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Elminti : una nuova e inaspettata frontiera terapeutica per le malattie infiammatorie intestinali
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Le malattie infiammatorie croniche intestinali
No full textThe inflammatory bowel diseases (IBD), namely Crohn's disease and ulcerative colitis, are uncommon diseases characterized by a relapsing and remitting course. The highest incidence is observed in the Caucasian population living in developed countries. The pathogenesis is still unknown, although the literature suggests that many factors are involved, including infectious, genetic (NOD 2/CARD 15 mutations), immunological and environmental factors. The most common clinical symptoms are diarrhea with ematochezia, abdominal pain anemia and fever. Complications of IBD may be intestinal (toxic megacolon, perforation, strictures and fistulas) and/or extraintestinal (arthritis, dermatological lesions and ocular inflammations). The diagnosis is made by endoscopic and histological evaluation; radiological imaging and ultrasonography also provide significant information for disease management and diagnosis of complications. Treatment is based on 5-ASA products for maintaining remission and corticosteroids for management of relapse., Immunosuppressant agents (AZA; MTX) may be used in the event of steroid dependence/resistance. The new and developing approach is the use of biological drugs, like Infliximab and other anti-TNF-(alpha) drugs. Other new therapies like leucocyte apheresis or autologous stem cell transplantation need to be validated in large population studies
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Prospective randomized comparison of three bowel preparations for elective colonoscopy in patients with inflammatory bowel disease
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