40 research outputs found
Hardness-and-Type Recognition of Different Objects Based on a Novel Porous Graphene Flexible Tactile Sensor Array
No full textAccurately recognizing the hardness and type of different objects by tactile sensors is of great significance in human–machine interaction. In this paper, a novel porous graphene flexible tactile sensor array with great performance is designed and fabricated, and it is mounted on a two-finger mechanical actuator. This is used to detect various tactile sequence features from different objects by slightly squeezing them by 2 mm. A Residual Network (ResNet) model, with excellent adaptivity and feature extraction ability, is constructed to realize the recognition of 4 hardness categories and 12 object types, based on the tactile time sequence signals collected by the novel sensor array; the average accuracies of hardness and type recognition are 100% and 99.7%, respectively. To further verify the classification ability of the ResNet model for the tactile feature information detected by the sensor array, the Multilayer Perceptron (MLP), LeNet, Multi-Channel Deep Convolutional Neural Network (MCDCNN), and ENCODER models are built based on the same dataset used for the ResNet model. The average recognition accuracies of the 4hardness categories, based on those four models, are 93.6%, 98.3%, 93.3%, and 98.1%. Meanwhile, the average recognition accuracies of the 12 object types, based on the four models, are 94.7%, 98.9%, 85.0%, and 96.4%. All of the results demonstrate that the novel porous graphene tactile sensor array has excellent perceptual performance and the ResNet model can very effectively and precisely complete the hardness and type recognition of objects for the flexible tactile sensor array
Weak Mesoscale Variability in the Optimum Interpolation Sea Surface Temperature (OISST)-AVHRR-Only Version 2 Data before 2007
No full textMesoscale sea surface temperature (SST) variability triggers mesoscale air–sea interactions and is linked to ocean subsurface mesoscale dynamics. The National Oceanic and Atmospheric Administration (NOAA) daily Optimum Interpolation SST (OISST) products, based on various satellite and in situ SST data, are widely utilized in the investigation of multi-scale SST variabilities and reconstruction of subsurface and deep-ocean fields. The quality of OISST datasets is subjected to temporal inhomogeneity due to alterations in the merged data. Yet, whether this issue can significantly affect mesoscale SST variability is unknown. The analysis of this study detects an abrupt enhancement of mesoscale SST variability after 2007 in the OISST-AVHRR-only version 2 and version 2.1 datasets (hereafter OI.v2-AVHRR-only and OI.v2.1-AVHRR-only). The contrast is most stark in the subtropical western boundary current (WBC) regions, where the average mesoscale SST variance during 2007–2018 is twofold larger than that during 1993–2006. Further comparisons with other satellite SST datasets (TMI, AMSR-E, and WindSAT) suggest that the OISST-AVHRR-only datasets have severely underestimated mesoscale SST variability before 2007. An evaluation of related documents of the OISST data indicates that this bias is mainly caused by the change of satellite AVHRR instrument in 2007. There are no corresponding changes detected in the associated fields, such as the number and activity of mesoscale eddies or the background SST gradient in these regions, confirming that the underestimation of mesoscale SST variability before 2007 is an artifact. Another OISST product, OI.v2-AVHRR-AMSR, shows a similar abrupt enhancement of mesoscale SST variability in June 2002, when the AMSR-E instrument was incorporated. This issue leaves potential influences on scientific research that utilize the OISST datasets. The composite SST anomalies of mesoscale eddies based on the OI.v2-AVHRR-only data are underestimated by up to 37% before 2007 in the subtropical WBC regions. The underestimation of mesoscale variability also affects the total (full-scale) SST variability, particularly in winter. Other SST data products based on the OISST datasets were also influenced; we identify suspicious changes in J-OFURO3 and CFSR datasets; the reconstructed three-dimensional ocean products using OISST data as input may also be inevitably affected. This study reminds caution in the usage of the OISST and relevant data products in the investigation of mesoscale processes
Contact Pattern Recognition of a Flexible Tactile Sensor Based on the CNN-LSTM Fusion Algorithm
No full textRecognizing different contact patterns imposed on tactile sensors plays a very important role in human–machine interaction. In this paper, a flexible tactile sensor with great dynamic response characteristics is designed and manufactured based on polyvinylidene fluoride (PVDF) material. Four contact patterns (stroking, patting, kneading, and scratching) are applied to the tactile sensor, and time sequence data of the four contact patterns are collected. After that, a fusion model based on the convolutional neural network (CNN) and the long-short term memory (LSTM) neural network named CNN-LSTM is constructed. It is used to classify and recognize the four contact patterns loaded on the tactile sensor, and the recognition accuracies of the four patterns are 99.60%, 99.67%, 99.07%, and 99.40%, respectively. At last, a CNN model and a random forest (RF) algorithm model are constructed to recognize the four contact patterns based on the same dataset as those for the CNN-LSTM model. The average accuracies of the four contact patterns based on the CNN-LSTM, the CNN, and the RF algorithm are 99.43%, 96.67%, and 91.39%, respectively. All of the experimental results indicate that the CNN-LSTM constructed in this paper has very efficient performance in recognizing and classifying the contact patterns for the flexible tactile sensor
Supplementing Genistein for Breeder Hens Alters the Growth Performance and Intestinal Health of Offspring
No full textRecent research revealed that dietary genistein supplementation for breeder hens can improve the immune function of offspring chicks. However, it remains unknown whether this maternal effect could improve the intestinal health of offspring. This study was conducted to explore the mechanism involved in the maternal effect of genistein on the intestinal mucosa and microbial homeostasis of chicken offspring. A total of 120 Qiling breeder hens were fed a basal diet, a 20 mg/kg genistein-supplemented diet, or a 40 mg/kg genistein-supplemented diet for 4 weeks before collecting their eggs. After hatching, 180 male offspring (60 chickens from each group) were randomly selected and divided into three groups: (1) the offspring of hens fed a basal diet (CON); (2) the offspring of hens fed a low-dose genistein-supplemented diet (LGE); (3) the offspring of hens fed a high-dose genistein-supplemented diet (HGE). At 17 d, 72 male offspring (48 chickens from CON and 24 chickens from LGE) were divided into three groups: (1) the offspring of hens fed a basal diet (CON); (2) the CON group challenged with LPS (LPS); (3) the LGE group challenged with LPS (LPS + LGE). The results showed that maternal genistein supplementation increased the birth weight and serum level of total protein (TP), followed by improved intestinal villus morphology. Continuously, the maternal effect on the body weight of chicks lasted until 21 d. Additionally, it was observed that maternal genistein supplementation exhibited protective effects against LPS-induced morphological damage and intestinal mucosal barrier dysfunction by upregulating the expression of tight junction proteins, specifically ZO-1, Claudin1, E-cadherin, and Occludin, at 21 d. Using 16S rRNA gene sequencing, we demonstrated that maternal supplementation of genistein has the potential to facilitate the maturation of newly hatched chicken offspring by enhancing the abundance of Escherichia coli. Additionally, maternal genistein supplementation can effectively reduce the abundance of Gammaproteobacteria, thus mitigating the risk of bacterial diversity impairment of LPS. In light of these findings, maternal genistein supplementation holds promise as a potential strategy for ameliorating intestinal mucosal damage and modulating the microbiome in chicken offspring
Techno-economic assessment of photovoltaic power generation mounted on cooling towers
No full textThe deployment of photovoltaic systems based on existing buildings has been the focus of research in recent years. It is necessary to evaluate the techno-economic performance of the new photovoltaic system deployment strategy for its actual implementation. In this paper, we comprehensively evaluated the power generation potential and economic performance of photovoltaics deployed on hyperbolic cooling towers in Mainland China. Based on the local solar radiation situations and electricity prices, we analyzed both the technical and economic performance of cooling towers photovoltaic (CT-PV) located in different cities. The results show that the total capacity of photovoltaic installations on all cooling towers reaches 1.05 GW, with corresponding annual power generation of 1.44 TWh. The total CO2 emission reduction and total profit by CT-PV cooling towers photovoltaic over a lifetime of 25 years can reach 31 Mts and 8.00 billion CNY, respectively. The return on investment is between 1.1 and 2.49, depending on the location. The payback period for all cities is less than 8 years, and around 90% of the cities’ solar generation electricity prices are below 0.35 CNY/kWh, which can compete with the benchmark price of coal-fired electricity. These results reveal that CT-PVs cooling towers photovoltaics have significant potential for PV photovoltaic application with attractive energy and economic benefits.</p
14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells.
No full textThe 14-3-3 proteins are a family of regulatory signaling molecules that interact with other proteins in a phosphorylation-dependent manner and function as adapter or scaffold proteins in signal transduction pathways. One family member, 14-3-3ζ, is believed to function in cell signaling, cycle control, and apoptotic death. A systematic proteomic analysis done in our laboratory has identified signal transducers and activators of transcription 3 (Stat3) as a novel 14-3-3ζ interacting protein. Following our initial finding, in this study, we provide evidence that 14-3-3ζ interacts physically with Stat3. We further demonstrate that phosphorylation of Stat3 at Ser727 is vital for 14-3-3ζ interaction and mutation of Ser727 to Alanine abolished 14-3-3ζ/Stat3 association. Inhibition of 14-3-3ζ protein expression in U266 cells inhibited Stat3 Ser727 phosphorylation and nuclear translocation, and decreased both Stat3 DNA binding and transcriptional activity. Moreover, 14-3-3ζ is involved in the regulation of protein kinase C (PKC) activity and 14-3-3ζ binding to Stat3 protects Ser727 dephosphorylation from protein phosphatase 2A (PP2A). Taken together, our findings support the model that multiple signaling events impinge on Stat3 and that 14-3-3ζ serves as an essential coordinator for different pathways to regulate Stat3 activation and function in MM cells
Effects of Dietary Supplemental Chlorogenic Acid and Baicalin on the Growth Performance and Immunity of Broilers Challenged with Lipopolysaccharide
No full textThe objective of this study was to investigate the effects of dietary supplemental chlorogenic acid and baicalin (CAB) on the growth performance and immunity of broilers challenged with lipopolysaccharide (LPS). This study was designed as a factorial arrangement of 2 dietary CAB treatments × 2 LPS treatments. Birds challenged with or without LPS were fed with a basic diet (CON) and (LPS), the level of CAB diet containing 500 mg/kg CAB(CAB) and (CAB + LPS). The feeding trial lasted for 42 days. Results showed that there was a negative effect on average daily weight gain (ADG) and average body weight of broilers during the animal trial with LPS challenge. The levels of diamine oxidase (DAO), lysozyme (LYZ), immunoglobulin G (IgG), and IgA in the serum, the contents of IL-1β and TNF-α in the spleen were elevated with LPS treated. Additionally, LPS treatment tended to reduce the jejunal villi height (VH) and total superoxide dismutase (T-SOD) in the serum. Dietary supplemental 500 mg/kg CAB increased the body weight and ADG and improved the feed conversion ratio (FCR) during the trial period. In addition, dietary 500 mg/kg CAB elevated the ratio of VH to crypt depth in the jejunum and reduced the content of protein carbonyl. Beyond that, the levels of IgG and IgA in the serum and transforming growth factor (TGF-β) in the spleen were up-regulated with 500 mg/kg CAB supplementation. In conclusion, dietary CAB was beneficial for growth performance and immunity of broilers challenged with lipopolysaccharide
Dietary N-acetylcysteine supplementation improves antioxidant capacity and production performance of breeder hens and offspring
No full textThis study investigated the effects of dietary N-acetylcysteine (NAC) supplementation on the antioxidant capacity and production performance of broiler breeder hens and their offspring. The breeder hens were randomly assigned to two groups: one received a corn-soybean meal-based control diet, while the other was supplemented with 1 g/kg NAC. Eggs from each group were randomly selected for incubation, and the offspring broilers were fed a basal diet. Dietary NAC treatment not only increased the albumen height and Haugh unit values of eggs but also improved fertilization rates (P < 0.05). Additionally, broiler chicks from the NAC-treated hens demonstrated higher eviscerated weight, full evisceration rate, and semi-eviscerated weight (P < 0.05). Dietary supplementation with NAC in breeder hens enhanced antioxidant capacity, as evidenced by increased total antioxidant capacity and catalase (CAT) activity in egg yolk, elevated CAT and glutathione peroxidase activities in breeder hen serum, and higher superoxide dismutase activity in chick serum. In particular, the NAC-treated group showed significantly higher glutathione levels and lower malondialdehyde levels throughout the transition from breeder hens to offspring (P < 0.05). Furthermore, maternal NAC treatment decreased the relative mRNA expression levels of pro-inflammatory cytokines interferon-γ, interleukin 18, and interleukin 6 in the ileum of the offspring broilers (P < 0.05). In conclusion, maternal dietary supplementation with NAC can continuously enhance the antioxidant capability and intestinal barrier function of chicken offspring, while also improving egg quality, growth performance and slaughter performance
Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke
No full textBackground/Aims: Stroke is a major cerebrovascular disease threatening human health and life with high morbidity, disability and mortality. It is aimed to find effective biomarkers for the early diagnosis on stroke. Methods: The expressions of 17 previously reported stroke-associated miRNAs were measured using quantitative RT-PCR and the expressions of plasma high-sensitivity C reactive protein (hs-CRP) and serum interleukin 6 (IL-6), the pro-inflammation markers in brain injury, were examined using enzyme-linked immunosorbent assay in 128 acute ischemic stroke (AIS) patients and control group. Results: Serum miR-146b expression was significantly increased within 24 hours after stroke onset in patients compared with control group. In addition, the upregulation of serum miR-146b was strong positively correlated with plasma hs-CRP, infarct volume and National Institutes of Health Stroke Scale (NIHSS) score, and moderate positively correlated with serum IL-6 of patients. Importantly, the combination of plasma hs-CRP and serum miR-146b gained a better sensitivity/specificity for prediction of AIS (AUC from 0.782 to 0.863). Conclusion: Our preliminary findings suggested that upregulated serum miR-146b in acute ischemic stroke might be a potential biomarker for AIS evaluation.</jats:p
Association between Helicobacter pylori Infection and Diabetes: A Cross-Sectional Study in China
No full textBackground. Studies suggest an association between H. pylori infection and extragastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes in a large health checkup population in China. Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included. H. pylori infection was diagnosed by 13C-urea breath test. Multivariate logistic regression analysis was performed to evaluate the association between H. pylori infection and diabetes. Results. The mean age of 13,397 participants was 43.8±12 years. The prevalence of H. pylori infection and diabetes was 28.2% and 8.1%, respectively. The prevalence of diabetes was higher among H. pylori-positive participants compared with their counterparts (8.9% vs 7.8%, p=0.05). After adjustment of age, sex, family history of diabetes, smoking, education, stroke, coronary heart disease, BMI, SBP, TG, HDL-C, and LDL-C, multivariate logistic regression analysis found no association between H. pylori infection and diabetes (OR 1.02, 95% CI 0.88-1.18). Additionally, subgroup analysis indicated that H. pylori infection was significantly associated with increased risk of diabetes in the female group (OR 1.09, 95% CI 1.08-1.09). Conclusions. No significant association was found between H. pylori infection and diabetes. However, the subgroup analysis suggested that H. pylori infection was possibly associated with increased risk of diabetes among females. Future cohort studies are needed to verify this association in females and to address possible implication in the prevention of diabetes
