1,976 research outputs found
S. Brakensiek, M. Stolleis, H. Wunder (Hg.): Generationengerechtigkeit? (Jean-Michel Boehler)
No full textTutorial: guidelines for standardized performance tests for electrodes intended for neural interfaces and bioelectronics
No full textImplantable neural interfaces advance the possibilities for neuroscientists to study the brain. They are also promising for use in a multitude of bioelectronic therapies. Electrode technology plays a central role in these developments, as the electrode surfaces form the physical interfaces between technology and the biological targets. Despite this, a common understanding of how electrodes should best be evaluated and compared with respect to their efficiency in recording and stimulation is currently lacking. Without broadly accepted performance tests, it is difficult to rank the many suggestions for electrode materials available in the literature, or to identify where efforts should be focused to advance the field most efficiently. This tutorial critically discusses the most relevant performance tests for characterization of neural interface electrodes and explains their implementation, interpretation and respective limitations. We propose a unified standard to facilitate transparent reporting on electrode performance, promote efficient scientific process and ultimately accelerate translation into clinical practice
The cost of changing physical activity behaviour: Evidence from a "physical activity pathway" in the primary care setting
No full textCopyright @ 2011 Boehler et al.BACKGROUND: The ‘Physical Activity Care Pathway’ (a Pilot for the ‘Let’s Get Moving’ policy) is a systematic approach to integrating physical activity promotion into the primary care setting. It combines several methods reported to support behavioural change, including brief interventions, motivational interviewing, goal setting, providing written resources, and follow-up support. This paper compares costs falling on the UK National Health Service (NHS) of implementing the care pathway using two different recruitment strategies and provides initial insights into the cost of changing physical activity behaviour. METHODS: A combination of a time driven variant of activity based costing, audit data through EMIS and a survey of practice managers provided patient-level cost data for 411 screened individuals. Self reported physical activity data of 70 people completing the care pathway at three month was compared with baseline using a regression based ‘difference in differences’ approach. Deterministic and probabilistic sensitivity analyses in combination with hypothesis testing were used to judge how robust findings are to key assumptions and to assess the uncertainty around estimates of the cost of changing physical activity behaviour. RESULTS: It cost £53 (SD 7.8) per patient completing the PACP in opportunistic centres and £191 (SD 39) at disease register sites. The completer rate was higher in disease register centres (27.3% vs. 16.2%) and the difference in differences in time spent on physical activity was 81.32 (SE 17.16) minutes/week in patients completing the PACP; so that the incremental cost of converting one sedentary adult to an ‘active state’ of 150 minutes of moderate intensity physical activity per week amounts to £ 886.50 in disease register practices, compared to opportunistic screening. CONCLUSIONS: Disease register screening is more costly than opportunistic patient recruitment. However, additional costs come with a higher completion rate and better outcomes in terms of behavioural change in patients completing the care pathway. Further research is needed to rigorously evaluate intervention efficiency and to assess the link between behavioural change and changes in quality adjusted life years (QALYs).This article is available through the Brunel Open Access Publishing Fund
An exposition of Christian doctrine, as taught in the protestant church of the United Brethren : or, Unitas Fratrum /
No full textSignatures of Francis Boehler, 1785 [crossed through] and Constantine Müller. [Ba 105].; Inscription: David Barton, to Susannah (Barton) David, to Joseph H. Kummer. [Ba 108].; Inscription: D.B. Presented by his very worthy friend Hans Christian von Scweidnitz, Bart.; Label of Wm. G. Malin. [Malin 399].; Label of Library of the Congregation of U.B. of the Borough of Bethlehem and Its Vicinity. No. 167 [CongLib 167].; ESTC
Lung transplantation for lymphangioleiomyomatosis: the European experience
No full textBackground:
Lung transplantation has been accepted widely as therapy for end-stage pulmonary lymphangioleiomyomatosis (LAM); however, single-center and national experience is limited due to the rarity of LAM.
Methods:
We report the recent European experience of lung transplantation for LAM. A self-administered questionnaire was distributed to 30 European lung transplant centers to evaluate patients who underwent primary lung transplantation for LAM (1997 to 2007).
Results:
Seventy percent of centers responded to the questionnaire. A total of 61 lung transplants were undertaken in women only, with mean age at transplant 41.3 years (SD 5.1). Centers performed a median of 2 (0 to 9) transplant operations. Severe pleural adhesions were the most common intra-operative complication. Early deaths (N = 6) were due to primary graft or multiple-organ failure or sepsis. Twelve recipients were diagnosed with bronchiolitis obliterans syndrome at a median of 20 months (range 10 to 86 months) post-transplant. LAM-related complications included renal angiomyolipoma and pneumothorax in the native lung. Recurrence of LAM occurred in 4 recipients. As of December 2007, actuarial Kaplan–Meier survival was 79% at 1 year and 73% at 3 years post-transplant.
Conclusions:
Post-transplant outcome for pulmonary LAM in the recent era appears to have improved compared with the previous era. LAM-related complications remain common, but recurrence of LAM in the allograft is rare
Comparison of Glycerophosphate Acyltransferases From Euglena Chloroplasts and Microsomes
No full textThe acylation of sn-glycerol 3-phosphate is a common reaction in the pathways leading to the biosynthesis of glycerol-derived phospholipids, galactolipids, and sulfolipids. Enzymes catalyzing this reaction have been solubilized from Euglena chloroplasts, microsomes, and mitochondria (B. A. Boehler and M. L. Ernst-Fonberg (1976) Arch. Biochem. Biophys. 175, 229-235; L. V. Grobovsky, S. Hershenson, and M. L. Ernst-Fonberg (1979) FEBS Lett. 102, 261-264). Some characteristics of the reactions catalyzed by the acyl-CoA:sn-glycerol-3-phosphate O-acyltransferases (EC 2.3.1.15) solubilized from chloroplasts and microsomes of Euglena have been compared. Although the two enzymes have some common features, including stimulation by bovine serum albumin and phosphatidyl choline and sensitivity to sulfhydryl-binding reagents, they differ in their stabilities and responses to salt and glycerol. They exhibit different acylCoA substrate dependency curves. The proportions of monoacyl sn-glycerol-3-phosphate acyltransferase activity differ in the two solubilized enzyme preparations, and different products are produced by each of the glycerophosphate acyltransferases solubilized from chloroplasts and microsomes, respectively. Neither glycerophosphate acyltransferase will use palmitoyl- or myristoyl-acyl carrier protein (ACP) as a substrate, whereas both use the corresponding CoA esters. Neither is inhibited by ACP, but the enzyme from microsomes is inhibited by CoA
Ackerman, Edwin Hobert (Birth, 1899-10-03)
No full textAddress: 404 Carmalt St.4563/Pg 703/1899/M W/Ger./Cinti, Ohio/(Nee Boehler)/Dr. F.F. Hellmann, Mid.Original record filed in drawer labeled'A-ADAMS'
INNOVATIVE TREATMENT SOLUTIONS FOR SEWAGE SLUDGE RECOVERY ON A FP7 PROJECT ROUTES
No full textROUTES is addressed to assess new routes in wastewater and sludge treatment focusing on three main
objectives:
1. optimization of the sludge quality for agricultural use with the goal to produce a clean and full stabilized
sludge through intensive stabilization processes with attention to a broad spectrum of parameters including micropollutants,
pathogens and their indicators.
2. minimization of the sludge to be disposed by innovative technical solutions based on different approaches,
either on the water or sludge treatment lines;
3. recovery of valuable resources before sludge disposal by producing a liquid fertilizer [(NH4)2SO4],
biopolymers or optimizing methane production by anaerobic treatments.
Technical and economic assessment of the investigated techniques on laboratory and pilot scale were carried
out in a typical benchmarking study. The whole set of data is then provided to the partner involved in environmental
assessment where different impact categories are considered (global warming potential, acidification potential,
eutrophication potential and photochemical ozone creation potential)
The structure of iron under the conditions of the Earth's inner core
No full textThe inferred density of the solid inner core indicates that it is predominantly made of iron. In order to indicates that it is predominantly made of iron. In order to interpret the observed seismic anisotropy and understand the high pressure and temperature behaviour of the core, it is essential to establish the crystal structure of iron under core conditions. On the basis of extrapolated experimental data, a number of candidate structures for the high PIT iron phase have been proposed, namely, body-centred cubic (bcc), body-centred tetragonal (bct), hexagonal close-packed (hcp), double-hexagonal close-packed (dhcp) and an orthorhombically distorted hcp polymorph (Matsui, 1993; Stixrude and Cohen, 1995; Boehler, 1993; Saxena et al., 1996; Andrault et al., 1997). Here we present the results of the first fully ab initio free energy calculations for all of these polymorphs of iron at core pressures and temperatures. Our results show that hcp-Fe is the most stable polymorph of iron under the conditions of the Earth's inner core
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