46 research outputs found
CHROMOSOMAL LOCUS 19P13 AS POTENTIAL HOTSPOT FOR ABERRANT GENE EXPRESSION IN RELAPSED PAEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA.
No full textno abstrac
Metabolic profiling of faecal sterol excretion in a patient affected of lathosterolosis using gc/ms.
No full textIncreased Carotid Intima-Media Thickness In Insulin Resistant Obese Children.
No full textDigestive And Liver Disease. 2008;40:41-4
A metabonomic analysis of total sterol profiles in blood cell membranes of children receiving lipid emulsions: a possible role of phytosterols of parenteral nutrition associated liver disease.
No full textA metabonomic analysis of total sterol profiles in blood cell membranes of children receiving lipid emulsions: a possible role of phytosterols of parenteral nutrition associated liver disease.
No full textProfilo metabolico degli steroli fecali in una paziente affetta da latosterolosi mediane GC/MS.
No full textProfilo metabolico degli steroli fecali in una paziente affetta da latosterolosi mediane GC/MS.
No full textSterols profiling in red blood cell membranes and plasma of newborns receiving total parenteral nutrition.
No full textBackground and Objectives: Total parenteral nutrition (TPN)
is a lifesaving therapy in children with intestinal failure,
frequently complicated by liver dysfunction. Plant sterols
(phytosterols) of lipid emulsions have been supposed to
contribute to cholestasis in TPN-treated children. The present
study aimed to evaluate the plasma and red blood cell
membrane (RBCM) phytosterol levels in newborns after a
short period of TPN.
Patients and Methods: Phytosterols, cholesterol, and other
sterol levels were quantified by gas chromatography-mass
spectrometry in 15 healthy control infants, 22 patients after
TPN, and 11 patients before TPN. Sterols of lipid emulsions
were quantified.
Results: Plasma and RBCM phytosterol levels were,
respectively, on average 56mmol/L and 83mmol/g per
protein in patients after TPN, 13mmol/L and 15mmol/g per
protein in patients before TPN, and 9mmol/L and 13mmoL/g
per protein in control infants (P<0.05 for differences). The
days of TPN and the total amount of infused lipids correlated
significantly with RBCM phytosterol (P<0.05); correlations
for plasma were positive but not significant. No correlation was
observed with plasma bilirubin, g-glutamyltransferase, or
alanine transaminase.
Conclusions: Plasma and RBCM phytosterols increase
significantly in newborns after a short period of TPN. Higher
phytosterol levels were observed in some patients that could
have been due to their individual variability in phytosterol
metabolism and/or clearance. A greater accumulation of
phytosterols in membranes may induce TPN-related
cholestasis
