450 research outputs found
Heat Generated by Mechanical Agitation and Lactose Metabolism during Continuous Propagation of Kluyveromyces fragils in Cheese Whey
No full textRosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is an Invited Paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 5 (2003): A.E. Ghaly and N.S. Mahmoud. Heat Generated by Mechanical Agitation and Lactose Metabolism during Continuous Propagation of Kluyveromyces fragils in Cheese Whey. Vol. V. May 2003
Enhanced Lactic Acid Production from Cheese Whey with Nutrient Supplement Addition
No full textRosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is an Invited Paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 5 (2003): A.E. Ghaly, M.S.A. Tango, and M.A. Adams. Enhanced Lactic Acid Production from Cheese Whey with Nutrient Supplement Addition. Vol. V. May 2003
Targeting Breast Cancer: Synthesis and Biological Evaluation of Novel D-Fructose Based Molecular Imaging Agents And Cytotoxic Noscapine Analogues
No full textAmong the characteristic hallmarks of cancer cells is their high replicative potential, which in turn leads to the overexpression of the facilitative hexose transporters (GLUTs) to provide the energy required for cell growth and proliferation. Interestingly, in 1996 the major D-fructose transporter (GLUT5) was identified to be overexpressed in breast cancer cells compared to their healthy counterparts. The first part of this thesis describes the synthesis and biological evaluation of four C-2 fluorescently labeled D-fructose derivatives that were developed to target GLUT5. Based on the findings with the fluorescently labeled compounds, an optimized synthetic pathway was developed for the synthesis of the corresponding C-2 modified D-fructose derivatives bearing a fluorinated side chain. This pathway can be applied for the synthesis of [18F] PET imaging agents. The second part of this thesis describes the design and synthesis of novel noscapine analogues as cytotoxic agents targeting microtubules. Nine new compounds have been successfully synthesized and biologically evaluated as potential antiproliferative agents. Interestingly, one of the developed analogues showed superior cytotoxic activity over the parent noscapine molecule. Computational data suggest binding of these compounds to both colchicine and noscapine binding sites; however, a higher affinity to the colchicine site
Poems of Sheikh Muhammad al-Ghaly Ba
No full textThis volume contains seven poems handwritten by Muhammad al-Ghāli Ba. According to the author's son, Mountaga Ba, the poems were probably composed in the mid-1970s a time when the author lived in Mauritania, while working at the country's national radio station and serving as a special counsel to then president Moktar Ould Daddah (1924–2003). The poems adress various issues. The first is a call to action addressed to the Mauritianian youth, urging them to join in the collective work for the development of the country. The second poem is a hagiography on Ceerno Ahmad Nene Ba of Kaedi (Mauritania). The poem eulogizes the virtues of the patron. The third describes the event of Sharif Muhammad al-Habib's visit to the region of Fuuta region (Senegal), namely the village of Pate Galo. The fourth poem contains greetings and expresions of love addressed to the author's friends in the town of Kaedi. The fifth poem is a remembrance about good times. The author reminisces and praises the qualities of a woman named Jaari.The sixth poem describes one afternoon journey of the author. The seventh poem is a mournful praisesong in which the author laments the loss of a cherished person.Ce volume contient sept poèmes manuscrits de Muhammad al-Ghāli Ba. Selon le fils de l'auteur, Mountaga Ba, les poèmes ont probablement été composés au milieu des années 1970, à une époque où l'auteur vivait en Mauritanie, alors qu'il travaillait à la radio nationale du pays et était conseiller spécial du président de l'époque, Moktar Ould Daddah (1924). –2003). Les poèmes abordent diverses questions. Le premier est un appel à l'action adressé aux jeunes mauriciens, les exhortant à s'associer au travail collectif pour le développement du pays. Le deuxième poème est une hagiographie sur Ceerno Ahmad Nene Ba de Kaedi (Mauritanie). Le poème fait l'éloge des vertus du mécène. Le troisième décrit l'événement de la visite de Sharif Muhammad al-Habib dans la région de la région de Fuuta (Sénégal), à savoir le village de Pate Galo. Le quatrième poème contient des salutations et des expressions d'amour adressées aux amis de l'auteur dans la ville de Kaedi. Le cinquième poème est un souvenir des bons moments. L'auteur rappelle et loue les qualités d'une femme nommée Jaari. Le sixième poème décrit un après-midi de voyage de l'auteur. Le septième poème est une louange mélancolique dans laquelle l'auteur déplore la perte d'une personne chérie
fish and fishery products microbiology bacteria causing fish spoilage
No full textThis material describe bacteria which causing spoilage in fish and seafood products
Additional file 2 of Exploring virus-host-environment interactions in a chemotrophic-based underground estuary
No full text<b>External Organisations</b><br/>Macquarie University; University of Technology Sydney; Department of Primary Industries (New South Wales)<b>Associated Persons</b><br/>Timothy M. Ghaly (Creator); Amaranta Focardi (Creator); Liam D. H. Elbourne (Creator); Brodie Sutcliffe (Creator); Paul R. Jaschke (Creator); Sasha G. Tetu (Creator); Ian T. Paulsen (Creator)Supplementary Material
Innovative method of utilising hydrogen peroxide for source water management of cyanobacteria
No full textThe treatment and control of cyanobacterial blooms using copper-based algaecides in water reservoirs have historically been used; however, due to the adverse impact of copper on the environment, water authorities have been researching and studying new and innovative ways to control cyanobacterial blooms. Hydrogen peroxide has been investigated as an environmentally friendly alternative, and this research aims to determine the impact of water quality on its effectiveness based on the decay characteristics in different water samples. Natural water samples from South Australian reservoirs and river were used to evaluate hydrogen peroxide decomposition and provide a better strategy for water operators in using it as an algaecide. Our experiments show the dependency of hydrogen peroxide decomposition not only on water quality but also on the initial hydrogen peroxide dose. A higher initial hydrogen peroxide dose can trigger the increase of pH, leading to increased consumption of hydrogen peroxide. In addition, the hydrogen peroxide decomposition is significantly accelerated with the rise of copper concentration in water samples. Moreover, it is found that UV light can also affect the decomposition rate of hydrogen peroxide. The hydrogen peroxide decay is more significant under UV light for the samples with lower hydrogen peroxide concentrations. Our study also shows the impact of dissolved organic carbon (DOC) on hydrogen peroxide decomposition is not substantial. The study also presents a modelling method to optimise hydrogen peroxide application based on water quality characteristics. Our findings can provide knowledge for the water industry to produce a suitable model which can be used to optimise the application of hydrogen peroxide for the control of cyanobacteria.Full Tex
Synthesis and biological evaluation of structurally simplified noscapine analogues as microtubule binding agents
No full text This paper reports on the results of chemical synthesis and biological assays performed on several new analogues of noscapine. We have successfully synthesized four noscapine analogues called 1a–4a, as well as their four corresponding enantiomers called 1b–4b. The chemical pathway consisted of three steps with yields in excess of 60% in each step. Subsequently, we have performed biological activity assays intended to reveal the mode of action of these compounds on microtubules in buffer and in cancer cell lines. We have assayed fluorescence quenching effects in microtubule polymerization experiments, cytotoxicity evaluation in breast cancer cell lines, as well as microtubule dynamicity assessments, for each of the synthesized compounds. Finally, we performed computational docking simulations to two binding sites on β-tubulin: (a) the colchicine binding site and (b) the noscapine binding site. Our results indicate that these compounds have relatively low cytotoxicity profile and less pronounced effects on microtubule dynamics compared with noscapine. Our computational results indicate that these compounds bind to both putative binding sites but have higher affinity for the colchicine site. </jats:p
The growth of large mining firms in Australia: case-study: C.R.A. Ltd.
No full text© 1981 Shafik M. GhalyTo discuss the issue of the growth of business firms fully would carry us through the whole economic theory and practice. Rather than pursuing the question through all its ramifications, I intend to deal with some aspects of the integration of business enterprise which have immediate bearing on the characteristics of firms and their relationships with one another.
Regardless of the method used to integrate business activities, such method must be flexible, that is, being capable of accommodating a changing population of firms performing changing operations. To achieve such flexibility, more than one flexible method of integration may be used. There are three basic methods which may be mixed in varying proportions in any particular situation, namely, integration by administration, by market transactions and by co-operation,
Since we do not have one firm within which all business activities are integrated by administration, we have to face the problems of what determines the boundaries of firms boundaries of geography, of processes of products and of size and what determines the choice between the other two basic methods of integration, the market and co-operation, which are used to co-ordinate activities beyond the boundaries of firms.
In this part an attempt will be made to discuss briefly the following issues:
(a) Why do firms specialise in particular processes and products?
(b) Why are some firms more specialised than others?
(c) What determines the size of the firm?
(d) What are the merits of the three basic ways of integrating business activities? (From Introduction
Perencanaan Teknis Bendung Padasan II, Desa Ngawen, Kabupaten Pati
No full textBendung Padasan II dibangun pada tahun 1976 terletak di Daerah Irigasi Gembong, Desa Ngawen, Kabupaten Pati, Jawa Tengah. Desain Eksisting Bendung Padasan II adalah Mercu tipe Ogee dan Kolam Olak tipe Vlugter yang mampu mengaliri sawah dengan luas 47,30 Ha. Pada tahun 2019 terjadi banjir pada Bendung Padasan II yang mengakibatkan lahan pertanian. Dampak dari kejadian ini semakin meningkat dikarenakan daya dukung tanah yang buruk yang mengakibatkan gerusan lokal sedalam 1 meter pada hilir bendung dan lereng sungai. Untuk itu, perlu dilakukan perencanaan teknis Bendung Padasan II untuk menyelesaikan permasalahan tersebut.
Dalam melakukan perencanaan bangunan utama dan bangunan pelengkap pada Bendung Padasan II direncanakan desain bendung pada Mercu Bendung tipe Bulat dan Kolam Olak tipe USBR III sesuai dengan standar Kriteria Perencanaan (KP) Irigasi. Untuk analisis stabilitas lereng digunakan metode Fellenius dan untuk desain Dinding Penahan Tanah (DPT) digunakan metode Meyerhof . Sedangkan, untuk analisis transpor sedimen bed load digunakan metode Meyer Peter Muller (MPM) dan untuk transpor sedimen suspended load digunakan metode Chang Simon & Richardson. Berdasarkan hasil analisis didapatkan tinggi mercu bendung 1,35 m dengan elevasi mercu bendung +7,178, tipe mercu bulat dengan jari – jari 0,77 m, elevasi dasar intake bendung +6,453, lebar efektif bendung 7,64 m, dan tipe kolam olak USBR III sepanjang 8 meter. Untuk desain Dinding Penahan Tanah (DPT) memiliki dimensi tinggi 5,35 m dan lebar 3 meter yang diperkuat dengan 1 minipile ukuran 20 x 20 cm sedalam 3 meter. Sedangkan untuk transpor sedimen, penuhnya sedimen pada sisi hulu bendung diperkirakan selama 4 tahun.
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Padasan II Weir was constructed in 1976 and is located in the Gembong Irrigation Area, Ngawen Village, Pati Regency, Central Java. The existing design of Padasan II Weir features an ogee crest and a Vlugter-type stilling basin, capable of irrigating 47.30 hectares of rice fields. In 2019, a flood occurred at Padasan II Weir, causing significant damage to agricultural land. The impact of this incident worsened due to poor soil support, leading to local scouring up to 1 meter deep in the downstream area of the weir and riverbanks. Therefore, technical planning for the reconstruction of Padasan II Weir is necessary to address these issues. In planning the main and supplementary structures of Padasan II Weir, a rounded crest design and a USBR III-type stilling basin have been proposed following the standards of Irrigation Planning Criteria (Kriteria Perencanaan Irigasi). For slope stability analysis, the Fellenius method is used, while the retaining wall (DPT) design is based on the Meyerhof method. Bed load sediment transport analysis employs the Meyer Peter Muller (MPM) method, while suspended load transport analysis uses the Chang, Simon & Richardson method. Based on the analysis, the weir crest height is 1.35 m with a crest elevation of +7.178 m. The weir features a rounded crest design with a radius of 0.77 m, an intake base elevation of +6.453 m, an effective weir width of 7.64 m, and a USBR III-type stilling basin with a length of 8 meters. The design of the retaining wall (DPT) includes dimensions of 5.35 m in height and 3 m in width, reinforced with one mini-pile measuring 20 x 20 cm and a depth of 3 meters. Regarding sediment transport, the upstream sediment is estimated to reach full capacity within four years
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