2,051 research outputs found
De procuratoribus eorumque officio
No full textquam ... pro summis in utroque iure honoribus & privilegiis doctoralibus rite legitimeque consequendis, solenni eruditorum censurae subiicit Ioh. Henricus Fels, Lindaviensis. Die 21. Septembris, A.O.R. M DCLXXXIII. Loco horisque consuetisDiss. iur. Basel, 168
Photograph - Fels, R. M.
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/283780Fels, R. M.286650
Item: [2003.0003.00758] "Photograph - Fels, R. M.
Mutagenic response of Ames strains cured of their inducible Fels 1 and Fels 2 prophages
No full textAmes strain TA100 was cured of its Fels 1 and Fels 2 prophages to yield the corresponding nonlysogenic derivative designated TAQ100. The two monolysogenic strains corresponding to TA100 lysogenic for Fels 1 (TAQ100F1) and for Fels 2 (TAQ100F2) were also isolated. In addition, the equivalent strains lacking pKM101 and designated TAQ1535, TAQ1535F1, and TAQ1535F2 were obtained. Ames strains TA98 and TA1538 are lysogenic for Fels 2 and were observed by colony hybridization to contain cryptic Fels 1 DNA sequences. Strains corresponding to TA98 and TA1538 cured of Fels 2 were isolated and designated TAQ98F1d and TAQ1538F1d, respectively. Fels 1 grew poorly on Fels 1-cured strains, and Fels 2 grew not at all on Fels 2-cured strains. The cured strains had therefore to be identified as such by their failure to react in colony hybridization with 32P-labeled probes of Fels 1 and/or Fels 2 DNA. The specificity of the labeled probes was confirmed with the aid of the nonlysogenic Salmonella typhimurium strain Q1 and its two monolysogenic derivatives Q1 (Fels 1) and Q1 (Fels 2). The cured strains were found to respond in the same manner as did the standard Ames strains to a variety of well-known mutagens, including aflatoxin B1, 7, 12-dimethylbenz(a)anthracene, daunorubicin, 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, and beta-naphthylamine. Also, mitomycin C, bleomycin, and diethylstilbestrol were nonmutagenic to TAQ100 and TAQ98F1d as they are to TA100 and TA98. Since the Fels prophages are inducible by aflatoxin B1, by daunorubicin, and by other agents, it seems that mutagenesis and Fels prophage induction occur in separate subpopulations of cells; this situation had previously been reported to occur for mutagenesis and prophage lambda induction in Escherichia coli. In any case, the Fels prophages appear to have no major influence on the mutagenic response of the Ames strains
Curing and induction of the Fels 1 and Fels 2 prophages in the Ames mutagen tester strains of Salmonella typhimurium
No full textA method is described for curing the Ames Salmonella mutagen tester strains of their Fels 1 and Fels 2 prophages with the aid of the antitumor drug daunorubicin. Non-lysogenic derivatives corresponding to TA100 and TA1535 were isolated and designated TAQ100 and TAQ1535 respectively. In addition, the Fels 1 monolysogens TAQ100F1 and TAQ1535F1, as well as the Fels 2 monolysogens TAQ100F2 and TAQ1535F2, were obtained. Finally, strains corresponding to TA98 and TA1538 cured of Fels 2, but retaining a cryptic Fels 1 (F1d) prophage were isolated and designated TAQ98F1d and TAQ1538F1d respectively. The various cured derivatives were identified by colony hybridization with 32P-labeled probes of Fels 1 and Fels 2 DNA. Southern blot hybridizations confirmed that phage-specific Fels DNA sequences were missing from the cured strains. The Fels 2-cured strains were resistant to Fels 2, but Fels 1 grew, albeit poorly, on the Fels 1-cured strains. Strains TAQ100F1, TAQ1535F1, TAQ100F2 and TAQ1535F2 were used in prophage induction assays, in the presence of rat-liver extract where necessary. Daunorubicin, bleomycin, mitomycin C, aflatoxin B1, 2-amino-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2) were found to induce Fels 1 and/or Fels 2 in at least one of these strains. The induction of the Fels prophages in the TAQ monolysogens may provide a useful complement to the Ames test for the detection of DNA-damaging agents and potential carcinogens
Disputatio inauguralis medica de palpitatione cordis
No full textquam ... pro summis in medicina honoribus et privilegiis doctoralibus solenniter consequendis publico eruditorum examini submittit. Ad diem ... Iun. anno M. DC. XCIV. Iohann. Ulricus Felsius, Lindavia-Acronianus.Druckjahr nach dem Datum der DissertationDatum auf Titelblatt hs. ergänzt: Ad diem 2. Iun.Enth. 50 ThesenDiss. med. Basel, 169
Modelling epidemiological and economic consequences of bovine respiratory disease in dairy heifers
No full textBovine respiratory disease (BRD) is an important health problem in dairy heifers. BRD causes considerable losses, particularly on farms that experience high levels of the disease. However, an exact quantification of the economic losses due to BRD was not available yet. Despite this lack of economic insight, dairy farmers have to make decisions with regard to prevention of the disease. To make these decisions as economically sound as possible, more accurate insight is necessary into the economic consequences of BRD on the individual dairy farm.The main objective of the research project described in this thesis was to obtain insight into the on-farm economic consequences of BRD in dairy heifers by means of a PC-based simulation model. The second objective was to collect information on the epidemiological consequences of the disease indispensable for model input.The research started with a literature review aimed at obtaining the necessary qualitative and quantitative information on both the effects of BRD on the productivity of dairy heifers and risk factors of the disease. Because relevant literature turned out to be scarce, a formal expert judgement study was held to obtain additional data on the(se) variables of interest.As a next step, a simulation model was developed that calculates the economic losses due to BRD in dairy heifers for individual dairy farm conditions in the Netherlands. Following the results of the expert judgement study, the model distinguishes between two BRD types, being calf pneumonia and a seasonal BRD outbreak.Model calculations showed that for most dairy farms in the Netherlands the economic losses due to BRD will be relatively small: around 1 % of the farm's net return to labour and management for average situations, increasing up to 3-4 % at worst. For individual farms that experience high levels of BRD, the associated losses can be as high as 10-15 % of the farm's net return to labour and management, up to 25 % for large farms. Besides for calculation of the economic losses due to BRD, the model showed also to be useful for evaluation of the on-farm cost-effectiveness of prevention of the disease. Moreover, the model is flexible and user-friendly, hence, can be used as a tool to support decision-making in dairy practice.</p
Beam diagnostics challenges for future FELs
No full textDesigns are being developed to produce diffraction-limited sources based on storage-ring free-electron lasers (FELs) for the VUV and soft x-ray regime and linac-driven FELs in the few {Angstrom} regime. The requirements on the beam quality in transverse emittance (rms, normalized) of 1-2 {pi} mm mrad, bunch length (1 ps to 100 fs), and peak current (1 to 5 kA) result in new demands on the diagnostics. The diagnostics challenges include spatial resolution (1-10 {mu}m), temporal resolution (<100 fs), and single-pulse position measurements ({approximately}1 {mu}m). Examples of recent submicropulse (slice) work are cited as well as concepts based on spontaneous emission radiation (SER). The nonintercepting aspects of some of these diagnostics should also be applicable to high-power FELs
Photograph - Law, Dr Philip (right), Cheryl McKinna and Dr R. M. Fels
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/284332Law, Dr Philip (right), Cheryl McKinna and Dr R. M. Fels308878
Item: [2003.0003.01310] "Photograph - Law, Dr Philip (right), Cheryl McKinna and Dr R. M. Fels
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