1,721,492 research outputs found
Abstract IA15: Genetic screens to study cancer
No full textAbstract
We will describe our efforts to use the CRISPR/Cas9 system to systematically identify the genetic liabilities of cancer cells and the synthetic lethal relationships of common oncogenes.
Citation Format: David M. Sabatini. Genetic screens to study cancer [abstract]. In: Proceedings of the AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; Jan 4-7, 2017; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2017;16(10 Suppl):Abstract nr IA15.</jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Energy analysis methods and tools for modelling and Optimizing monitoring tyre systems
Full text linkVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Assessment of the vulnerability of industrial sites to acts of interference
No full textConsequences of attacks or acts of interference involving industrial sites where relevant quantities of dangerous substances are processed or stored (as in the case of process or pharmaceutical industries) may result in severe consequences. On the security side, several Security Vulnerability Assessment (SVA) methods were developed to analyze the problem. However, all the SVA procedures deal mainly with “security” and target vulnerability, but not with “safety” and not with the assessment of the possible consequences of acts of interference.
The present study was dedicated to the development of a method for the quantitative assessment of the vulnerability of a target to acts of interference. The aim of the work was to develop a method that could be useful to understand the potential consequences of attacks or of acts of interference, oriented to land use and emergency planning, as well as to prioritize protection actions
Intentional acts of interference: attractiveness and vulnerability of industrial sites
No full textConsequences of attacks or acts of interference involving industrial sites where relevant quantities of dangerous substances are processed or stored (as in case of chemical or process industries) may result in severe consequences. On the security side, several Security Vulnerability Assessment (SVA) methods were developed to analyze the problem. However, all the SVA procedures deal mainly with “security” and target vulnerability, but not with “safety” and not with the assessment of the possible consequences of acts of interference.
The present study was dedicated to the development of a method for the quantitative assessment of the vulnerability of a target to acts of interference. The aim of the study was to develop a method that could be useful to understand the potential consequences of attacks or of acts of interference, oriented to land use and emergency planning, as well as to prioritize protection actions. Some case studies were considered to test the application of the methodology
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