3,941 research outputs found
Maurizio Galimberti. Il viaggio, la Sicilia, Gibellina
No full textIl contributo è dedicato al lavoro del fotografo Maurizio Galimberti sulle architetture e le opere d'arte della città di Gibellina nuova e dei ruderi di Gibellina vecchia. Galimberti interpreta con rara sensibilità l’unicità del fascino di questa città rasa al suolo dal terremoto della Valle del Belìce del 1968. ricostruita 20 km più a valle cogliendo le suggestioni dell’incontro tra cultura e natura, arte e rovine. Attraverso le fotografie selezionate per il libro d'artista intitolato "Gibellina" Galimberti dialoga così con artisti di caratura internazionale tra cui Alberto Burri, Fausto Melotti, Alessandro Mendini.The contribution is dedicated to the work of the photographer Maurizio Galimberti on the architecture and works of art of the new city of Gibellina and the ruins of old Gibellina. Galimberti interprets with rare sensitivity the uniqueness of the charm of this city razed to the ground by the 1968 Belìce Valley earthquake. Rebuilt 20 km further downstream, capturing the suggestions of the encounter between culture and nature, art and ruins. Through the photographs selected for the artist's book entitled "Gibellina" Galimberti thus dialogues with internationally renowned artists including Alberto Burri, Fausto Melotti, Alessandro Mendini
Classification Trees for Ordinal Responses in R: The rpartScore Package
No full textThis paper introduces rpartScore (Galimberti, Soffritti, and Di Maso 2012), a new R package for building classification trees for ordinal responses, that can be employed whenever a set of scores is assigned to the ordered categories of the response. This package has been created to overcome some problems that produced unexpected results from the package rpartOrdinal (Archer 2010). Explanations for the causes of these unexpected results are provided. The main functionalities of rpartScore are described, and its use is illustrated through some examples
Supporting urban planning to stay with uncertainty: Preparedness, care, and antifragility
No full textReligion in Herodian
No full textThe History of the Empire from the Death of Marcus of Herodian in eight books, written in Greek, is a key source for the period from the reign of Commodus (AD 180) to that of Gordian III (238). Herodian is an eyewitness and the only contemporary historian whose work has come down to us in full. His point of view is all the more valuable because he is an outsider with respect to both court historiography, whose flattery he stigmatized, and to senatorial historians, represented mainly by Cassius Dio and by the biographies in the Historia Augusta. Nonetheless, Herodian has often been harshly criticized as a historian. To better understand the relevance of his historiographical approach and his historical thought the paper intends to show the different wisdoms that religion takes on in Herodian's work and shows how the author was insensitive to the topic
Classification Trees for Ordinal Responses in R: The rpartScore Package
No full textThis paper introduces rpartScore (Galimberti, Soffritti, and Di Maso 2012), a new R package for building classification trees for ordinal responses, that can be employed whenever a set of scores is assigned to the ordered categories of the response. This package has been created to overcome some problems that produced unexpected results from the package rpartOrdinal (Archer 2010). Explanations for the causes of these unexpected results are provided. The main functionalities of rpartScore are described, and its use is illustrated through some examples
Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma
No full textS Galimberti, M PetriniDepartment of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, Pisa, ItalyAbstract: Patients with mantle cell lymphoma (MCL) have a poor prognosis; consequently, new therapeutic approaches, such as rapamycin and its derivates, mammalian target of rapamycin (mTOR) inhibitors, are warranted. Temsirolimus (also known as CCI-779), a dihydroester of rapamycin, in MCL cell lines inhibited mTOR, downregulated p21 and v-Raf, and induced autophagy.The first clinical trial in MCL patients was performed using 250 mg of temsirolimus weekly for 6–12 cycles. The overall response rate was 38%; the median time to progression was 6.5 months, median overall survival was 12 months, and the median duration of response was 6.9 months. At lower dose (25 mg/week), the overall response rate was 41%, median overall survival was 14 months, and time to progression was 6 months. In another trial, 162 patients were randomly assigned to receive temsirolimus at 2 different doses (175 mg/week for 3 weeks, then 75 mg or 25 mg/week) or a treatment chosen by the investigator among the most frequently adopted single agents for treatment of relapsed MCL. Patients treated with 175/75 mg of temsirolimus had significantly higher response rates and longer progression-free survival than those treated with investigator’s choice therapy. These data support the use of mTOR inhibitors for the treatment of MCL, probably in combination with other agents, such as antiangiogenic drugs or histone acetylase inhibitors.Keyword: mTOR rapamycin, PI3K/Akt, p7056K, 4E-BP
Afterword. Preparedness supporting the transition
No full textTo understand the COVID-19 outbreak and its socio-spatial nature, this book stemmed from the hypothesis that the concept of preparedness is an insightful one, worth to be (re)discussed within the urban and regional studies and, particularly the urban planning and policy field. This hypothesis did represent an open question rather than a consolidated view. This conclusive chapter recaps the main points made in the volume and outlines the definition of preparedness emerging from the chapters. Finally, it argues that preparedness shall not only be intended as an emergency technique to address unforeseeable changes but more broadly as a technology supporting a sustainable spatial and economic transition
Preparedness as a technology of the imagination. Interview with Andrew Lakoff and Frédéric Keck
No full textThis chapter provides an interview with two anthropologists: Frédéric Keck, Director of the Laboratory of Social Anthropology (CNRS-Collège de France-EHESS), and Andrew Lakoff, Professor of Sociology and Communication (University of Southern California). They have long wondered about the relationship between public action, emergency, and the construction of biosecurity devices, focusing on the construction of preparedness. It seems to us a perspective of great interest to understand the limits and possibilities of taking a preparedness approach in terms of urban planning and policy
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