1,156 research outputs found
Data for: Genetic structure of a small brood-stock population of cobia (Rachycentron canadum) through pedigree analyses
No full textThe original data in MS-Excel file has been uploaded
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Broadcasters' right in the digital era ::copyright concerns on live streaming /
No full text"In Broadcasters' Rights in the Digital Era, Sakthivel provides a cogent understanding into a hitherto unchartered territory on the applicability of copyright law on the live streaming of 'entertainment content'- an emerging medium of communication. The book examines in exhaustive breadth the scope of broadcasters' neighbouring rights under the copyright regime in the light of technological advancements vis-à-vis authors' right and explores the experiences of EU & USA and then suggests suitable changes to the Indian Copyright regime. Sakthivel employs technological analysis and existence of differential market for different mediums to substantiate the relationship of live streaming and the copyright regime"
Estimation of safe stand off distances for r.c. framed buildings
No full textThis paper discusses the assessment of blast load and its effect on reinforced concrete framed buildings. Using the direct solution of the multi-degree of freedom equations of motion, a method for analyzing r.c. columns is presented. The work demonstrates that solutions achieved using single degree of freedom equations of motion can underestimate the shear force in columns by as much as 50%. This finding is of importance with regard to robustness assessments of buildings carried out using TM5-1300. A method for estimating the safe stand off distance for reinforced concrete columns is presented together with application against the Murrah building collapse, by way of a case study. The Murrah Building collapse has been widely attributed to the use of transfer girders at the third floor level. The building is reanalyzed with a more conventional arrangement of beams and columns and the results show that a substantial progressive collapse could have occurred even if a transfer girder had not been used
sj-docx-1-pie-10.1177_09544089231207476 - Supplemental material for Can pretrained networks be used in fault diagnosis of monoblock centrifugal pump?
No full textSupplemental material, sj-docx-1-pie-10.1177_09544089231207476 for Can pretrained networks be used in fault diagnosis of monoblock centrifugal pump? by Arun Balaji M, Naveen Venkatesh S, Sakthivel N R and Sugumaran V in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
Selective screening for DDH in Wessex: the Southampton experience
No full textIntroduction: There is some debate about the pros and cons of selective screening of DDH in neonates as opposed to general screening. General screening puts a lot of stress on the resources available, especially in the modern day NHS, but the advocates state that this minimises the cost incurred in treating a missed DDH (by selective screening) with surgery later on.Aim: The aim of this retrospective study was to find out the effectiveness of the Southampton selective screening of babies with risk factors for DDH by finding out the number of patients presenting late with an established DDH.Materials And Methods: 6116 babies out of 26,932 live births (22.7%) in Southampton were screened between 1998 and 2003. The details of the individual outcomes and the reasons for the late presentation were obtained from the patient notes and the records of the screening program which are maintained in the clinics and by the senior author.Results: 248 new patients had Pavlik’s harness fitted for the treatment of DDH which presents a treatment rate of 0.92%. 8 patients (0.03%) presented late because they did not undergo ultrasound scanning as they did not have the risk factors as required by this selective program. 10 (0.036%) failed Pavlik’s and needed late surgery to have their DDH treated. The total operation rate was 0.066%.Discussion: The late presentation of patients in this screening program is very low and comparable to the other papers from this department and from around the world. The cost implications of treating these 8 late presenting patients was found to be a lot cheaper than carrying out a general screening program which would mean, in this case 4 times more than the cost of the present screening program
Co-stimulatory molecules : genes to protein in autoimmune and inflammatory disorders
No full textCo‐stimulatory molecules are antigen‐independent generators of secondary signals which aid in maintaining the homeostasis of the immune system. The most extensively studied co‐stimulatory pathway is CD28/CTLA‐4, expressed on the T cells, interacting with CD80/CD86, expressed on the antigen presenting cells (APC). The interaction between CD28 and CD80/CD86 initiates the activation of T cells, whereas subsequent interaction between CTLA‐4 and CD80/CD86 inhibits the activated T lymphocytes. Also, there exist several other co‐stimulatory pathways. The co‐stimulatory molecules analyzed, in this study are B7H3, CD28, CD80, CD86, CTLA‐4, PD‐1, PD‐L1 and PD‐L2.This study involves both with genetic associations and protein expression of co‐stimulatory molecules (either stimulatory or inhibitory) in case‐control and population‐based studies. In the case‐control study, we categorized two types of model diseases: 1) the B‐cell induced autoantibody mediated disease, myasthenia gravis (MG) and 2) the T‐cell mediated inflammatory diseases, abdominal aortic aneurysm (AAA). In the population based study, we have selected subjects aged above 70 in the county of Uppsala, Sweden.At the genetic level, the key role of inhibitory receptors, B7H3 and Programmed Death‐1 (PD‐1), were evaluated in MG. No significant differences in genotype frequencies or allele frequencies in MG patients when compared with controls were found. The study, with PD‐ 1, was extended at mRNA and protein expression levels. Though we could not demonstrate any significant differences at mRNA levels, there was an increased expression of PD‐1 and PD‐L1 on T cells and monocytes, respectively. This demonstrates the existence regulatory mechanism behind MG.The soluble (s) forms of co‐stimulatory molecules sCD28, sCD80, sCD86, sCTLA‐4 were evaluated in patients with AAA and in general population. We could demonstrate increased circulating levels of soluble forms of CD28, CD86 and decreased levels of soluble forms of CTLA‐4 among AAA patients when compared with controls. In the general population, levels of soluble forms of co‐stimulatory molecules were positively related to pro‐inflammatory cytokines such as TNF‐α, IL‐6, IL‐1α, IL‐1β, IFN‐γ and chemokines such as IL‐8, but inversely related to CC chemokine, MCP‐1. We could not demonstrate any direct relation of soluble co‐stimulatory molecules to adhesion molecules and other atherosclerotic factors. The detection of soluble forms of PD‐1 could be demonstrated neither in the patients with MG nor in the controls.In conclusion, we suggest that the co‐stimulatory molecules have a significant impact on the status of the immune activation behind the two types of disorders. Therefore, we suggest that sCD28, sCD80, sCD86, sCTLA‐4 could be used as biomarkers for evaluating the process of inflammation. Furthermore, our study suggests a natural regulation of MG through the interaction between PD‐1/PD‐L1.List of scientific papersI. Sakthivel P, Wang X, Gharizadeh B, Giscombe R, Pirskanen R, Nyren P, Lefvert AK (2006). Single-nucleotide polymorphisms in the B7H3 gene are not associated with human autoimmune myasthenia gravis. J Genet. 85(3): 217-20. https://pubmed.ncbi.nlm.nih.gov/17406098 II. Sakthivel P, Shively V, Kakoulidou M, Pearce W, Lefvert AK (2007). The soluble forms of CD28, CD86 and CTLA-4 constitute possible immunological markers in patients with abdominal aortic aneurysm. J Intern Med. 261(4): 399-407. https://pubmed.ncbi.nlm.nih.gov/17391115 III. Sakthivel P, Wermeling F, Gu M, Hulthe J, Elmgren A, Kakoulidou M, Lefvert AK. Lind L (2007). Soluble CD28, CD80, CD86 and CTLA ]4 are related to CRP and proinflammatory cytokines and chemokines in elderly Caucasians. [Submitted]IV. Sakthivel P, Ramanujam R, Wang XB, Pirskanen Matell, Lefvert AK (2007). Programmed Death ]1: from gene to protein in autoimmune human myasthenia gravis. Journal of Neuroimmunology. [Accepted] https://pubmed.ncbi.nlm.nih.gov/18037500 </p
Pompano farming at Vethalai using low-cost cages: Technology demonstration initiative by Mandapam RC
Get PDFAn artisanal type of cage was fabricated at Mandapam Regional
Centre with 6×6 m outer and 5×5 m inner square frame,
which is made of 50mm GI pipe for farming demonstrations involving
local fishermen at Vethalai village, Ramnad District, Tamil Nadu.The ongoing pompano farming
demonstration in an artisanal type of sea cages is a way forward for
the spread of mariculture in India.
(Reported by G. Gopakumar,
A. K. Abdul Nazar, R. Jayakumar, G. Tamilmani,
M. Sakthivel, C. Kalidas, P. Ramesh Kumar &
Johnson B., Mandapam Regional Centre
Artisanal innovation in cage farming of pompano at Vethalai, Ramanathapuram
Get PDFOn 25th July 2012, pompano from an artisanal cage was
harvested. The total harvest was 92 kg, the length and weight
ranges observed were 16 to 32 cm and 62 to 433 grams.The harvest was handed over to the farmer Shri.Nagadoss
by Dr. G. Gopakumar, Scientist-in-Charge. The farm gate price
for the harvested pompano was `120/kg- and it was sold by
the merchant in the retail market at `180/kg-.
Reported by G.Gopakumar, A. K. Abdul Nazar,
R. Jayakumar, G. Tamilmani, M. Sakthivel, C. Kalidas,
P. Ramesh Kumar & Johnson B., Mandapam Regional Centr
Detection and Analysis of Lysozyme Activity in some Tuberous Plants and Calotropis Procera’s Latex
Get PDFTuber extract of all the plant species used in the study exhibited lysozyme activity confirming the ubiquitous presence of lysozyme in plants. Among the different plants screened for protein content the tuber extract of Solanum tuberosum showed highest buffer soluble protein while tuber extract of Raphanus sativus showed the lowest protein content in sodium acetate buffer (50 Mm; pH 5.0). Tuber extract of Raphanus sativus showed highest lysozyme activity among all the plant species tested in this study and the activity was increased when the tuber was extracted with sodium phosphate buffer (50mM; pH 7.0). The lowest lysozyme was observed with tuber extract of Daucus carota in phosphate buffer (50mM; pH 7.0). The latex of the tropical species Calotropis procera is well known for being a rich source of the lysozyme. Lysozyme of Calotropis procera latex is not thermo labile. It did not lose much of its activity when the latex was incubated at different temperatures for 24 hours. A positive pointer for purification of this enzyme in future. Calotropis procera lysozyme can be was specifically isolated and purified from the whole latex with ammonium sulphate precipitation with 95% saturation. Calotropis procera lysozyme retained its activity even after precipitation with ammonium sulphate and dialysis and could hydrolyse the cell wall of Micrococcus lysodeikticus.Key words: Micrococcus lysodeikticus, Tuberous Plants, Latex, Ammonium sulphate precipitation, Polyacrylamide gel electrophoresis M. Sakthivel et al. Detection and Analysis of Lysozyme Activity in some Tuberous Plants and Calotropis Procera’s Latex. J Phytol 2/11 (2010) 65-72
Design principles to ascertain the manoeuvrability of small offshore vessels in the conceptual design stage: Manoeuvring vs. course-keeping
No full textMechanical, Maritime and Materials EngineeringMaritime and Transport Technology (M&TT
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