83,262 research outputs found
7.01.004: Comic strip re: computers with caption "No problem, Don Walsh will know what to do," commissioned by Sheila Lynch
No full textSheila Lynch gave me this with a gift one year.This items is a Rich Tennant cartoon to which Sheila M.P. Lynch has added her own caption
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
No full textLynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families
Historical Notes on Whooping Cranes at White Lake, Louisiana: The John J. Lynch Interviews, 1947–1948
No full textIn May 1939 biologist John J. Lynch of the U.S. Bureau of Biological Survey conducted an aerial survey that documented the existence of a non-migratory population of whooping cranes (Grus americana) near White Lake in southwest Louisiana. Lynch found 13 cranes, including 2 pre-fledged young, confirming breeding. Lynch’s survey occurred, in part, because fur trappers and alligator hunters working in the White Lake marshes had informed the biologist of the cranes’ presence and habits. Lynch continued his contacts with these knowledgeable marsh users, and in 1947 and 1948 interviewed at least 7 individuals. In 2001, M. L. Courville, along with her sister Nora Z. Lynch, discovered the interview notes among their father’s papers. The notes contain information on the Louisiana non-migratory population’s range, abundance, habitat use, feeding behavior, nesting, and young, including survival of twins; they also include a small amount of information on sandhill cranes (Grus canadensis) and migratory whooping cranes. Both Lynch and Robert P. Allen relied heavily on this “traditional ecological knowledge” in their accounts of non-migratory whooping cranes in southwest Louisiana. Because of their biological and historical significance, the interview notes are reproduced in this paper. Many marsh users remain in the White Lake area, and their knowledge could aid future research and crane reintroduction efforts in the region
Without mercy: The immediate impact of group size on lynch mob atrocity
No full textTwo independent research traditions have focused on social contributions to lynching. The sociological power threat hypothesis has argued that lynching atrocity will increase as a function of the relative number of African Americans. The psychological self-attention theory has argued that lynching atrocity will increase as a function of the relative number of mob members. Two series of analyses (one using newspaper reports and the second using photographic records) using different and nonoverlapping samples of lynching events rendered a consistent pattern of results: Lynch mob atrocity did not increase as a function of the relative numbers of African Americans in the county population but it did increase as a function of the relative numbers of mob members in the lynch mob. Discussion considers the implications of these results
Primary malignant pericardial tumour in Lynch syndrome
No full textBackground: This case represents the first report of malignant primary cardiac tumour in a patient with Lynch Syndrome associated with MSH2 pathogenic variant. Case presentation: A 57-year-old woman with previous ovarian cystadenocarcinoma was admitted to the emergency room for hematic pericardial effusion. Multimodal diagnostic imaging revealed two solid pericardial vascularized masses. After pericardiectomy, the final histological diagnosis was poorly differentiated pleomorphic sarcomatoid carcinoma. During follow-up she developed an ampulla of Vater adenocarcinoma. Genetic analysis identified an MSH2 pathogenic variant. Conclusion: This case contributes to expand the tumour spectrum of Lynch syndrome, suggesting that MSH2 pathogenic variants cause a more complex multi-tumour cancer syndrome than the classic Lynch Syndrome. In MSH2 variant carriers, symptoms such as dyspnoea and chest discomfort might alert for rare tumours and a focused cardiac evaluation should be considered
Root and xylem anatomy varies with root length, root order, soil depth, and environment in intermediate wheatgrass (Kernza®) and alfalfa
No full textBACKGROUND AND AIMS: Deep roots (i.e., > 1 m depth) are important for crops to access water when the topsoil is dry. Root anatomy and hydraulic conductance play important roles in the uptake of soil water, particularly water located deep in the soil. We investigated whether root and xylem anatomy vary as a function of root type, order and length or with soil depth in roots of two deep-rooted perennial crops: intermediate wheatgrass (Thinopyrum intermedium (Kernza ®)) and alfalfa (Medicago sativa). We linked the expression of these anatomical traits to the plant's capacity to take up water from deep soil layers.METHODS: Using laser ablation tomography, we compared the roots of the two crops for cortical area, number and size of metaxylem vessels and their Estimated Root Axial Hydraulic Conductance (ERAHCe). The deepest roots investigated were located at soil depths of 2.25 and at 3.5 m in the field and in rhizoboxes, respectively. Anatomical differences were characterized along 1-m long individual roots, among root types and orders as well as between environmental conditions.KEY RESULTS: For both crops, a decrease in the number, diameter, or both, of metaxylem vessels along individual root segments and with soil depth in the field resulted in a decrease in ERAHCe. Alfalfa, with a greater number of metaxylem vessels per root throughout the soil profile and, on average, a 4-fold greater ERAHCe, took up more water from the deep soil layers than intermediate wheatgrass. Root anatomical traits were significantly different across root types, classes and growth conditions.CONCLUSIONS: Root anatomical traits are important tools for the selection of crops with enhanced exploitation of deep soil water. The development and breeding of perennial crops for improved subsoil exploitation will be aided by greater understanding of root phenotypes linked to deep root growth and activity.</p
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