1,721,060 research outputs found
Transpulmonary pressure during high-frequency oscillation ventilation: Is it the culprit?
Full text linkFluids in ARDS : from onset through recovery
No full textEarly acute respiratory distress syndrome (ARDS) is characterized by protein-rich inflammatory lung edema often associated with a hydrostatic component. Mechanical ventilation with positive intrathoracic pressure further induces salt and water retention, while impairing the pathways designed for edema clearance. In this framework, we will review the recent findings on fluid strategy and edema clearance in ARDS
Pulmonary computed tomography and adult respiratory distress syndrome
No full textComputed tomography has completely changed the views and interpretation of ARDS, opening a new era in our understanding of the physiological, pathological and clinical aspects of this syndrome. In this brief review we will emphasize the most relevant new knowledge achieved using CT scanning and we will briefly discuss its clinical use in ARDS patients
Assessing gas exchange in acute lung injury/acute respiratory distress syndrome : diagnostic techniques and prognostic relevance
No full textPurpose of review
To provide the most recent insights on the assessment of gas exchange in acute lung
injury.
Recent findings
Central venous blood may be used as a surrogate of arterial blood to assess carbon
dioxide tension and acid–base status. In contrast arterial oxygenation cannot be
estimated with confidence from venous blood. However, the use of venous blood
associated with pulse oximetry may provide the SvO2 which is useful for monitoring and
targeting the resuscitation therapy. Impaired CO2 clearance and increased dead space
have been confirmed as useful prognostic indices of structural lung damage and
mortality in acute respiratory failure. A simplified technique based on multiple inert gas
technique has been described to assess ventilation–perfusion mismatch while a new
analysis of pulse oximetry has been suggested to detect lung opening and closing.
Finally, new insight has been provided on the relationship between lung anatomy, as
detected by computed tomography, oxygenation and CO2 clearance.
Summary
Although oxygenation assessment is of primary importance during respiratory lung
injury, dead space and CO2 retention are more strictly associated with outcome. The
association of central venous blood analysis and pulse oximetry may provide more
information than arterial blood alone
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Recruitability, recruitment, and tidal volume interactions: is biologically variable ventilation a possible answer?
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