1,720,973 research outputs found
Clinical validation of integrated diagnosis in low-grade glioma (LGG)
No full textThe importance of adding molecular data to histology for better stratifying tumor patients has been recently proposed by WHO; an integrated diagnosis has been recommended for routine pathological practice, in which molecular data obtained from the most representative area of the tumor are associated to histological appearance. We have evaluated the impact of the integrated diagnosis classification on LGGs progression in a series of tumors operated in our center. Inclusion criteria were a) histological diagnosis of grade II diffuse gliomas; b) full radiological, surgical and clinical data on admission and at follow up (mean 6.3 years (5–9 years), to evaluate extent of resection (EOR), seizure control, eventual treatment and PFS; c) presence of IDH1 mutation. 242 patients fulfilled the criteria and were reevaluated according to integrated diagnosis. Tumors initially classified as 101 oligodendrogliomas, 76 astrocytomas, and 65 oligoastrocytomas, were reclassified accordingly as 167 grade II oligodendrogliomas and 75 astrocytomas. Tumors were then further stratified according to EOR and seizure control in low (79,3%) and high (20,7%) risk. The impact of tumor reclassification was evaluated in term of PFS, looking at the rate of recurrence, divided as early (within 3 years from surgery) and late (after 5 years), and rate of malignant transformation. When tumors were classified according to traditional histological subgroups (oligodendrogliomas, astrocytomas, mixed gliomas) PFS of oligodedrogliomas was better than that of astrocytomas (5.3 vs 4.2 yrs) but without reaching statistical difference. When classified according to integrated diagnosis, some flaws appeared as showed by the occurrence of early recurrence (5,9%) and malignant transformation (5,1%) even in tumors with the best clinical (GTR) and molecular prognostic factors (IDH1 mut, codelation). True astrocytoma (IDH1 mut, ATRX loss, no codel) did worst then true oligodendroglioma (26,8% early recurrence and 10,7% malignant transformation, in low risk).These data indicate that integrated diagnosis a) better stratified patients than traditional histology, b) still does not fully describe the biological behavior of the tumor. Additional biological markers may be also important for additionally stratify LGGs
Long-Term Follow-Up of Patients with Metastatic Epidural Spinal Cord Compression from Breast Cancer Treated with Surgery Followed by Radiotherapy
No full textObjective To evaluate role of surgery plus radiotherapy (RT) in patients with metastatic epidural spinal cord compression from breast cancer with a follow-up >10 years. Methods The study included 23 patients treated between 2004 and 2008. Surgical treatment was performed in patients with good performance status, limited metastatic disease, and progressive neurologic deficit and/or intractable pain. RT was performed delivering a median total dose of 30 Gy in 10 fractions. Clinical outcome was evaluated using the modified visual analog scale for pain, Frankel grade for neurologic deficit, and magnetic resonance imaging before and after treatments and every 3 months thereafter. Results Minimal resection was performed in 17.4% of patients, curettage in 47.8%, and total tumorectomy in 34.8%, followed by RT in 78.3%. Pain remission was obtained in 98% of patients, and recovery of neurologic function was obtained in 92.9%. Median follow-up time was 153 months (range, 128â209 months). No relapse at site of treatments occurred. Median overall survival time was 47 months (95% confidence interval 33â114 months), and 2-, 5-, and 10-year overall survival rates were 81% (±8.6%), 42.9% (±10.8%), and 28.6% (±9.9%). On univariate analysis, performance status, type of surgical resection, breast cancer phenotype, and presence of other bone metastases were recorded as influencing survival; the last-mentioned was also confirmed in multivariate analysis. Conclusions Surgery plus RT is a safe and feasible treatment with limited morbidity. In selected patients with good performance status, positive hormonal receptors, and limited metastatic disease, surgical intervention should be strongly considered early on
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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