2,364 research outputs found
Diane M. Ingle
No full textDiane M. Ingle receives an award for 20 years of service in Academic Affairs. (l-r) President William Perry, Diane M. Ingle, Provost Blair Lord.https://thekeep.eiu.edu/years_of_service_2013/1073/thumbnail.jp
Letter from John I. Ingle, D.D.D, University of Southern California, School of Dentistry, to Janet Kuromi and family; Letter from George J. Inagaki to Mrs. Kuromi, January 28, 1970
No full textLetter from John I. Ingle to Janet Kuromi and family stating that a gift from Ronald James Wong to the Alumni Memorial Fund for the School of Dentistry at the University of Southern California has been made in Yoke Kuromi's name. Attached to the back is a handwritten sympathy letter from George J. Inagaki to Mrs. Kuromi.This collection contains two photograph albums and material related to Hitoshi "Yoke" Kuromi and Corrine Nobuko Nishimura Kuromi. Subjects in the collection include the Kuromi family, the Gila River incarceration camp, and hot rods, and classic cars
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Letter to Robert M. Ingle from H.B. Stenzel on 1962-05-14
No full textJackson School of Geoscience
Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3
No full textSwapnil Gaikwad,1 Avinash Ingle,1 Aniket Gade,1 Mahendra Rai,1 Annarita Falanga,3 Novella Incoronato,2 Luigi Russo,2 Stefania Galdiero,3 Massimilano Galdiero2 1Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India; 2Department of Experimental Medicine, Division of Microbiology, II University of Naples, 3Department of Pharmacy, University of Naples “Federico II”, DFM and Institute of Biostructures and Bioimages, Naples, Italy Abstract: The interaction between silver nanoparticles and viruses is attracting great interest due to the potential antiviral activity of these particles, and is the subject of much research effort in the treatment of infectious diseases. In this work, we demonstrate that silver nanoparticles undergo a size-dependent interaction with herpes simplex virus types 1 and 2 and with human parainfluenza virus type 3. We show that production of silver nanoparticles from different fungi is feasible, and their antiviral activity is dependent on the production system used. Silver nanoparticles are capable of reducing viral infectivity, probably by blocking interaction of the virus with the cell, which might depend on the size and zeta potential of the silver nanoparticles. Smaller-sized nanoparticles were able to inhibit the infectivity of the viruses analyzed. Keywords: silver nanoparticles, antiviral, herpes simplex virus, parainfluenza viru
Relationship between the early Kerguelen plume and continental flood basalts of the paleo-Eastern Gondwanan margins
No full textCretaceous basalts recovered during Ocean Drilling Program Leg 183 at Site 1137 on the Kerguelen Plateau show remarkable geochemical similarities to Cretaceous continental tholeiites located on the continental margins of eastern India (Rajmahal Traps) and southwestern Australia (Bunbury basalt). Major and trace element and Sr-Nd-Pb isotopic compositions of the Site 1137 basalts are consistent with assimilation of Gondwanan continental crust (from 5 to 7%) by Kerguelen plume-derived magmas. In light of the requirement for crustal contamination of the Kerguelen Plateau basalts, we re-examine the early tectonic environment of the initial Kerguelen plume head. Although a causal role of the Kerguelen plume in the breakup of Eastern Gondwana cannot be ascertained, we demonstrate the need for the presence of the Kerguelen plume early during continental rifting. Activity resulting from interactions by the newly formed Indian and Australian continental margins and the Kerguelen plume may have resulted in stranded fragments of continental crust, isolated at shallow levels in the Indian Ocean lithosphere
Vision, attention and action in posterior cortical atrophy and other dementias
No full textPosterior Cortical Atrophy (PCA) is a rare, progressive dementia characterised
by visuospatial and visuoperceptual deficits (often with intact visual acuity),
and a generally younger age of onset than typical Alzheimer’s disease (AD)
(Aresi & Giovagnoli, 2009; Caixeta, Taleb, Ghini, Dias Soares, de Melo Caizera &
Vargas, 2013; Mendez, Ghjarania & Perryman, 2002). Patients with PCA
typically present with fewer memory deficits, better verbal fluency, and better
insight into their diagnosis compared with typical AD, although PCA and AD
tend to converge clinically at advanced stages of disease progression (Lehmann
et al., 2012). Despite being identified by Benson and colleagues three decades
ago, there are still no widely agreed clinical diagnostic criteria for PCA and it
remains relatively poorly understood (Benson, Davis & Snyder, 1988; Crutch et
al., 2017).
This PhD study was comprised of two phases. The initial screening phase
involved a diverse battery of assessments with two main aims. First, this battery
was intended to investigate the sensitivity and specificity of different screening
tests in discriminating PCA patients (n = 6) from patients with other
neurodegenerative dementias (n = 21) (typical Alzheimer’s disease,
frontotemporal dementia, Lewy body dementia, corticobasal degeneration, and
primary progressive aphasia). The Modified Luria Alternating Square and
Triangles (M-LAST) task achieved the highest sensitivity and specificity, closely
followed by target cancellation and bisection tasks. The M-LAST task has not
been reported previously in the assessment of PCA patients, but may have
considerable potential for use in diagnostic settings. Similarly, an unusual
variant of the bisection task (gap bisection, McIntosh et al., 2004) yielded the
most impressive sensitivity for PCA. The secondary aim of the screening phase
was to identify whether patients with other neurodegenerative diseases
demonstrated deficits on the assessments which were specific to early visual
function, as this is an area that has not been addressed previously in the
literature. There was evidence of significant impairment for patients other than
PCA on a number of measures. However, the most striking results from patients
with dementias other than PCA were obtained on the second phase of
assessment.
The second laboratory-based phase aimed to more fully characterise the
visuoattentional deficits associated with PCA (n = 5) and other dementias (n =
13), through the use of eye-tracking and motion-tracking technology. The PCA
patients proved difficult to test under these conditions, as their visual
impairments were so advanced and generalised that they appeared almost
functionally blind on some tests. The most exciting novel results were obtained
from patients with AD, in whom evidence of optic ataxia (misreaching to
peripheral targets) was found for three of the four AD patients tested on a
pointing task. These results, discussed in context with other recently published
evidence (Gordon et al., 2018), suggest that screening for optic ataxia may have
potential as a behavioural symptom potentially sensitive to early neuronal
changes associated with AD.
A systematic review of the literature was conducted in order to investigate the
use of visual attention or visuomotor-specific assessments in the evaluation of
patients with PCA. A case study was conducted of visual form agnosic patient
DF, in whom recent evidence of optic ataxia has been found (Rossit et al., 2018;
Hesse, Ball & Schenk, 2012, 2014). Strong evidence of optic ataxic-like pointing
errors was observed in patient DF, with preserved grip scaling, implicit
avoidance of obstacles and perceptual matching. An additional study on healthy
participants was conducted in order to test whether attentional demands
modulate performance on a visuomotor pointing task. The results indicated that
increasing attentional demands led to optic ataxic-like pointing errors, thus the
experimental manipulation appeared to serve as a model of optic ataxia in the
healthy brain
Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects.
No full textThere are alarming reports of growing microbial resistance to all classes of antimicrobial agents used against different infections. Also the existing classes of anticancer drugs used against different tumours warrant the urgent search for more effective alternative agents for treatment. Broad-spectrum bioactivities of silver nanoparticles indicate their potential to solve many microbial resistance problems up to a certain extent. The antibacterial, antifungal, antiviral, antiprotozoal, acaricidal, larvicidal, lousicidal and anticancer activities of silver nanoparticles have recently attracted the attention of scientists all over the world. The aim of the present review is to discuss broad-spectrum multifunctional activities of silver nanoparticles and stress their therapeutic potential as smart nanomedicine. Much emphasis has been dedicated to the antimicrobial and anticancer potential of silver nanoparticles showing their promising characteristics for treatment, prophylaxis and control of infections, as well as for diagnosis and treatment of different cancer types
Passive Inter-Photon Imaging
No full textDigital camera pixels measure image intensities by converting incident light energy into an analog electrical current, and then digitizing it into a fixed-width binary representation. This direct measurement method, while conceptually simple, suffers from limited dynamic range and poor performance under extreme illumination - electronic noise dominates under low illumination, and pixel full-well capacity results in saturation under bright illumination. We propose a novel intensity cue based on measuring inter-photon timing, defined as the time delay between detection of successive photons. Based on the statistics of inter-photon times measured by a time-resolved single-photon sensor, we develop theory and algorithms for a scene brightness estimator which works over extreme dynamic range; we experimentally demonstrate imaging scenes with a dynamic range of over ten million to one. The proposed techniques, aided by the emergence of single-photon sensors such as single-photon avalanche diodes (SPADs) with picosecond timing resolution, will have implications for a wide range of imaging applications: robotics, consumer photography, astronomy, microscopy and biomedical imaging
Municipal commonage in South Africa: A public good going bad?
No full textThis article deals with the ‘Cinderella' of urban spaces – municipal commonage. The author argues that commonage is a valuable natural heritage resource. However, municipalities face pitfalls in giving expression to central policymakers' dictates regarding land redistribution. A warning is issued that by trying to turn the clock back to commonage policies more suited to a bygone era, municipalities run the risk of forfeiting both the income their commonage has the potential to generate and the very asset itself. The author contends that, until government can offer municipalities a coherent, viable model for commonage management, it would be folly to abandon the system of renting out commonage to the highest bidders. Africa Insight Vol. 36 (2) June 2006: 46-5
Silver Nanoparticles as Novel Antibacterial and Antiviral Agents
No full textAdvanced and innovative technologies are continuously dedicated to the understanding of
the mechanisms of diseases and to the design of new drugs, but infectious diseases continue
to be one of the greatest health burdens worldwide. The main drawbacks for conventional
antimicrobial agents are the development of multiple drug resistance and adverse side
effects. Advances in nanotechnology have produced novel horizons in nanomedicine,
enabling the synthesis of nanoparticles that could be assembled into complex architectures.
Among these, silver nanoparticles are attracting great interest owing to their potent
antibacterial and antiviral activity. This chapter summarizes emerging efforts to tackle the
current challenges in treating infectious diseases, particularly using antimicrobial silver
nanoparticles. Silver nanoparticles toxicity is also addressed to disclose the concerns
against widespread application in the medical fi eld
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