938 research outputs found
Laparoscopic management of gynaecological cancer in pregnancy.
No full textJ Obstet Gynaecol. 2010 Apr;30(3):319-21.
Laparoscopic management of gynaecological cancer in pregnancy.
Berretta R, Rolla M, Ceccaroni M, Benassi G, Modena AB, Nardelli GB.
SourceDepartment of Obstetrics and Gynecology, University of Parma, Parma, Italy. [email protected]
In pregnant women, the incidence of cervical cancer is estimated at around 1 in 10,000 (Amant et al. 2009), while the rate of adnexal masses varies between 2% and 4% (Amant et al. 2009). Approximately 6% of all operated adnexal masses are malignant and the incidence of ovarian cancer during gestation fluctuates from 1 in 10,000 to 1 in 100,000. The purpose of this study was to report our experience with laparoscopy in pregnant women for the management of gynaecological cancer
Sobre ejecución de algunos movimientos de tierras
No full textFil: Berretta, Sebastián. Universidad Nacional de la Capital. Facultad de Ciencias Físico-matemáticas. Buenos Aires; Argentina
Isolated ovarian relapse of pre-b acute lymphoblastic leukemia.
No full textJ Pediatr Adolesc Gynecol. 2009 Aug;22(4):e65-8. Epub 2009 Jun 2.
Isolated ovarian relapse of pre-B acute lymphoblastic leukemia: a case report.
Berretta R, Barone A, Rolla M, Bertolini P, Nardelli GB.
SourceDepartment of Obstetrics and Gynecology, University of Parma, Parma via gramsci 14 -43100, Italy. [email protected]
Abstract
BACKGROUND: Acute lymphoblastic leukemia is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace normal marrow hematopoietic cells, resulting in a marked decrease in the production of normal blood cells.
CASE REPORT: We report a case of isolated ovarian relapse 7 years after the primary diagnosis in a patient, who was seemingly in clinical remission following unilateral ovariectomy and second-line chemotherapy.
CONCLUSION: In contrast to testicular relapse, ovarian relapses in acute lymphoblastic leukemia are rarely reported. Surgical removal of the mass followed by chemotherapy is the therapeutic standard
Uterine smooth muscle tumor of uncertain malignant potential: a three-case report.
No full textInt J Gynecol Cancer. 2008 Sep-Oct;18(5):1121-6. Epub 2007 Nov 6.
Uterine smooth muscle tumor of uncertain malignant potential: a three-case report.
Berretta R, Rolla M, Merisio C, Giordano G, Nardelli GB.
SourceDepartment of Obstetrics and Gynecology, University of Parma, Parma, Italy. [email protected]
Abstract
Based on the degree of cytologic atypia, mitotic activity, and other features, uterine smooth muscle tumors have historically been grouped into two classes: benign leiomyomas and malignant leiomyosarcomas. However, this separation holds true more in principle than in practice because the tumor's biological potential may not always be determined with certainty, complicating diagnosis, and therapy. We report three cases of patients with uterine smooth muscle tumors of uncertain malignant potential. Surgery was radical in two and conservative in one. During the follow-up, one patient developed diffuse lung metastases. The two other patients have not shown any signs of relapse to date. Uterine smooth muscle tumors of uncertain malignant potential may have an unpredictable clinical course and may metastasize to seemingly low-grade neoplasms in distant sites even after several years and even in the absence of important negative prognostic predictors, such as coagulative tumor cell necrosis. At present, no final consensus has been reached on the choice of the best strategy for surgery and adjuvant therapy
Incidence of port-site metastases after laparoscopic pure management of borderline ovarian tumors : a series of 22 patients
No full textEur J Gynaecol Oncol. 2009;30(3):300-2.
Incidence of port-site metastasis after laparoscopic management of borderline ovarian tumors: a series of 22 patients.
Berretta R, Rolla M, Patrelli TS, Gramellini D, Fadda GM, Nardelli GB.
SourceDepartment of Gynecology, Obstetrics and Neonatology, University of Parma, Parma, Italy. [email protected]
Abstract
PURPOSE: The aim of this work was to evaluate the incidence of port-site metastasis in patients undergoing laparoscopy for borderline ovarian carcinoma (BOT).
METHODS: Twenty-two patients who underwent laparoscopy from 2004 to 2008 for BOT were evaluated retrospectively.
RESULTS: In 15 patients an ultraconservative procedure with enucleation of the annexal neoplasia was carried out, while in five (23%) unilateral salpingo-oophorectomy was performed and in two cases (9%) bilateral salpingo-oophorectomy was done.
CONCLUSION: The literature data report few cases of port-site metastasis in BOT patients. Residual cutaneous metastases have been reported to occur within 12 months from the first surgery, generally in association with serous histology. In our analysis, we found 17 out of 22 cases of serous BOT, three mucinous and two endometriod. In no case was cutaneous metastasis revealed after an average of 30 months of follow-up
Vaginal versus abdominal hysterectomy in endometrial cancer: a retrospective study in a selective population
No full textInt J Gynecol Cancer. 2008 Jul-Aug;18(4):797-802. Epub 2007 Oct 18.
Vaginal versus abdominal hysterectomy in endometrial cancer: a retrospective study in a selective population.
Berretta R, Merisio C, Melpignano M, Rolla M, Ceccaroni M, DE Ioris A, Patrelli TS, Nardelli GB.
SourceDepartment of Gynecology, Obstetrics and Neonatology, University of Parma, Parma, Italy. [email protected]
Abstract
The purpose of this study was to analyze the outcome of vaginal and abdominal hysterectomy for the treatment of early-stage endometrial cancer in a selected group of elder patients. This retrospective study analyzed a total of 154 patients: 113 (group I) underwent vaginal surgery and 41 (group II) underwent laparotomy. In both groups, we investigated the following parameters: intra- and postoperative complications, mean operative time, mean hospital stay, disease-free survival (DFS), overall survival (OS), and time of local or retroperitoneal recurrence. Medically compromised patients were significantly more frequent in the vaginal surgery group (P = 0.005), and the operative duration in this group was significantly shorter (P = 0.01). Intra- and postoperative complications, along with local and distant recurrence, did not show a statistically significant difference in the two groups. Total survival in the two populations, 85% at 5 years, did not reach statistically significant difference either in terms of DFS or in terms of OS. Vaginal surgery compared to traditional abdominal approach is feasible also in patients with high surgical risk; it does not require general anesthesia, abolishes abdominal trauma correlated to laparotomy, and allows a quicker reprise of the bladder and rectal function; therefore, it achieves high eradication rates and low intra- and postoperative morbidity rates
Prognostic and predictive response therapy factors in cancer disease (colorectal, breast, liver, lung, gastric, renal and prostate cancers)
No full textExploring prognostic and predictive response therapy factors in cancer disease is one of the most exciting issues of modern oncological science. Targeting intracellular signalling molecules is one of the novel approaches in which basic and translational researches meet clinical practice to define the best management of malignancies. The goal for target therapies is to identify agents that target tumor-specific molecules, thus sparing normal tissues. Those molecules are called biomarkers, and their identification is recommended for correct therapeutic planning. Hence, the contribution of clinical and surgical pathology to define cancer prognostic groups and treatment responsive tumors is essential not only for the efficacy of the cures, but also for ethical, economical, and social reasons. The promises of tailored (personalized) therapy are now almost certainly realistic and can give concrete hope to many cancer patients in the world. In this book, we have tried to describe the "state of art" in these fields of oncology, specifically considering prognostic and predictive response therapy factors in colorectal, breast, lung, gastric, renal, liver and prostate cancers
Randomised prospective study of abdominal wall closure in patients with gynaecological cancer.
No full textAust N Z J Obstet Gynaecol. 2010 Aug;50(4):391-6.
Randomised prospective study of abdominal wall closure in patients with gynaecological cancer.
Berretta R, Rolla M, Patrelli TS, Piantelli G, Merisio C, Melpignano M, Nardelli GB, Modena AB.
SourceDepartment of Obstetrics and Gynecology, University of Parma, Italy. [email protected]
Abstract
BACKGROUND: Median laparotomy is the most common approach to the abdominopelvic cavity in patients with gynaecological tumours.
AIMS: The primary endpoint of the study was to evaluate the onset of incisional hernia. The secondary endpoint was to evaluate the onset of infection, wound dehiscence, wound infection, and scar pain during the post-operative period.
METHODS: A total of 191 patients were eligible for the study. They were divided into three groups. Group A underwent en bloc closure of the peritoneum and fascia with Premilene suture, Group B en bloc closure of the peritoneum and fascia with Polydioxanone suture, and Group C separate closure of the peritoneum and fascia with single stitches of Ethibond suture. Statistical analysis was performed using the Statistical Software Package for Social Sciences 12.0.
RESULTS: Group A and Group B comprised 63 patients, and Group C included 65 patients. The three groups proved homogeneous on statistical analysis (P > 0.05). The statistical analysis did not reveal significant differences between the different suture types and techniques with respect to the incidence of incisional hernia (P > 0.05).
CONCLUSION: In our study, the incidence of incisional hernia was 8%. Randomised patients were homogeneous for sample size and risk factors. No significant differences were found between suture types or techniques. Currently, there is no suture material or technique that can be considered superior to others. When possible, we believe that the best way to prevent incisional hernia is to preserve the integrity of the abdominal wall using minimally invasive techniques
FOLFOX-4 regimen with concomitant highly active antiretroviral therapy in metastatic colorectal cancer HIV-infected patients: a report of five cases and review of the literature.
No full textColorectal cancers are rare in developing countries, but are the second most frequent malignancy in the affluent world. Data on colorectal cancer in HIV-positive patients are limited. Up to now, there are no published data on treatment patterns, response to therapy, or survival in this setting. Oxaliplatin is an antineoplastic agent currently indicated, concomitantly to fluorouracil and leucovorin, for the treatment of advanced colorectal cancer. The FOLFOX-4 regimen (oxaliplatin 85 mg/m(2) as a two-hour infusion on day 1; leucovorin 200 mg/m(2) as a two-hour infusion on days 1 and 2, fluorouracil as a bolus infusion on days 1 and 2, followed by a fluorouracil 22-hour infusion 600 mg/m(2) for two consecutive days every two weeks), with concomitant highly active antiretroviral therapy (HAART) is feasible and active, while the HIV infection is not a limiting factor for its use. Moreover, the concomitant use of HAART does not seem to increase the toxicity of the FOLFOX-4 regimen
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