7,895 research outputs found
Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
No full textThe extracellular amino terminal domain (ATD) of the NR2 subunits differentially controls NMDA receptor activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out patches at pH7.9. NR1/NR2B receptors were found to exhibit modal gating in both forms of recording which was unaffected by ifenprodil. Ifenprodil increased the occupancy of the receptor in long-lived shut conformations hence reducing the open probability of receptor with no change in the mean open time. We found a negative correlation between the open and shut intervals in NR1/NR2B recordings from cell attached patches containing one active channel similar to those previously reported for NR1/NR2A receptors. In order to further understand actions of ifenprodil we fitted the single channel data to previously proposed models for NMDA receptor gating. Log likelihood criteria suggested that a cyclic model containing two uncoupled open states (Schorge et al. 2005) fitted the data better compared to a linear model with sequential open states. Ifenprodil modified multiple gating steps when fitted to an `uncoupled cyclic' model and promoted receptor desensitization. In contrast a single gating step was modified when single channel data was fitted to the `linear' gating model. Our results suggest an allosteric cross talk between the NR1 and NR2 subunits of the NMDA receptors.xiii, 78 page
The Cassandras in Exile: A Study of the Diasporic Sensibility in the Poetry of Meena Alexander, Sujata Bhatt, Chitra Banerjee Divakaruni, Moniza Alvi and Jean Arasanayagam
No full textNot availabl
Implementing data analytics and architectures for next generation wireless communications Advances in wireless technologies and telecommunication (AWTT) book series./ Chintan Bhatt, Neeraj Kumar, Ali Kashif Bashir, Mamoun Alazab.
No full text"Premier Reference Source" -- taken from front cover.Includes bibliographical references and index."This book covers the existing and emerging theoretical and practical challenges in the design, development and implementation of big data algorithms, protocols, architectures, and applications for next-generation wireless communications and their applications in smart cities"--Implementing data analytics and architectures for next generation wireless communications / Chintan Bhatt, Charotar University of Science and Technology, India, Neeraj Kumar, Thapar University, India, Ali Kashif Bashir, Manchester Metropolitan University, United Kingdom, Mamoun Alazab, Charles Darwin University, Australia -- Evaluation of turbo decoder performance through software reference model / Manjunatha N, Jain (Deemed-To-Be-University), India, Raghu N, Jain (Deemed-To-Be-University), India, Kiran B, Jain (Deemed-to-be University), India -- Role of Zigbee protocol in smart home appliances / Sirineni Lakshmi, Aurora's Degree & PG College, Dr. Viswanadham Bulusu, Aurora's Degree & PG College, India, Hari Prasada Rao Javangula, Aurora's Degree & PG College, India.1 online resource (xiii, 227 pages)
Impact of receiver sensitivity on the performance of ad hoc wireless networks
No full textMedium access control (MAC) protocols significantly affect the performance of sensor networks. Little attention, however, has been devoted to the impact of physical layer characteristics on the MAC layer. One of the most important physical layer parameters is the receiver sensitivity. In this paper, we study the impact of receiver sensitivity on the network performance using a recently developed communication-theoretic framework for the analysis of multi-hop ad hoc wireless networks. In particular, we consider a reservation-based MAC protocol scheme, defined as reserve-listen-and-go (RESLIGO) without retransmission, suitable for circuit-switched sensor networks with limited receiver sensitivity. It will be shown that, in order to maximize the transfer of information in the network, the optimal receiver sensitivity depends on the traffic load
sj-docx-1-oss-10.1177_01708406231203295 – Supplemental material for Prefiguring Alternative Organizing: Confronting marginalization through projective cultural adjustment and tempered autonomy
No full textSupplemental material, sj-docx-1-oss-10.1177_01708406231203295 for Prefiguring Alternative Organizing: Confronting marginalization through projective cultural adjustment and tempered autonomy by Babita Bhatt, Israr Qureshi, Dhirendra M. Shukla and Pradeep K. Hota in Organization Studies</p
Topology-aware distributed graph processing for tightly-coupled clusters
No full textCloud applications have burgeoned over the last few years, but they are typically written for loosely-coupled clusters such as datacenters. In this thesis we investigate how one can run cloud applications in tightly-coupled clusters and network topologies, namely super-computers. Specifically, we look at a class of distributed machine learning systems called distributed graph processing systems, and run them on NCSA Blue Waters. Partitioning the graph is key to achieving performance in distributed graph processing systems. We present new topology-aware partitioning techniques that better exploit the structure of the network topologies in supercomputers. Compared to existing work, our new Restricted Oblivious and Grid Centroid partitioning approaches produce 25-33% improvement in makespan, along with a sizable reduction in network traffic. We also discuss optimizations such as smart network buffers that further amplify the improvement. To help operators select the best graph partitioning technique, we culminate our experimental results into a decision tree.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-05-01The student, Mayank Bhatt, accepted the attached license on 2018-04-23 at 17:13.The student, Mayank Bhatt, submitted this Thesis for approval on 2018-04-23 at 17:20.This Thesis was approved for publication on 2018-04-24 at 15:21.DSpace SAF Submission Ingestion Package generated from Vireo submission #12435 on 2018-08-31 at 17:21:19Made available in DSpace on 2018-09-04T20:36:52Z (GMT). No. of bitstreams: 2
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 107297
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 107297 on 2020-09-05T09:15:32Z
An Efficient Control Oriented Modeling Approach for Lithium Ion Cells
No full textLithium ion (Li-ion) batteries are the current
preferred choice for electric vehicles. However the behavior
of Li-ion batteries is complex. In order to safely exploit
their advantages, advanced model-based Battery Management
systems are required. This paper introduces a computationally
efficient, control oriented modeling approach of a Li-ion cell.
The model captures the spatial nature of the dynamics of the
cell in a computationally efficient way. The enabling factor is to
explicitly take advantage of the algebraic structure that arises
from the distributed nature of the model. This yields an efficient
simulation tool and a closed-form state space model that can
be employed for control system design purposes. The proposed
model is validated against a complete CFD model
Space for Opinions
No full textWrede B, Wolter D, Kirsch A, Bhatt M, Kersting K, Meyer U. Space for Opinions. KUENSTLICHE INTELLIGENZ. 2017;31(2):117-119
Erratum: Hybrid group recommendation using modified termite colony algorithm: A context towards big data (Journal of Physical Chemistry (2018) 17:2 (1850019) DOI: 10.1142/S0219649218500193)
No full textWe would like to make the following correction to this article. The third author a±liation should be read as follows: Chintan Bhatt U. & P. U. Patel Department of Computer Engineering Charotar University of Science and Technology Changa, Gujarat 388421, India [email protected]
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