1,917 research outputs found
Terras de Collu
No full textThe stratigraphic and systematic position of two perrisodactyl remains, ?Paralophiodon sardus and Atalonodon monterinii, collected in Early Eocene deposits in Terras de Collu (south-western Sardinia) is discussed
High Speed Marine Vehicles With Aerodynamic Surfaces: Development of a Dynamic Model for a Novel Configuration.
No full textA research programme on high speed marine vehicles fitted with aerodynamic
surfaces started in Cranfield University in 2005. One of the configurations
analyzed is a high speed prismatic planing hull with one or more aerodynamic
surfaces; it is called a hybrid vehicle (HV). Two mathematical models have been
developed for the dynamic behavior which is a combination of the very different
behaviors of aircraft and ships. The first model estimates the equilibrium
attitude of the HV at a certain speed. A parametric analysis for the influence
of the configuration on the performance of the HV has been conducted (1). With
the second model, the authors propose a set of ordinary differential equations
of motion, derived in the frame of small-disturbance stability theory which has
been used to investigate the longitudinal dynamic stability of the HV (2). Ref.
(1) and (2) present a complete description of the mathematical models, while
this article summarizes the methodology adopted to develop these dynamic models
and gives a brief summary of the results. (1) COLLU, M., PATEL, M. H., TRARIEUX,
F., A Mathematical Model to analyze the Static Stability of Hybrid (Aero-
hydrodynamically supported) vehicles., 8th Symposium on High Speed Marine
Vehicles 2008 (HSMV08), Naples, Italy, 2008. (2) COLLU, M., PATEL, M. H.,
TRARIEUX, F., A Unified Mathematical Model for High Speed Hybrid (Air and Water-
borne) Vehicles., 2nd International Conference on Marine Research and
Transportation, 2007
On mooring line tension and fatigue prediction for offshore vertical axis wind turbines: A comparison of lumped mass and quasi-static approaches
No full textDespite several potential advantages, relatively few studies and design support tools have been developed for floating vertical axis wind turbines. Due to the substantial aerodynamics differences, the analyses of vertical axis wind turbine on floating structures cannot be easily extended from what have been already done for horizontal axis wind turbines. Therefore, the main aim of the present work is to compare the dynamic response of the floating offshore wind turbine system adopting two different mooring dynamics approaches. Two versions of the in-house aero-hydro-mooring coupled model of dynamics for floating vertical axis wind turbine (FloVAWT) have been used, employing a mooring quasi-static model, which solves the equations using an energetic approach, and a modified version of floating vertical axis wind turbine, which instead couples with the lumped mass mooring line model MoorDyn. The results, in terms of mooring line tension, fatigue and response in frequency have been obtained and analysed, based on a 5 MW Darrieus type rotor supported by the OC4-DeepCwind semisubmersible
Yawning is elicited by D2 dopamine agonists but is blocked by the D1 antagonist, SCH 23390
No full textDopamine hypothensis of affective disorders: Behavioural, Biochemical and Electrophysiological evidences from chronic treatment with antidepressants.
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Recognition of Imipenem and Meropenem by the RND-Transporter MexB Studied by Computer Simulations
No full textBasic understanding of the means by which multidrug efflux systems can efficiently recognize and transport drugs constitutes a fundamental step toward development of new compounds able to tackle the continuous outbreak of new bacterial strains resistant to traditional antibiotics. We applied a series of computational techniques, from molecular docking to molecular dynamics simulations and free energy estimate methods, to determine the differences in the binding properties of imipenem and meropenem, two potent antibiotics of the carbapenem family, to MexB, the pump subunit of the major RND efflux system of Pseudomonas aeruginosa. We identified and characterized two affinity sites in the periplasmic domain of the transporter, sharing strong similarities with the distal and proximal binding pockets identified in AcrB, the homologue of MexB in Escherichia coli. According to our results, meropenem has a higher affinity to the distal binding pocket than imipenem while both compounds are weakly bound to the proximal pocket. This different behavior is mainly due to the hydration properties of the nonpharmacophore part of the two compounds, being that of imipenem less bulky and hydrophobic. Our data provide for the first time a rationale at molecular level for the experimental evidence indicating meropenem as a compound strongly affected by MexB contrary to imipenem, which is apparently poorly transported by the same pump
"Chiral Ligands Containing Heteroatoms. 15. Cyclic b-Amino Alcohols as Chiral Inductors for Enantioselective Reductions of Ketones"
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