178,408 research outputs found
A note on the category of c-spaces
No full textWe prove that the category of c-spaces with continuous maps is not cartesianclosed. As a corollary the category of locally finitary compact spaces withcontinuous maps is also not cartesian closed.Comment: 5 page
Mathematica notebook and C++ code for studying the tidal effects of compact-object binary systems
No full textThese Mathematica notebook and C++ code are associated to the following paper:
Xuefeng Feng, Zhenwei Lyu, and Huan Yang(2021). "Black-Hole Perturbation Plus Post-Newtonian Theory: Hybrid Waveform for Neutron Star Binaries". arXiv preprint arXiv:2104.11848, 2021.
The Mathematica notebook is based on José M. Martín-García, GPL 2002-2021, "xAct:Efficient tensor computer algebra for the Wolfram Language".
The C++ code is based on the Greamlin code of "Black Hole Perturbation Toolkit".https://bhptoolkit.org/toolkit.htm
Coccoglypta leprosula Páll-Gergely & Hunyadi & Chen & Lyu 2019, n. comb.
No full textCoccoglypta leprosula (Heude, 1885) n. comb. (Fig. 6I-L) Helix leprosa Heude, 1885a: 106, pl. 27, fig. 15. Helix leprosula Heude, 1885b: 43. Helix (Satsuma) leprosula – Tryon 1887: 220, pl. 51, figs 80-82. MATERIAL EXAMINED. — China. Sichuan, Mianyang Shi, Jiangy- ou Shi, Wudu Zhen, Guanwushan Forest Farm; 31°56’38.8”N, 104°44’1.1”E; 1590 m; A. Hunyadi & M. Szekeres leg.; 21 -22. VI.2015; coll. HA; 1 adult + 2 juvenile shells (Coccoglypta cf. leprosula n. comb., Figures 6 I-L). TYPE LOCALITY. — “Tchen K’eou” (Chengkou, Chongqing Province). REMARKS Johnson (1973) did not mention type specimens in American museums, and we could not contact the Beijing Natural History Museum, where some of Heude’s types are deposited. Therefore, we rely on the original description only. Accordingly, the shell is 26 mm wide, narrowly umbilicated, and the sculpture is finely tuberculated, as in Coccoglypta. The specimen we examined matches the original description, but the identification is certainly doubtful. It was collected c. 370 km west from the type locality of “ Satsuma ” leprosula. However, it must be kept in mind that the type locality is just a rough estimate, Heude received specimens from other missionaries who collected shells during their travels across large geographic areas.Published as part of Páll-Gergely, Barna, Hunyadi, András, Chen, Zhe-Yu & Lyu, Zhi-Tong, 2019, A review of the genus Coccoglypta Pilsbry, 1895 (Gastropoda: Pulmonata: Camaenidae), pp. 595-608 in Zoosystema 41 (29) on page 604, DOI: 10.5252/zoosystema2019v41a29, http://zenodo.org/record/372611
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Coccoglypta arbusticola Páll-Gergely & Hunyadi & Chen & Lyu 2019, n. comb.
No full textCoccoglypta arbusticola (Deshayes, 1870) n. comb. (Fig. 6A-D) Helix arbusticola Deshayes, 1870: 20. non Bradybaena arbusticola arbusticola – Yen 1939: 135, pl. 14, fig. 2. non Coccoglypta arbusticola – Chen & Zhang 2004: 155-156, fig. 123. TYPE MATERIAL EXAMINED. — China. Moupin [Muping Zhen, Sichuan], l’Abbé David, 1869, syntype, MNHN-IM-2000-34192. TYPE LOCALITY. — “Principauté de Moupin, Thibet oriental” (from title). REMARKS This species has previously been assigned to the genus Bradybaena, however it surely does not belong to that genus in its present concept. The type species of Bradybaena, B. similaris (Rang, 1831), has a small (c. 1 cm), fragile shell without any distinctive sculpture. However, C. arbusticola n. comb. is larger (shell diameter of syntype: 24.5 mm), and has a thick, finely mamillated shell, reminiscent of those of Coccoglypta. We have examined the lectotype of Eulota arbusticola chrysomphala Möllendorff, 1899 (see Möllendorff, 1899: 70 and Yen, 1939: 135) in the Senckenberg Museum (China: W. Sy-tshuan, Fu-bien-ho, SMF 9159, figs 6E-H). It had a light brown, very finely wrinkled and extremely finely spirally grooved shell, without any signs of mamillae. The aperture is also comparatively much larger in chrysomphala than in arbusticola. Thus, “ Bradybaena ” chrysomphala and Coccoglypta arbusticola n. comb. cannot be subspecies of the same species and must be considered as two distinct species. The single shell in the Senckenberg Museum identified as B. arbusticola and figured by Yen (1939) has a narrower umbilicus and more rapidly growing whorls than the type, and there are also no signs of a mamillated sculpture. Therefore, we here exclude it from the present species. Its true identity remains unknown. Furthermore, the shell figured in Chen & Zhang (2004) also belong to another species, because it has a narrower umbilicus, a dark spiral band, and a more strongly expanded peristome.Published as part of Páll-Gergely, Barna, Hunyadi, András, Chen, Zhe-Yu & Lyu, Zhi-Tong, 2019, A review of the genus Coccoglypta Pilsbry, 1895 (Gastropoda: Pulmonata: Camaenidae), pp. 595-608 in Zoosystema 41 (29) on pages 602-604, DOI: 10.5252/zoosystema2019v41a29, http://zenodo.org/record/372611
Toward a New Generation of Design Tools for the Digital Multiverse
No full textWithin the Industry 4.0 context, different digital twins (DTs) are used to analyse manufacturing systems and assist decision-making processes throughout their entire life cycle. This means that many professionals, with various roles and cultures, build and use their own DTs; hence, methods and tools are required to ensure that the so taken decisions are consistent. This chapter formally proposes a design tool that will help professionals deal with this important issue, allowing them not only to establish and check relations among project data but also to integrate different model-based DTs with one another. The tool specification builds on the recently introduced digital multiverse (DM) paradigm, where all DTs are viewpoints on the same common knowledge corpus, called Model and Data Base
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Resolution based Feature Distillation for Cross Resolution Person Re-Identification
No full textPerson re-identification (re-id) aims to retrieve images of same identities across different camera views. Resolution mismatch occurs due to varying distances between person of interest and cameras, this significantly degrades the performance of re-id in real world scenarios. Most of the existing approaches resolve the re-id task as low resolution problem in which a low resolution query image is searched in a high resolution images gallery. Several approaches apply image super resolution techniques to produce high resolution images but ignore the multiple resolutions of gallery images which is a better realistic scenario. In this paper, we introduce channel correlations to improve the learning of features from the degraded data. In addition, to overcome the problem of multiple resolutions we propose a Resolution based Feature Distillation (RFD) approach. Such an approach learns resolution invariant features by filtering the resolution related features from the final feature vectors that are used to compute the distance matrix. We tested the proposed approach on two synthetically created datasets and on one original multi resolution dataset with real degradation. Our approach improves the performance when multiple resolutions occur in the gallery and have comparable results in case of single resolution (low resolution re-id)
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Structural investigation of teleost immunoglobulin M tetramer assembly and engineering of chimeric antibodies consisting of teleost motifs
No full textSubmission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01The student, Mengfan Lyu, accepted the attached license on 2025-04-25 at 18:26.The student, Mengfan Lyu, submitted this Dissertation for approval on 2025-04-25 at 22:34.This Dissertation was approved for publication on 2025-04-29 at 11:07.DSpace SAF Submission Ingestion Package generated from Vireo submission #21998 on 2025-10-19 at 19:54:11This thesis investigates novel structural and functional aspects of teleost and chimeric immunoglobulin M (IgM), providing critical insights into antibody assembly mechanisms and antibody therapeutic engineering applications. Through single-particle cryo-electron microscopy (cryo-EM) and functional analyses, we have characterized previously unknown structural features of teleosts polymeric immunoglobulins and applied structural insights into engineering chimeric antibodies. The research presents the first high-resolution cryo-EM structure of teleost IgM-Fc, revealing a joining chain (JC)-independent assembly mechanism distinct from human counterparts. The teleost IgM tetramer comprises eight heavy chains with identical amino acid sequences that adopt two distinct CHμ4 conformational folds, facilitating a unique assembly where four IgM-Fcs are linked through C-terminal tailpieces (Tps) forming a β-sandwich-like domain. This arrangement differs significantly from the human pentameric IgM-J complex, highlighting an alternative polymeric (p) Ig assembly mechanism. Further structural investigations of chimeric IgM-Fc scaffolds comprising human and teleost sequences (cFcμs) and hexameric human IgM revealed additional representatives of JC-independent pIgM assemblies. The cFcμs form pentamers with distinctive configurations where C-terminal tailpieces protrude from the plane shared by cFcμ monomers—a structural characteristic unique to these chimeric constructs. Comparative analyses across teleost and human IgM assemblies provided insights into the evolutionary diversification of pIg assembly mechanisms and supported the role of JC as a template for Tps association into β-sheets. To explore the potential of cFcμs in antibody engineering, we engineered cFcμ scaffolds fused with single-domain antibodies (sdAbs) targeting clinically relevant pathogens: Clostridioides difficile and influenza A virus. These sdAb-cFcμ fusion constructs formed polymers that exhibited promising functions, including bacterial crosslinking and viral neutralization with high potency. These findings demonstrated the practical applications of cFcμ scaffolds and highlight their potential as antimicrobial therapeutics. This research contributes significantly to structural immunology by revealing the remarkable structural plasticity of polymeric immunoglobulin throughout the evolution of jawed vertebrates and highlighting the potential of IgM-based engineered polymeric antibodies for therapeutic applications. The cFcμ scaffolds developed in this study offer a promising platform for antibody engineering, particularly for applications requiring high avidity and multivalent target binding
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