5,534 research outputs found
Thymic function recovery after unrelated donor cord blood or T-cell depleted HLA-haploidentical stem cell transplantation correlates with leukemia relapse
No full textUse of alternative donors/sources of hematopoietic stem cells (HSC), such as cord blood (CB) or HLA-haploidentical (Haplo)-related donors, is associated with a significant delay in immune reconstitution after transplantation. Long-term T-cell immune reconstitution largely relies on the generation of new T cells in the recipient thymus, which can be evaluated through signal joint (sj) and beta T-cell-Receptor Excision Circles (TREC) quantification. We studied two groups of 33 and 24 children receiving, respectively, HSC Transplantation (HSCT) from an HLA-haploidentical family donor or an unrelated CB donor, for both malignant (46) and non-malignant disorders (11). Relative and absolute sj and beta-TREC values indicated comparable thymic function reconstitution at 3 and 6 months after the allograft in both groups. Compared to children with non-malignant disorders, those with hematological malignancies had significantly lower pre-transplantation TREC counts. Patients who relapsed after HSCT had a significantly less efficient thymic function both before and 6 months after HSCT with especially low beta-TREC values, this finding suggesting an impact of early intra-thymic T-cell differentiation on the occurrence of leukemia relapse. © 2013 Clave, Lisini, Douay, Giorgiani, Busson, Zecca, Moretta, Acquafredda, Brescia, Locatelli and Toubert
Electrochemical fabrication of nanoporous gold decorated with manganese oxide nanowires from eutectic urea/choline chloride ionic liquid. Part III − Electrodeposition of Au–Mn: a study based on in situ Sum-Frequency Generation and Raman spectroscopies
No full textIn two previous papers (C. Mele, M. Catalano, A. Taurino, B. Bozzini. Electrochim. Acta 87 (2013) 918; B. Bozzini, A. Gianoncelli, C. Mele, M. Kiskinova. Electrochim. Acta 114 (2013) 889), we have: (i) fabricated high-capacitance materials consisting of nanoporous gold (NPG)-supported MnO2 nanowires (NW), by electrochemical etching of single-phase Au-Mn alloys electrodeposited from a deep eutectic solvent (DES) electrolyte and (ii) investigated some aspects of the precursor Au-Mn alloy electrodeposition process by following it in situ with space-resolved soft X-ray fluorescence (XRF) and absorption (XAS) microspectroscopies: this study has allowed to single-out the peculiarities of elemental and chemical-state distribution that contribute to the nanostructure fabrication. The present paper completes the electrodeposition study by investigating the potential-dependent interfacial composition of the growing Au-Mn alloys by complementary in situ linear (Raman) and non-linear (Sum-Frequency Generation - SFG) vibrational spectroscopies. The results regarding alloy electrodeposition are compared to those obtained with a pure Au bath. In situ spectroscopy during electrodeposition reveals that both choline cation and urea are present at the growing metal/DES interface, coadsorbed with CN resulting from the decomposition of the Au complex. Electrostatic adsorption controls the surface coverage scenario at the Au/DES interface, while Mn favours the relative surface coverage with urea. Moreover, the interaction of urea with the metal film is modified by the addition of Mn, switching from solid-like to liquid-like at the Mn-alloying potential threshold. Also the CN adsorption scenario is sensitive to surface alloying: the Mn-containing interface shows two adsorption sites with lower degree of metal-adsorbate charge transfer. Finally, the degree of surface enhancement correlates well on the one hand with the applied potential and the interfacial chemistry, and on the other hand with the crystallite morphology induced by alloying Au with Mn. The correlation among the spectroelectrochemical scenario, the potential-dependent alloy composition and the crystallite shape expressed by this investigation fits within the framework set by recent modelling of dynamic electrodeposition morphochemistry and opens up novel opportunities for improving the control over the functional properties of net-shape electrodeposited material
Busson, Mildred M. (Birth, 1902-06-12)
No full textAddress: 1616 South2848/Pg. 72/1902/F W/O/NY./Dr. W. E. ShawOriginal record filed in drawer labeled 'BUSH-CAHILL'
Discours prononcé par M. Busson-Billault,... à l'ouverture de la conférence le 27 novembre 1909 / Barreau de Paris
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Stephanie Busson, Jefford Horrigan, Hunt & Darton, Maria Theodoraki, Ben Judd. Group exhibiton held at James Taylor Gallery, London, 2011
No full textBarreau de Paris. Discours sur Pothier, prononcé le 15 décembre 1849, à la séance d'ouverture des conférences de l'ordre des avocats , par M. Henri Busson,...
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A low thymic function is associated with leukemia relapse in children given T-cell-depleted HLA-haploidentical stem cell transplantation.
No full textBiographie universelle, ou Dictionnaire historique des hommes qui se sont fait un nom par leur génie, leurs talents, leurs erreurs ou leurs crimes. Édition revue et continuée jusqu'en 1848, sous la direction de M. Ch. Weiss,... et de M. l'abbé Busson,... (Tome I (-VIII) avec un supplément jusqu'en mai 1850.). Tome 4
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HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
No full textFew human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha
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