société d’édition Dante Alighieri, 1897
No full textRosenthal Léon. G.-M. Ferrari, Disciplina scolastica educativa. Rome, Société d’édition Dante Alighieri, 1897. In: Revue internationale de l'enseignement, tome 35, Janvier-Juin 1898. pp. 567-569
La cerimonia del comporre. Metodi e tecniche di composizione nei progetti urbani di Gianugo Polesello = The ceremony of composing. Methods and technics of composition in Gianugo Polesello urban projects
No full textL’obiettivo dell’attività di ricerca presentata è finalizzato a produrre una conoscenza
di tecniche e modalità della composizione urbana attraverso l’analisi e lo smontaggio di diversi progetti svolti dall’architetto friulano Gianugo Polesello. La ricerca si struttura per parti distinte privilegiando un ordine ipotattico bilanciato, a servizio dell’analisi dei progetti urbani, i quali sono il fulcro e il cardine strumentale della produzione di questa conoscenza.
Seppur con una loro diversità, le parti del lavoro proposto individuano un comune intento con cui costituire l’unità della tesi: il riconoscimento di un’idea di città a cui Polesello ambisce in ogni suo progetto attraverso una pratica ripetuta di tecniche ricorrenti (qui definita come cerimonia del comporre).
La prima parte introduce al tema del lavoro sulle forme e gli spazi inquadrando l’esperienza dell’architetto attraverso il riconoscimento di una genetica formale a partire dalle sue prime occasioni giovanili. Si mostra come vi sia una continuità nei temi di ricerca (oltre che alle tecniche) del progetto urbano avviata dal suo maestro Giuseppe Samonà nel contesto accademico veneziano.
La seconda parte, baricentro e nodo cruciale della presente tesi, avanza uno smontaggio critico di alcune selezionate occasioni progettuali elaborate da Polesello all’interno della sua carriera. La scelta dei progetti analizzati si propone più che per la natura delle componenti, quanto per le modalità con cui generare relazioni sul piano di progetto attraverso la dispositio delle figure architettoniche. L’individuazione delle invarianti di ogni area di progetto (topografia critica), la nominazione delle strutture fondative (fondazione del piano), le relazioni tra le parti di progetto e la loro combinazione all’interno del piano (invenzione di un ordine), l’analisi morfologica delle componenti in relazione alla loro collocazione (tipos/topos) costituiscono un armamentario tecnico con il quale indagare le composizioni.
La terza e ultima parte si occupa di illustrare i significati profondi degli strumenti figurativi con cui Polesello dispone le composizioni urbane: viene riconosciuta una tensione astrattiva di tipo iconico alle modalità ricorrenti del configurare, al di là dell’assemblare. Il senso delle operazioni trova nella composizione del “vuoto” urbano una matrice ideale a cui Polesello fa corrispondere forme e spazi. Attraverso il riconoscimento e l’identificazione delle tecniche di composizione è possibile rinnovare il valore dei sensi e dei significati della città dei nostri giorni.
Inoltre, la ricerca si avvale dell’utilizzo di un linguaggio grafico appropriato dato dalla rappresentazione in chiave astrattiva (lineare e stereometrica) rivolta ad un’interpretazione dei significati generali della figuratività che i progetti di Polesello possiedono.The goal of the follow research activity is aimed at producing a knowledge of techniques and modalities of Urban Composition through the analysis and disassembly of several projects carried out by the Friulian architect Gianugo Polesello. The research is structured by distinct parts privileging a balanced hypotactic order, serving the analysis of urban projects, which are the core and instrumental hinge of the production of this knowledge.
Although with their own diversity, the parts of the proposed work identify a common intent with which to constitute the unity of the thesis: the recognition of an idea of the city to which Polesello aspires in each of his projects through a repeated practice of recurring techniques (defined here as a ceremony of composing).
The first part introduces the theme of working on forms and spaces by focusing the architect’s experience through the formal genetic recognition from his early youthful occasions. It shows how there is a continuity in the research themes (as well as techniques) of Urban Design initiated by his master Giuseppe Samonà in the Venetian academia.
The second part, the barycenter and crucial issue of this thesis, makes a proposal for a critical disassembly of selected projects designed by Polesello within his career. The choice of the projects analyzed is proposed more for the nature of the components than for the ways in which they generate relationships on the design plane through the dispositio of architectural figures. The identification of the invariants of each project area (critical topography), the naming of the foundational structures (foundation of the plan), the relationships between the project parts and their combination within the plan (invention of an order), the morphological analysis of the components in relation to their location (tipos/topos) constitute a technical equipment with which to investigate the arrangements.
The third and final part is concerned with illustrating the deeper meanings of the figurative tools with which Polesello arranges urban compositions: an icon-like abstract tension is recognized in the recurring modes of shaping, beyond assembling. The sense of operations finds in the composition of the urban “void” an ideal matrix to which Polesello corresponds forms and spaces. Through the recognition and identification of compositional techniques, it is possible to renew the value of the senses and meanings of the nowadays city.
In addition, the research makes use of an appropriate language given by the representation in an abstract key (linear and stereometric) aimed at an interpretation of the general meanings of figurativeness that Polesello’s projects possess
N. Vaschide: Recherches expérimentales sur la mémoire des lignes. (En collaboration avec M. Ferrari.) III. intern. Congr. f. Psychol., S. 454-456
No full textN. VASCHIDE: RECHERCHES EXPÉRIMENTALES SUR LA MÉMOIRE DES LIGNES. (EN COLLABORATION AVEC M. FERRARI.) III. INTERN. CONGR. F. PSYCHOL., S. 454-456
Zeitschrift für Psychologie und Physiologie der Sinnesorgane (-)
Zeitschrift für Psychologie und Physiologie der Sinnesorgane (20) (a0006)
N. Vaschide: Recherches expérimentales sur la mémoire des lignes. (En collaboration avec M. Ferrari.) III. intern. Congr. f. Psychol., S. 454-456 (20) (p0211
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Innovative ferritin nanocages for drug-delivery and biotechnological applications
Full text linkThe work presented in this thesis aimed to set out the basis for the rational design of innovative protein-based carriers for drug-delivery and biotechnological applications. In this context, ferritin stood out as promising protein system due to its remarkable characteristics. Ferritins are versatile biocompatible proteins scaffolds that display a cage-like structure that provides shielding of the cavity’s content from harsh external conditions, and are amenable to modifications in a relatively straightforward manner.
Previously published information noted that the proteic cage of ferritins presents an unexpected degree of plasticity in that it can undergo significant structural rearrangements and thus trap small molecules within the internal cavity, a process referred to as “encapsulation”. However the assembled state of ferritin’s cage has always been seen as an impermeable structure, in which the communication between the internal cavity and the exterior is uniquely governed by the gating effect of the channels located at the threefold symmetry axes. In order to clarify the process of molecule confinement within ferritin the internal cavity, a critical analysis of the process of ligand entry/release through the protein matrices of ferritins of different origin was carried. Thus the kinetics of the disulfide bond formation between DTNB and engineered cysteines at selected positions were followed. Kinetics were found to be in the order of tens of seconds, a time frame likely to reflect the slow crossing of the protein matrix.The obtained data indicates that the protein matrix does not provide a significant barrier against bulky ligands such as DTNB, which, due to its dimensions (8-10 Å) and its net negative charge was thought unlinke to cross the protein shell. Within this vision, the technological effort of protein engineering for payload delivery may be most conveniently addressed to modification of the properties of the surface of the internal cavity rather than to possible rearrangements of the threefold channels.
In an effort to develop versatile ferritin-based drug-delivery systems, archaeal ferritins appeared particularly promising as scaffolds. These proteins displays unique assembly properties and extreme thermodynamic stability, however lack the cell recognition properties of human ferritin. Thus a chimeric protein was designed in which the relevant recognition sequence of human ferritin was grafted into the corresponding sequence into archaeal ferritin surface exposed regions in order to confer specific recognition of human epitopes while keeping the unique salt-dependent assembly reaction. The construct structure was determined by X-ray crystallography and successfully shown to be actively uptaken via the Transferrin Receptor 1, a receptor known to be overexpressed in cancer cells. With the aim of improving current encapsulation methods the assembly properties of the novel archaeal-human chimeric ferritin nanocarrier were investigated and the effect of divalent cation investigated. Data demonstrated that physiological Mg2+ concentrations are sufficient to promote full assembly and that assembly takes place in a highly cooperative and fast manner, driven mostly by hydrophobic forces. However, at present, the effect of divalent cations has not been translated into a model of assembly mechanism, though, taken together, data indicates that subunit oligomerization may possibly follow an analogous mechanism as identified for cation-induced assembly of viral capsids. The understanding of the major forces governing the assembly provides key elements for the development of strategies for efficient encapsulation/ release of probes in a controlled way.
On a different approach, the project aimed to exploit the versatility of ferritins for bioimaging applications by inserting an extra functional segment per monomer for binding of luminescent lanthanides, within mouse H ferritin’s cavity. This extra segment possesses one high affinity Terbium binding site provided by six coordinating aminoacid side chains and a tryptophan residue in its close proximity for FRET sensitization. Accordingly, the construct demonstrated lanthanide fluorescence detectable in the pM concentration range and demonstrated to be actively uptaken by selected tumor cell lines by confocal microscopy and FACS analysis of their FITC derivatives. Crystallographic data shown that introduction segment did not disrupt the cage assembly, and the presence of a total of 56 Tb(III) atoms per 24mer. These systems could be used for advanced cell imaging applications, merging the recognition capabilities of ferritins with the notable properties of lanthanide-based fluorescence
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