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Dimetilarginina simmetrica (SDMA) e dimetilarginina asimmetrica (ADMA) nel paziente settico
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
ASYMMETRIC (ADMA) AND SYMMETRIC (SDMA) DIMETHYLARGININE IN SEPTIC PATIENTS
No full textRationale: Endothelium-derived NO plays a critical rule in
regulation of blood pressure, preservation of organ perfusion
and interaction between vascular endothelium and
blood platelets/leukocytes. ADMA is an endogenous nonselective
inhibitor of nitric oxide (NO) synthase and SDMA
competes with arginine for cellular transport. The aim of
the study was to investigate if ADMA and SDMA are increased
in ‘‘sepsis syndrome’’ due to protein catabolism and
eventually to decreased epato-renal elimination.
Methods: Twenty-nine consecutive septic patients, as
defined by the ACCP/SCCM1 were enrolled. Blood sampling
was performed on admission day (T0), 3rd(T3), 6th(T6),
9th(T9), 12th(T12). ADMA and SDMA (mmol/L)were measured
by HPLC. ADMA and SDMA were also measured in 77 healthy
volunteers. SAPSII at ICU admission, SOFA score, and sepsis
status1 were recorded daily. Data are presented as
mean7SD. Differences between groups were analysed with
Student’s t-test, ANOVA and Scheffe` test. Significance was
set at po0.05.
Results: Mean ADMA (1.0470.44 vs 0.4670.13, n 1⁄4 116,
po0.0000) and SDMA levels (2.271.3 vs 0.470.09, n 1⁄4 116,
po0.0000), all samples together, are higher than in healthy
volunteers. SDMA level during Severe Sepsis/Septic
Shock(1)days is significantly higher than during Sirs/Sepsis
days (2.471.35 vs 1.8871.22, n 1⁄4 116, p 1⁄4 0.038) while
ADMA (1.170.51 vs 0.9570.29, n 1⁄4 116, p 1⁄4 0.07) shows a
trend. Patients who developed Septic Shock along ICU stay
have higher values of ADMA (1.1370.5, n 1⁄4 64 vs 0.937
0.32, n 1⁄4 52, po0.013) and SDMA (2.6271.48, n 1⁄4 64 vs
1.6970.86, n 1⁄4 52, p 1⁄4 0.0001).
Conclusions: ADMA and SDMA levels are consistently higher
in critically ill septic patients than in healthy volunteers.
These values are even higher in Severe Sepsis/Septic Shock
status
Hypo-osmolar fluid absorption in endoscopic resection: a new pharmacological approach
No full textAim of this letter is the proposal to use enteral Tolvaptan in case of free water absorption in endoscopic surgery.
We report a case of profound hyponatremia after transcervical myomectomy, due to irrigant solutes’ absorption (2.7%
sorbitol/0.54% mannitol solution, containing free water 178 mOsm/L) causing volume overload, dilutional hyponatremia
and possibly pulmonary/brain edema
Dimethylarginines in critically ill patients with severe sepsis or septic shock
Get PDFObjective:We investigated the trend of asymmetric dimethylarginine (ADMA) and symmetryc dimethyarginine (SDMA) in patients with severe sepsis and septic shock, and the relationship between dymethylarginines, organ failure, sepsis status and intensive care unit (ICU) mortality.
Design: A prospective observational study carried out in three general adults Italian ICUs. Patient: Consecutive patients with severe sepsis or septic shock admitted to ICUs between December 2004 and March 2007.
Methods: Plasma ADMA and SDMA were determined immediately after enrolment and on the third, sixth and twelfth days. Organ failure score, sepsis status, standard blood parameters and ICU outcome were collected.
ResulÃ2ts: Twenty-nine consecutive patients were enrolled. ADMA and SDMA were higher in patients than in healthy volunteers. Sixteen patients who suffered from septic shock during ICU stay had a higher avarage value of daily ADMA and SDMA. ADMA was significantly related to arterial pH level, daily Sequential Organ Failure Assessment score and creatinine. Independent variables predicting ICU mortality were Simplified Acute Physiology Score II, mean Sequential Organ Failure Assessment score and SDMA.
Conclusions: Dimethylarginines are not only markers of body catabolism may have a high metabolic activity, tightly related to the risk of adverse outcome of sepsis syndrome
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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