332 research outputs found
Parsing with Polymorphic Categorial Grammars
No full textIn this paper we investigate the use of polymorphic categorial
grammars as a model for parsing natural language. We will show that,
despite the undecidability of the general model, a subclass of polymorphic
categorial grammars, which we call linear, is mildly context-sensitive and
we propose a polynomial parsing algorithm for these grammars
Characterization of GSTM3 polymorphism by Real-Time PCR with LightCycler. Mozzoni P, De Palma G, Scotti E, Capelletti M, Mutti A.
No full textPolymorphic Categorial Grammars: expressivity and computational properties
No full textWe investigate the use of polymorphic categorial grammars as a model for parsing natural language. We will show that, despite the undecidability of the general model, a subclass of polymorphic categorial grammars, which we call linear, is mildly context-sensitive and we propose a polynomial parsing algorithm for them. An interesting aspect of the resulting system is the absence of spurious ambiguity
MET and ALK as targets for the treatment of NSCLC
No full textCell proliferation, survival, differentiation, migration and metabolism are some of the fundamental cellular processes tightly controlled by the activity of tyrosine-kinase receptors (RTKs). The aberrant signaling of RTKs contributes to cancer growth and survival and has become important target for therapeutic approaches. Well-characterized kinase molecular target in lung cancer, in particular in non-small cell lung cancer (NSCLC), is the activated epidermal growth factor receptor (EGFR) pathway. More recently, the oncogenic role of other two tyrosine-kinases, the hepatocyte growth factor receptor (MET) and the anaplastic lymphoma kinase (ALK), has been recognized. Many different therapeutic strategies have been investigated with the goal to inhibit these receptors, subsequent downstream signaling cascades and arrest tumor growth. This review will discuss the MET and ALK pathways, the different strategies of their inhibition and the potential approaches to overcome acquired resistance to kinase inhibitors in these two genes. © 2014 Bentham Science Publishers
The middle house or the middle floor: Bisecting horizontal and vertical mental number lines in neglect
No full textAbstract
This study explores the processing of mental number lines and physical lines in five patients with left unilateral neglect. Three tasks were used: mental number bisection (‘report the middle number between two numbers’), physical line bisection (‘mark the middle of a line’), and a landmark task (‘is the mark on the line to the left/right or higher/lower than the middle of the line?’). We manipulated the number line orientation purely by task instruction: neglect patients were told that the number-pairs represented either houses on a street (horizontal condition) or floors in a building (vertical condition). We also manipulated physical line orientation for comparison. All five neglect patients showed a rightward bias for horizontally oriented physical and number lines (e.g. saying ‘five’ is the middle house number between ‘two’ and ‘six’). Only three of these patients also showed an upward bias for vertically oriented number lines. The remaining two patients did not show any bias in processing vertical lines. Our results suggest that: (1) horizontal and vertical neglect can associate or dissociate among different patients; (2) bisecting number lines operates on internal horizontal and vertical representations possibly analogous to horizontal and vertical physical lines; (3) at least partially independent mechanisms may be involved in processing horizontal and vertical number lines
High resolution absorption spectroscopy of rare earth doped insulating materials: BaY2F8 and YAl3(BO3)4 single crystals and sol-gel silica glasses
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