83 research outputs found
Increased Enthesopathy in Patients With Familial Mediterranean Fever Evaluation With a New Sonographic Enthesitis Index
No full textConclusions-This study showed significant enthesopathy in patients with familial Mediterranean fever. The findings support the hypothesis that familial Mediterranean fever and spondyloarthropathy may have common inflammatory mechanisms and suggest that the MASEI scoring system can be incorporated into clinical protocols for studying patients with familial Mediterranean fever in daily practice
Sonographic Evaluation of Subclinical Entheseal Involvement in Patients With Behcet Disease
No full textCONCLUSION. This is the first study to our knowledge to show significant subclinical enthesopathy of the triceps tendon enthesis in patients with Behcet disease who had no arthritic involvement. These data suggest that the Madrid sonography enthesitis index scoring system for sonographic detection of enthesopathy should be incorporated into the clinical protocol for evaluating patients with Behcet disease in routine clinical practice
The effect of colchicine on the peritoneal membrane
No full textPeritoneal dialysis (PD) is a treatment modality for patients with renal failure. Peritoneal fibrosis is one of the most serious complications after long-term continuous ambulatory peritoneal dialysis (CAPD). Histological studies in both humans and animals show that chronic peritoneal dialysis results in fibrosis of the peritoneal membrane. In our study, we investigated the effect of colchicine on peritoneal alterations induced by hypertonic PD solution in rats. Sprague-Dawley rats intraperitoneally received saline (control group) once daily, for 28 days, or 3.86% glucose (PDF group), or 3.86% glucose plus colchicine (colchicine group). Animals from each group were sacrificed after 28 days with anesthetized ketamine (60 mg/kg BW). For the PD fluid assessment, 1 h before the sacrifice of animals, 10 mL PD fluid of 2.27% glucose was given, and this fluid was obtained after the sacrifice. The levels of transforming endothelial growth factor ss (TGF-ss), tumor necrosis factor alpha (TNF-alpha) and albumin were investigated both in the peritoneal dialysate and blood, and the levels of malondialdehyde (MDA) were investigated only in peritoneal dialysate. The peritoneal membrane was evaluated histologically by light microscopy. When groups were compared in terms of body weight change, the colchicine group significantly lost weight compared to controls and PDF group (-4.7% 4.5, 3.5% 7.2, 3.0% 1.3, respectively, p = 0.018). Also, the blood albumin level was significantly lower for these in the colchicine group compared to those in the PDF group (2.7 0.35 versus 3.2 0.3 g/dL, respectively, p = 0.048). The blood TGF-ss level was significantly lower in the control group, and no difference was observed between the PDF and colchicine groups (294.4 67.5 versus 787.4 237.4 versus 615.3 235.1 pg/mL, respectively, p = 0.004). The mesothelial thickness found in groups was as follows: control group 102 18.9 mu m, PDF group 128.33 33.1 mu m, colchicine group 117 35.6 mu m ( p = 0.34). In conclusion, a rat model for peritoneal dialysis associated peritoneal derangement without fibrosis could be induced. Colchicine could not prevent peritoneal derangement in this model
The evaluation of coagulation parameters and vessel involvement in Behcet' s disease. A clinical experience of Behcet' s disease: Study of 152 cases
No full textBehcet's disease (BD) is accepted as a systemic vasculitis. Vasculitis is observed predominantly on the venous system. Vessel involvement is frequently seen in males. This study was planned retrospectively evaluate demographic features, clinical features, vessel involvements in BD. Furthermore, we aimed to prospectively compare consecutively chosen patients with and without thrombosis and healthy volunteers in terms of their biochemical, immunological, coagulation parameters. One hundred fifty-two Behcet´s patients were retrospectively evaluated. Blood samples were collected from 52 consecutively chosen patients and 41 healthy subjects. Papulopustular skin lesions, eye involvement and venous lesions were detected frequent in males. In terms of evaluated parameters (biochemical parameters, coagulation parameters, C-reactive protein, erythrocyte sedimentation rate, anticardiolipin antibodies, antinuclear antibody positivity) was not found a significant difference among groups (patients without thrombosis, healthy control subjects, patients with thrombosis). We detected statistically significant difference in terms of factor V levels between patient and control group. The tendency to thrombosis in patients with BD is well known. The endothelial lesion, increased procoagulant activity, hypofibrinolysis were found to be responsible from these events. In our study, there was no significant difference in terms of coagulation parameters between the patients without and with thrombosis. © 2013 Tehran University of Medical Sciences. All rights reserved
Mycophenolate mofetil use in hepatitis B associated-membranous and membranoproliferative glomerulonephritis induces viral replication
No full textRelation between left ventricular and/or left atrial thrombus and anticardiolipin antibodies in patients with acute myocardial infarction
No full textThis study was designed to determine the relation between anticardiolipin antibodies and left atrial and/or left ventricular thrombus detected by transthoracic and/or transesophageal echocardiography in patients with acute myocardial infarction, Patients with acute myocardial infarction who had positive anticardiolipin immunoglobulin G and/or immunoglobulin M antibodies appeared to be at higher risk for thrombus formation in the left atrium and/or left ventricle
Remitting seronegative symmetrical synovitis with pitting edema syndrome associated with non-Hodgkin's lymphoma: a case report
No full textColchicine-induced myopathy in a teenager with familial editerranean fever
No full textOBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF)
Short Communication Nutritional Status and Immune Functions in Maintenance Hemodialysis Patients
No full textEpidemiological studies suggest various kinds of immune dysregulation in hemodialysis (HD) patients. The aim of this study was to investigate the relationship between immune functions and nutritional status of HD patients. We studied 54 patients with ESRD on chronic HD, included 34 females and 20 males with mean age 46.6 ± 16.3 (18-77) years. We measured the height and dry weight of all patients. The BMI was calculated by dividing weight (kg) by height squared (m 2 ). In all patients serum urea, creatinine, albumin, iron, cholesterol, triglyceride, CRP, IgG, IgM, IgA, CD4, CD8, CD19, CD16-56 lymphocytes were measured. Kt/V values were calculated according to DOQI guideline. In this study, a positive correlation between albumin, cholesterol, and triglyceride levels as nutritional parameters and immune functions in terms of total and subtype lymphocyte counts was observed. Further prospective studies are needed to determine the clinical importance of this finding and the appropriate means of measurement and effects of nutrition on immune function in hemodialysis patients
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