370 research outputs found
Correction to: Nutrition behaviour and compliance with the Mediterranean diet pyramid recommendations: an Italian survey‐based study
No full textThe article “Nutrition behaviour and compliance with the Mediterranean diet pyramid recommendations: an Italian survey‐based study”, written by “Renata Bracale, Concetta M. Vaccaro, Vittoria Coletta, Claudio Cricelli, Francesco Carlo Gamaleri, Fabio Parazzini and Michele Carruba” was originally published electronically on the publisher’s internet portal on 8th November 2019 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 23rd December 2019 to © The Author(s) 2019 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https ://creat iveco mmons .org/licen ses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The original article has been corrected
Nitric oxide and mitochondrial biogenesis
No full textThe characteristic structural organization of mitochondria is the product of synthesis of macromolecules within the mitochondria together with the import of proteins and lipids synthesized outside the organelle. Synthetic and import processes are required for mitochondrial proliferation and might also facilitate the growth of pre-existing mitochondria. Recent evidence indicates that these events are regulated in a complex way by several agonists and environmental conditions, through activation of specific signaling pathways and transcription factors. A newly discovered role of this organelle in retrograde intracellular signaling back to the nucleus has also emerged. This is likely to have far-reaching implications in development, aging, disease and environmental adaptation. Generation of nitric oxide (NO) appears to be an important player in these processes, possibly acting as a unifying molecular switch to trigger the whole mitochondrial biogenesis process. High levels of NO acutely inhibit cell respiration by binding to cytochrome c oxidase. Conversely, chronic, smaller increases in NO levels stimulate mitochondrial biogenesis in diverse cell types. NO-induced mitochondrial biogenesis seems to be linked to proliferation and differentiation of normal and tumor cells, as well as in agin
Virtual Reality (VR) in Special Education: Cooking Food App to Improve Manual Skills and Cognitive Training for SEN Students Using UDL and ICF Approaches
No full textVirtual reality (VR) enters educational processes today as a tool capable of promoting immersive learning experiences and facilitating the engagement and participation of all students, including those with Special Educational Needs (SEN). This paper aims to present a case study concerning the use of VR to improve manual skills and promote immersive and enjoyable cognitive training for students with disabilities. A VR cooking food preparation app is introduced to illustrate how VR serves as a tool for skill training on one hand and as a genuine digital learning environment on the other. In addition to presenting the technical features of the app, the International Classification of Functioning (ICF) approach by the World Health Organization (WHO) will be discussed. This approach is useful for identifying the best strategies to promote learning for students with cognitive disabilities who participated in this case study. Furthermore, the perspective of universal learning design (UDL), also known as Universal Design for Learning (UDL) by CAST, will be explored to guide teachers and trainers in designing digital and innovative learning activities that can accommodate all students
Sustained turbidity currents : evidence from the Pliocene Periadriatic foredeep (Cellino Basin, Central Italy)
No full textThe aim of this work is to investigate the nature of the numerous, very thick deep-water sheet-sandstones that dominate the lower portion of the Cellino Formation (Central Italy).
The studied turbidite system (about 2,500 m thick) represents the Lower Pliocene turbiditic filling of the outer Abruzzo sector of the Periadriatic foredeep. The foredeep was affected by compressional deformation linked to the overall migration of the chain-foredeep system toward the east. Tectonic activity was mostly coeval with the sedimentation and propagated towards the foreland; thrusting became progressively younger from W to E. The Cellino Basin has been intensely explored, being the site of hydrocarbon-bearing sands.
Very thick beds can be distinctively resolved in the well logs and correlated to the measured sedimentary sections on outcrop. Based on well log correlation, tens of individual beds up to 23 m thick have been traced along the axis of the basin over distance of at least 150 km and, perpendicularly to the basin, over distance of 30-40 km (Carruba et al., 2006). Palaeocurrent data taken from basal flute structures indicates southerly-directed flows, parallel to the depocentral axis of the basin. The thickest beds show a basin-wide extension, onlapping the basin margins without significant thickness variation. The Cellino Formation is mostly buried and crops out in a narrow belt a few kilometers west of the Cellino gas field.
The internal organization of the studied megabeds provides evidence for occurrence of long-lived flows and suggests deposition by gradual aggradation from sustained currents (sustained turbidity current, Kneller & Branney, 1995).
Assuming a quasi-steady flow scenario we can explain the nature of the numerous very thick megabeds within the Cellino Fm considering that the determining factors of the thickness of the studied deposits are the confinement of the basin and the rate and the duration of deposition, which may proceed as long as the current maintains a flux of grains towards the site of deposition.
The origin of these large-volume turbidity currents and their high rate of occurrence can be related to an interaction of many factors and external controls, which are typical of the ancient foredeep basins (Mutti et al., 2003).
The depocenter migration of the Periadratic Foredeep caused the accumulation of thick sedimentary bodies, which developed progressively within the depositional axes. Since the collisional margins were convergent, there was longitudinal migration of depocenters. Our data suggest that the studied megabeds could be originated from catastrophic floods and sediment failures during relative falling- and low-stand stage of sea-level forced by dramatic tectonic uplift of basin margins and turbidity systems already deposited in the northern areas
Additional Support and Mediated Learning in Inclusive Education in Europe
No full textThe present research has been realized within the ASuMIE Project funded by Erasmus + KA2. The book is the result of a comparative analysis about Inclusive Education in seven different countries: Italy, Belgium, Bulgaria, Czech Republic, Slovenia, Norway and Portugal. Collected data has been analyzed in the light of national and international literature. The principal topics are support systems for disabled students, mediated education and IEP/life plan project for disabled people and their families
Google Earth in VR, for Students with Special Needs
No full textVirtual Reality (VR) is one of the major technology trends right now and will increase much more in the future. This technology promotes a new way of interaction, communication, and productivity. This paper aims to allow students with special needs to work and interact with Google Earth using VR. The theoretical framework used, the International Classification of Functioning, Disability, and Health (ICF) perspective and checklists, allows us to identify the best way to propose an interactive and funny learning process for students with Special Educational Needs (SEN). By means of ICF, the definition of the proper technological tools and of the main steps in which the learning process can be divided is possible. This approach, indeed, leads to the translation of cognitive tasks that can result too complex for students with cognitive fragilities into concrete experiences more easily to do for all, promoting inclusion and equity in our modern digital society. In the present work, the inclusive VR-based technology is tested on a group of 10 students with SEN in Google Earth environment, and the final outcomes in terms of system usability are presented
Dopamine inhibition of neurotensin-induced increase in Ca2+ influx into rat pituitary cells.
No full textIn this paper, we report that the intracellular mechanism by which neurotensin stimulates prolactin release involves an increase in Ca2+ uptake by pituitary cells rather than an effect on adenylate cyclase system. In addition, dopamine can prevent neurotensin-induced calcium influx by interacting with dopamine D2-receptors which appear to be completely independent of the adenylate cyclase moiety but are coupled to calcium channels
Extended Reality for Special Educational Needs: From the Design Process to Real Products Through 3D Printing
No full textExtended Reality (ER) stands out as one of the major technology trends currently, with expectations of even further growth in the near future. The primary objective of this paper is to develop an ER application for the Sharebot One and Sharebot Next Generation 3D Printers, specifically designed to assist students with special needs. The application follows an inclusive design perspective based on the International Classification of Functioning, Disability, and Health (ICF) by the World Health Organization (WHO), enabling students to work and interact with the machine safely. To achieve this goal, three configurations have been developed and tested: a desktop version running on a PC, an Android tablet-based version, and a solution optimized for the Microsoft HoloLens device
Linguistic and intercultural mediation: reflection perspectives
No full textL'articolo esplora il contributo della pedagogia interculturale nella mediazione linguistica per sviluppare interazioni che non siano solo linguistiche, ma efficaci dal punto di vista interculturale
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