1,721,403 research outputs found
Cap. 6 - Nozioni di Idraulica dei sistemi di condotte in pressione
No full textVengono descritte le equazioni, i metodi di risoluzione per le reti magliate di distribuzione idrica con accenno ai programmi di calcolo oggi disponibili sul mercato
Ian T. Benson, Michael Quinlan e Keith Thompson, Religious Freedom in Australia – A new Terra nullius, Shepherd Street Press, Sydney, 2019, pp. 1-370.
No full textIl volume offre un interessante e attuale spaccato giuridico, sociologico e culturale sulla regolamentazione del diritto di libertà religiosa in Australia, consentendo una riflessione sulle principali problematiche concernenti la tutela di tale fondamentale diritto in questa parte dell’Oceania.
Il libro, formato da una raccolta di scritti di autori vari, è strutturalmente suddiviso in tre distinte sezioni ottimamente collegate tra di loro dalla comune matrice strutturale costituita dall’intenzione di fornire la “big picture” delle garanzie normative e politiche della “religious liberty” in Australia
Study of pathogenetic molecular mechanisms and new therapeutic approaches for the treatment of Inflammatory Bowel Disease
Full text linkInflammatory bowel diseases (IBDs), resulting from the interaction between genetic and environmental factors which influence the immune responses, are mainly divided into ulcerative colitis (UC) and Crohn’s disease (CD). New studies have shown that IBD is the most common chronic inflammatory disease worldwide, affecting millions of people mainly in industrialized countries.
The number of people with IBD is increasing rapidly, thus, researchers are trying to identify new mechanisms underlying its pathogenesis and find out new treatments to cure the disease as well as to improve the general health and the quality of life of patients.
High-mobility group box 1 (HMGB1) protein, a nuclear non-histone DNA-binding protein, is released into the extracellular milieu and mediates inflammatory responses contributing to the pathogenesis of IBD.
Treatments based on antagonists specifically targeting extracellular HMGB1 have generated encouraging results in a wide number of experimental models of infectious and sterile inflammation. Interestingly, since the current therapeutic approaches for the management of IBD include drugs (immunosuppressors, steroids) and biological treatments that are often associated with adverse health consequences, the use of natural products is gaining worldwide attention.
Accordingly, the whole purpose of this study is to explore novel strategies for limiting the inflammatory potential of HMGB1. More specifically, we aimed at:
1) to assess the ability of the dipotassium glycyrrhizate (DPG), a salt of the glycoconjugated triterpene glycyrrhizin, that has been shown to inhibit the extracellular HMGB1, to reduce intestinal inflammation and improves the mucosal healing;
2) to investigate the interaction between HMGB1 and Poly (ADP-ribose) polymerase 1 (PARP1), a protein recently involved in the regulation of HMGB1 release, and explore the role of PARP1 as a novel molecular target to control gut inflammation.
The results and conclusion of the first point will be presented attaching the published original paper to the thesis (Stronati L, Palone F, Negroni A, Colantoni E, Mancuso AB, Cucchiara S, Cesi V, Isoldi S, Vitali R. Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions. Front Immunol. 2019 Apr 26;10:939).
The results of the second point will be presented and discussed in this thesis.
Briefly, to induce a severe colitis, dextran sodium sulphate (DSS) was used in C57BL/6 WT or PARP1−/− mice. Undifferentiated and differentiated colonoid cultures of intestinal stem cells harvested from biopsies of UC patients were treated with cytomix (TNF + IFN) to induce inflammation.
Results show that PARP1−/− mice exhibit a less severe colitis compared to WT mice, as evidenced by the reduction of HMGB1 in the serum and stool samples. 3D colonoid cultures exposed to cytomix show increased levels of IL-1, IL-8, TNF and DUOXA2 as well as extracellular HMGB1. Interestingly, PARP1 specific inhibitor, PJ34, decreases the release of HMGB1 in undifferentiated as well as differentiated colonoids.
In conclusion these data demonstrate that: 1) PARP1 and HMGB1 are closely related; 2) PARP1 contributes to improve inflammation by promoting the release of extracellular HMGB1; 3) inhibition of PARP1 could represent a promising therapeutic approach to control gut inflammation
"Governo della Chiesa e Curia Romana. Tra riformismo e tradizione"
No full textCome prospettato dai curatori nella fase preparatoria del convegno nazionale,
tenutosi a Trapani dall’1 al 2 dicembre 2022 per iniziativa della cattedra
di diritto canonico ed ecclesiastico del Dipartimento di giurisprudenza dell’Università
degli Studi di Palermo, la scelta del tema “Curia Romana e Governo
della Chiesa. Tra riformismo e tradizione” appare di indubbia rilevanza alla
luce della recente promulgazione della Costituzione apostolica “Praedicate
evangelium”, che porta a termine – a distanza di oltre un trentennio dall’ultimo
intervento di riordino – una riforma complessiva degli organismi integranti
il governo centrale della Chiesa cattolica
Sistemi attivi di prevenzione degli effetti delle radiazioni spaziali nel microsatellite UNISAT
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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