1,894 research outputs found
COMSOL data files for the publication "3D Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast"
No full textThe zip file contains the COMSOL(COMSOL Multiphysics v5.5; COMSOL AB, Stockholm, Sweden) input files for each of the nanopores simulated in our study "Visualisation of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast"
Authors: Rohan M Lewis, Harikesan Baskaran, Jools Green, Stanimir Tashev, Eleni Paleologou1, Emma M Lofthouse, Jane K Cleal, Anton Page, David S Chatelet, Patricia Goggin, Bram G Sengers.
The paper to be published in iScience
A preprint is also available in Biorxiv doi: https://doi.org/10.1101/2022.01.26.477815</span
General conclusions: innovation systems for ICT: implications for the less developing economies.
No full textThe problem of integrating ICT within national system of innovation: concepts, taxonomies and strategies.
No full text
Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth
No full textCP0 is a multi-functional herpes simplex virus type 1 (HSV-1) immediate-early (IE) gene product that contributes to efficient virus growth and reactivation from latency. Here we show that HSV-1-induced cell-cycle arrest at the G2/M border requires ICP0 and Chk2 kinase and that ICP0 expression by transfection or infection induces ATM-dependent phosphorylation of Chk2 and Cdc25C. Infection of cells with a replication-defective mutant virus deleted for all the regulatory IE genes except ICP0 (TOZ22R) induced G2/M arrest whereas a mutant virus deleted in addition for ICP0 (QOZ22R) failed to do so. Chk2-deficient cells and cells expressing a kinase-deficient Chk2 did not undergo cell-cycle arrest in response to TOZ22R infection. Chk2 deficiency diminished the growth of wild-type HSV-1, but not the growth of an ICP0-deleted recombinant virus. Together, these results are consistent with the interpretation that ICP0 activates a DNA damage response pathway to arrest cells in G2/M phase and promote virus growt
Application of Lab Procedures for the Dynamic Evaluation of Roofing Systems. Part 1: Review of Existing Standards
No full textWind induced effects on roofing systems are dynamic because of the wind's variations with respect totime and space. Experiments were conducted at NRC/IRC on roofing materials . The data reported in"Evaluation of Roof Fasteners Under Dynamic Wind Loading - Baskaran and Dutt (1995)'; clearlyindicated that the fastener failure load and mode differ significantly under dynamic testing as compared tostatic testing. To develop a lab evaluation protocol for the roofing system, existing test procedures weresystematically reviewed. The review includes: the standard lab test methods currently being practiced inNorth America, such as the Factory Mutual (FM 4470) and Underwriters Lab (UL 580) procedures as wellseveral international test procedures used by the roofing community. It has been concluded that theexisting North American test methods are insufficient for evaluating roofing systems since they do notconsider the effects of dynamic wind loading. In Europe, fatigue has been acknowledged as an importantfactor in the evaluation of mechanically attached roofing systems. Thus the European test methods aremore realistic than those adopted in North America.Les effets induits par le vent sur les syst\ue8mes de couverture sont dynamiques en raison des variations du vent par rapport au temps et \ue0 l?espace. Des exp\ue9riences ont \ue9t\ue9 r\ue9alis\ue9es au CNRC/IRC sur des mat\ue9riaux de toiture. Les donn\ue9es signal\ue9es dans Evaluation of Roof Fasteners Under Dynamic Wind Loading, Baskaran et Dutt (1995) ont indiqu\ue9 clairement que la charge extr\ueame et le mode de d\ue9faillance des attaches diff\ue9raient consid\ue9rablement en conditions d?essai dynamique par rapport \ue0 l?essai statique. Afin de mettre au point un protocole d?\ue9valuation en laboratoire pour le syst\ue8me de couverture, on a examin\ue9 syst\ue9matiquement les proc\ue9dures d?essai existantes. Cet examen couvre: les m\ue9thodes d?essai en laboratoire normalis\ue9es qui sont appliqu\ue9es \ue0 l?heure actuelle en Am\ue9rique du Nord, comme celles de la Factory Mutual (FM 4470) et de Underwriter?s Laboratory (UL 580), ainsi que plusieurs proc\ue9dures d?essai internationales qui sont appliqu\ue9es par l?industrie des toitures. On en a conclu que les m\ue9thodes d?essai nord-am\ue9ricaines existantes sont insuffisantes pour l?\ue9valuation des syst\ue8mes de couverture, \ue9tant donn\ue9 qu?elles ne prennent pas en compte les incidences de la surcharge dynamique due au vent. En Europe, on reconna\ueet que la fatigue des mat\ue9riaux est un facteur important dans l?\ue9valuation des syst\ue8mes de couverture fix\ue9s m\ue9caniquement. Ainsi, les m\ue9thodes d?essai europ\ue9ennes seraient plus concr\ue8tes que celles adopt\ue9es en Am\ue9rique du Nord.Peer reviewed: NoNRC publication: Ye
Speleothems as proxy for the carbon isotope composition of atmospheric CO2
No full textWe have measured the stable isotope ratios of carbon in a suite of recent cave deposits (\u3c200 \u3eyears) from the San Saba County, Texas, USA. The methodology for dating these deposits using excess 210Pb was recently established [Baskaran and Iliffe, 1993]. The carbon isotope ratios of these samples, spanning the time period ∼1800–1990 AD, reflect the carbon isotope ratio of atmospheric CO2 for the same period. The pathways by which the δ13C of atmospheric CO2 is imprinted on these speleothems can be explained using a model developed by Cerling (1984). The results suggest that the carbon isotope ratios of speleothems can be used to develop long-term, high-resolution chronologies of the δ13C of atmospheric CO2 and, by implication, the concentration of the atmospheric CO2
Climate change impacts to the Arctic Ocean revealed from high resolution GEOTRACES Po-210-Pb-210-Ra-226 disequilibria studies
No full textAuthor Posting. © American Geophysical Union, 2022. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 127(5), (2022):
e2021JC018359, https://doi.org/10.1029/2021JC018359.Climate change is transforming the Arctic Ocean in unprecedented ways which can be most directly observed in the systematic decline in seasonal ice coverage. From the collection and analysis of particulate and dissolved activities of 210Po and 210Pb from four deepwater superstations, as a part of the US Arctic GEOTRACES cruise during 2015, and in conjunction with previously published data, the temporal and spatial variations in their activities, inventories and residence times are evaluated. The results show that the partitioning of particulate and dissolved phases has changed significantly in the 8 years between 2007 and 2015, while the total 210Po and 210Pb activities have remained relatively unchanged. Observed total 210Po/210Pb activity ratio was less than unity in all deepwater stations, implying disequilibria in the entire water column. From the distribution of total 210Po and 210Pb in the upper 500 m of all major Arctic Basins, the derived scavenging efficiencies decrease as per the following sequence: Makarov Basin > Gakkel Bridge > Canada Basin Nansen Basin ∼ Amundsen Basin > Alpha Ridge, which is the reverse order of the calculated residence times of 210PoT. The scavenging intensities differ between the fully ice-covered, partially ice-covered, and no ice-covered stations, as observed from the differences in the average activities of 210Po and 210Pb. The average settling velocity of particulate matter based on the 210Pb activity is similar to the published values based on 230Th, indicating removal mechanism(s) of Th and Pb is (are) similar.This work was supported by National Science Foundation grants (NSF-PLR-1434578, MB; and NSF-OPP-1435376 KM). Mark Baskaran (PI) and Kanchan Maiti were independently funded by NSF.2022-10-0
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