478 research outputs found
I Rapporti di lavoro nella Pubblica Amministrazione nel contesto del Dialogo Sociale Europeo
No full textL’articolo si occupa dei limiti alla libera circolazione dei lavoratori, dovuti alla partecipazione ai pubblici poteri da parte dei funzionari pubblici
SENP1 activity sustains cancer stem cell in hypoxic HCC
No full textHepatocellular carcinoma (HCC) represents the fifth most common cancer and the third leading cause of cancer mortality worldwide, with a minority of patients surviving at 5 years from diagnosis, despite treatment. HCC usually develops in conditions of chronic liver disease (CLD), mostly on the background of a cirrhotic liver, with liver transplantation at present being the only treatment strategy to cure both HCC and the specific CLD
A multi-regional input-output model with elastic trade coefficients for the simulation of freight transport demand in Italy
No full textA multi-regional input-output model with elastic trade coefficients for the simulation of freight transport demand in Italy
No full textLaparoscopic fundoplication for gastroesophageal reflux disease
No full textGastroesophageal reflux disease (GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor (PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total (360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior (Toupet) fundoplication, and the anterior (Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard
Study of Absorbance and Fluorescence Properties of Laccase and Catechol Solutions in the UV Range †
No full textLaccase is an enzyme belonging to the oxidoreductase class and has copper atoms in the catalytic centre. The catalytic property of this enzyme consists of the enzymatic oxidation of the phenolic compounds, in the corresponding quinones, with the concomitant reduction of molecular oxygen to water. There is growing interest in developing innovative sensing methods for detecting phenolic substrates, such as catechol. Preliminary absorption and fluorescence measurements were carried out in the UV-visible range to evaluate the possibility of using the variations produced in the spectra of laccase and/or catechol to monitor the presence of this substrate. The absorption and fluorescence emission increase upon UV excitation was detected. By monitoring the time course of the fluorescence signal, an evident increase in the signal detected in the UV range is observed until a saturation level is reached. The observed variations in the spectra, in the presence of the catechol, are discussed also in terms of the interactions between the enzyme and the phenolic compound. The results are very promising for the design of new optical detection methods for polyphenol pollutants
Italian Studies on Quality of Life: an interdisciplinary overview
No full textThis volume provides an overview of the ways the Italian school of quality of life studies addresses well-being and quality of life, from both a substantive and a methodological point of view. It discusses various topics such as those of equitable and sustainable wellbeing, lifestyles, the organization of economy and welfare, as well as aspects related to the measurement of quality of life in small towns, institutional transparency and corruption prevention indicators. Chapters presented in this volume are drawn from papers presented at the conferences of the Italian Association for Quality of Life Studies (AIQUAV) held in Florence, Italy, in 2015 and 2016. The volume is organised into three parts. The first part is devoted to methods and indicators for research on quality of life, the second part to social sustainability, lifestyles, cultural aspects and local applications, and the third to economy, welfare and quality of life. The volume hosts contributions that are interdisciplinary in scope and mirror the complexity of the globalized world
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