221 research outputs found
Relativistic supernovae have shorter-lived central engines or more extended progenitors: the case of SN 2012ap
No full textDeep, late-time X-ray observations of the relativistic, engine-driven, type Ic SN 2012ap allow us to probe the nearby environment of the explosion and reveal the unique properties of relativistic supernova explosions (SNe). We find that on a local scale of ~0.01 pc the environment was shaped directly by the evolution of the progenitor
star with a pre-explosion mass-loss rate of ̇ M <5 × 10−6Msun/yr, in line with gamma-ray bursts (GRBs) and the other relativistic SN 2009bb. Like sub-energetic GRBs, SN 2012ap is characterized by a bright radio emission and evidence for mildly relativistic ejecta. However, its late-time (δt ≈ 20 days) X-ray emission is ~100 times fainter than the faintest sub-energetic GRB at the same epoch, with no evidence for late-time central engine activity. These results support theoretical proposals that link relativistic SNe like 2009bb and 2012ap with the weakest observed engine-driven explosions, where the jet barely fails to break out. Furthermore, our observations demonstrate that the difference between relativistic SNe and sub-energetic GRBs is intrinsic and not due to line-of-sight effects. This phenomenology can either be due to an intrinsically shorter-lived engine or to a more extended progenitor in relativistic SNe
Polarimetry of the transient relativistic jet of GRB 110328/Swift J164449.3+573451
No full textWe present deep infrared (Ks-band) imaging polarimetry and radio (1.4- and 4.8-GHz) polarimetry of the enigmatic transient Swift J164449.3+573451. This source appears to be a short-lived jet phenomenon in a galaxy at redshift z= 0.354, activated by a sudden mass accretion on to the central massive black hole, possibly caused by the tidal disruption of a star. We aim to find evidence for this scenario through linear polarimetry, as linear polarization is a sensitive probe of jet physics, source geometry and the various mechanisms giving rise to the observed radiation. We find a formal Ks-band polarization measurement of Plin= 7.4 ± 3.5 per cent (including systematic errors). Our radio observations show continuing brightening of the source, which allows sensitive searches for linear polarization as a function of time. We find no evidence of linear polarization at radio wavelengths of 1.4 and 4.8 GHz at any epoch, with the most sensitive 3σ limits as deep as 2.1 per cent. These upper limits are in agreement with expectations from scenarios in which the radio emission is produced by the interaction of a relativistic jet with a dense circumsource medium. We further demonstrate how polarization properties can be used to derive properties of the jet in Swift J164449.3+573451, exploiting the similarities between this source and the afterglows of gamma-ray bursts
Ejection of the Massive Hydrogen-rich Envelope Timed with the Collapse of the Stripped SN 2014C
No full textWe present multi-wavelength observations of SN 2014C during the first 500 days. These observations represent the first solid detection of a young extragalactic stripped-envelope SN out to high-energy X-rays ~40 keV. SN 2014C shows ordinary explosion parameters (Ek ~ 1.8 × 1051 erg and Mej ~ 1.7 M⊙). However, over an ~1 year timescale, SN 2014C evolved from an ordinary hydrogen-poor supernova into a strongly interacting, hydrogen-rich supernova, violating the traditional classification scheme of type-I versus type-II SNe. Signatures of the SN shock interaction with a dense medium are observed across the spectrum, from radio to hard X-rays, and revealed the presence of a massive shell of ~1 M⊙ of hydrogen-rich material at ~6 × 1016 cm. The shell was ejected by the progenitor star in the decades to centuries before collapse. This result challenges current theories of massive star evolution, as it requires a physical mechanism responsible for the ejection of the deepest hydrogen layer of H-poor SN progenitors synchronized with the onset of stellar collapse. Theoretical investigations point at binary interactions and/or instabilities during the last nuclear burning stages as potential triggers of the highly time-dependent mass loss. We constrain these scenarios utilizing the sample of 183 SNe Ib/c with public radio observations. Our analysis identifies SN 2014C-like signatures in ~10% of SNe. This fraction is reasonably consistent with the expectation from the theory of recent envelope ejection due to binary evolution if the ejected material can survive in the close environment for 103–104 years. Alternatively, nuclear burning instabilities extending to core C-burning might play a critical role
Alcohol and lung cancer risk: a pooled analysis using International Lung Cancer Consortium studies
No full textFehringer, G., Brenner, D.R., Zhang, Z.-F., Lee, Y.-C.A., Matsuo, K., Ito, H., Lan, Q., Vineis, P., Johansson, M., Overvad, K., Riboli, E., Trichopoulou, A., Sacerdote, C., Stucker, I., Boffetta, P., Brennan, P., Christiani, D.C., Hong, Y.-C., Landi, M.T., Morgenstern, H., Schwartz, A.G., Wenzlaff, A.S., Rennert, G., McLaughlin, J.R., Harris, C.C., Olivo-Marston, S., Orlow, I., Park, B.J., Zauderer, M., Barros Dios, J.M., Ruano Raviña, A., Siemiatycki, J., Koushik, A., Lazarus, P., Fernández-Somoano, A., Tardon, A., Le Marchand, L., Brenner, H., Saum, K.-U., Duell, E.J., Andrew, A.S., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Holcatova, I., Pesatori, A.C., Consonni, D., Olsson, A., Straif, K., Hung, R.J
Results from a Systematic Survey of X-Ray Emission from Hydrogen-poor Superluminous SNe
No full textInternational audienceWe present the results from a sensitive X-ray survey of 26 nearby hydrogen-poor superluminous supernovae (SLSNe-I) with Swift, Chandra, and XMM. This data set constrains the SLSN evolution from a few days until ∼2000 days after explosion, reaching a luminosity limit L x ∼ 1040 erg s−1 and revealing the presence of significant X-ray emission possibly associated with PTF 12dam. No SLSN-I is detected above , suggesting that the luminous X-ray emission L x ∼ 1045 erg s−1 associated with SCP 60F6 is not common among SLSNe-I. We constrain the presence of off-axis gamma-ray burst (GRB) jets, ionization breakouts from magnetar engines and the density in the sub-parsec environments of SLSNe-I through inverse Compton emission. The deepest limits rule out the weakest uncollimated GRB outflows, suggesting that if the similarity of SLSNe-I with GRB/SNe extends to their fastest ejecta, then SLSNe-I are either powered by energetic jets pointed far away from our line of sight (θ > 30°), or harbor failed jets that do not successfully break through the stellar envelope. Furthermore, if a magnetar central engine is responsible for the exceptional luminosity of SLSNe-I, our X-ray analysis favors large magnetic fields G and ejecta masses , in agreement with optical/UV studies. Finally, we constrain the pre-explosion mass-loss rate of stellar progenitors of SLSNe-I. For PTF 12dam we infer , suggesting that the SN shock interaction with an extended circumstellar medium is unlikely to supply the main source of energy powering the optical transient and that some SLSN-I progenitors end their lives as compact stars surrounded by a low-density medium similar to long GRBs and type Ib/c SNe
Several proliferative phases precede maturation of igg- -secreting cells in mitogen-stimulated cultures.
No full textWave impacts on rectangular structures
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.There is a good deal of uncertainty and sensitivity in the results for wave impact. In a practical situation, many parameters such as the wave climate will not be known with any accuracy especially the frequency and severity of wave breaking. Even if the wave spectrum is known, this is usually recorded offshore, requiring same sort of (linear) transfer function to estimate the wave climate at the seawall. What is more, the higher spectral moments will generally be unknown. Wave breaking, according to linear wave theory, is known to depend on the wave spectrum, see Srokosz (1986) and Greenhow (1989). Not only is the wave climate unknown, but the aeration of the water will also be subject to uncertainty. This affects rather dramatically the speed of sound in the water/bubble mixture and hence the value of the acoustic pressure that acts as a maximum cutoff for pressure calculated by any incompressible model. The results are also highly sensitive to the angle of alignment of the wave front and seawall. Here we consider the worst case scenario of perfect alignment. Given the above, it seems sensible to exploit the simple pressure impulse model used in this thesis. Thus Cooker (1990) proposed using the pressure impulse P(x, y) that is the
time integral of the pressure over the duration of the impact. This results in a simplified, but much more stable, model of wave impact on the coastal structures, and forms the basis of this thesis, as follows:
Chapter 1 is an overview about this topic, a brief summary of the work which will follow and a summary of the contribution of this thesis. Chapter 2 gives a literature review of wave impact, theoretically and experimentally. The topics covered include total impulse, moment impulse and overtopping. A summary of the present state of the theory and Cooker’s model is also presented in Chapter 2. In Chapter 3 and Chapter 4, we extend the work of Greenhow (2006). He studied the berm and ditch problems, see Chapter 3, and the missing block problem in Chapter 4, and solved the problems by using a basis function method. I solve these problems in nondimensionlised variables by using a hybrid collocation method in Chapter 3 and by using the same method as Greenhow (2006) in Chapter 4. The works are extended by calculating the total impulse and moment impulse, and the maximum pressure arising from the wave impact for each problem. These quantities will be very helpful from a practical point of view for engineers and designers of seawalls. The mathematical equations governing the fluid motion and its boundary conditions are presented. The deck problem together with the mathematical formulation and boundary conditions for the problem is presented in Chapters 5 and 6 by using a hybrid collocation method. For this case, the basis function method fails due to hyperbolic terms in these formulations growing exponentially. The formulations also include a secular term, not present in Cooker’s formulation. For Chapter 5, the wave hits the wall in a horizontal direction and for Chapter 6, the wave hits beneath the deck in a vertical direction. These problems are important for offshore structures where providing adequate freeboard for decks contributes very significantly to the cost of the structure. Chapter 7 looks at what happens when we have a vertical baffle. The mathematical formulation and the boundary conditions for four cases of baffles which have different positions are presented in this chapter. We use a basis function method to solve the mathematical formulation, and total impulse and moment impulse are investigated for each problem. These problems are not, perhaps, very relevant to coastal structures. However, they are pertinent to wave impacts in sloshing tanks where baffles are used to detune the natural tank frequencies away from environmental driving frequencies (e.g ship roll due to wave action) and to damp the oscillations by shedding vortices. They also provide useful information for the design of oscillating water column wave energy devices. Finally, conclusions from the research and recommendations for future work are presented in Chapter 8.This work is funded by the Ministry of Higher Education Malaysia and Universiti Pendidikan Sultan Idris, Malaysia
Mesothelioma. Scientific clues for prevention, diagnosis, and therapy
No full textMesothelioma affects mostly older individuals who have been occupationally exposed to asbestos. The global mesothelioma incidence and mortality rates are unknown, because data are not available from developing countries that continue to use large amounts of asbestos. The incidence rate of mesothelioma has decreased in Australia, the United States, and Western Europe, where the use of asbestos was banned or strictly regulated in the 1970s and 1980s, demonstrating the value of these preventive measures. However, in these same countries, the overall number of deaths from mesothelioma has not decreased as the size of the population and the percentage of old people have increased. Moreover, hotspots of mesothelioma may occur when carcinogenic fibers that are present in the environment are disturbed as rural areas are being developed. Novel immunohistochemical and molecular markers have improved the accuracy of diagnosis; however, about 14% (high-resource countries) to 50% (developing countries) of mesothelioma diagnoses are incorrect, resulting in inadequate treatment and complicating epidemiological studies. The discovery that germline BRCA1-asssociated protein 1 (BAP1) mutations cause mesothelioma and other cancers (BAP1 cancer syndrome) elucidated some of the key pathogenic mechanisms, and treatments targeting these molecular mechanisms and/or modulating the immune response are being tested. The role of surgery in pleural mesothelioma is controversial as it is difficult to predict who will benefit from aggressive management, even when local therapies are added to existing or novel systemic treatments. Treatment outcomes are improving, however, for peritoneal mesothelioma. Multidisciplinary international collaboration will be necessary to improve prevention, early detection, and treatment
- …
