177,918 research outputs found
Generalized Luscher's formula in multichannel baryon-baryon scattering
No full textIn this paper, Luscher's formula is generalized to the case of two spin-1/2 particles in two-channel scattering based on our previous work [Phys. Rev. D 87, 014502 (2013)]. This is first done in a nonrelativistic quantum mechanics model and then generalized to the quantum field theory. We show that Luscher's formulas obtained from these two different methods are equivalent up to terms that are exponentially suppressed in the box size. This formalism can be readily applied to future lattice QCD calculations in nucleon-nucleon or nucleon-hyperon scattering processes.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341287600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Astronomy & AstrophysicsPhysics, Particles & FieldsSCI(E)[email protected]
Utilisation en psychologie clinique du test de choix de couleurs (Luscher)
No full textDounovetz A., Durand de Bousingen R. Utilisation en psychologie clinique du test de choix de couleurs (Luscher). In: Bulletin de la Société française du Rorschach et des méthodes projectives, n°23, 1969. Psycholinguistique et techniques projectives. pp. 95-98
Endothelial dysfunction, hypertension and atherosclerosis: A review of the effects of lacidipine
No full textLacidipine, a third generation dihydropyridine calcium antagonist, has demonstrated pronounced anti-atherosclerotic activity in preclinical studies. The drug can act at several stages within the atherosclerotic process, utilising its anti-hypertensive and antioxidant properties to protect hypertensive animals against mortality and vascular damage, to reduce cholesterol levels from the vessel wall of hypercholesterolaemic animals, and to reduce the progression of existing atherosclerotic lesions. The clinical benefit of lacidipine in atherosclerosis has recently been confirmed in humans in a large, multicentre, comparative, 4-year clinical trial involving patients with mild to moderate hypertension. The European Lacidipine Study on Atherosclerosis (ELSA) showed that lacidipine was able to slow the progression of atherosclerosis, measured as carotid intimato-media thickness, by 40% compared with atenolol (p = 0.0073). Although further comparative trials are needed, based on the results of ELSA, lacidipine is likely to become a promising therapeutic agent for atherosclerosis
The new postgraduate course in heart failure (PCHF): update on 1st PCHF and announcement of the 2nd PCHF. A project of the European Society of Cardiology Heart Failure Association, the ESC European Heart Academy, the Zurich Heart House and the University of Zurich
No full textAppropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Transient rhythmic network activity in the somatosensory cortex evoked by distributed input in vitro
No full textThe initiation and maintenance of physiological and pathophysiological oscillatory activity depends on the synaptic interactions within neuronal networks. We studied the mechanisms underlying evoked transient network oscillation in acute slices of the adolescent rat somatosensory cortex and modeled its underpinning mechanisms. Oscillations were evoked by brief spatially distributed noisy extracellular stimulation, delivered via bipolar electrodes. Evoked transient network oscillation was detected with multi-neuron patch-clamp recordings under different pharmacological conditions. The observed oscillations are in the frequency range of 2-5 Hz and consist of 4-12 mV large, 40-150 ms wide compound synaptic events with rare overlying action potentials. This evoked transient network oscillation is only weakly expressed in the somatosensory cortex and requires increased [K+]o of 6.25 mM and decreased [Ca2+]o of 1.5 mM and [Mg2+]o of 0.5 mM. A peak in the cross-correlation among membrane potential in layers II/III, IV and V neurons reflects the underlying network-driven basis of the evoked transient network oscillation. The initiation of the evoked transient network oscillation is accompanied by an increased [K+]o and can be prevented by the K+ channel blocker quinidine. In addition, a shift of the chloride reversal potential takes place during stimulation, resulting in a depolarizing type A GABA (GABAA) receptor response. Blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-proprionate (AMPA), N-methyl-D-aspartate (NMDA), or GABA(A) receptors as well as gap junctions prevents evoked transient network oscillation while a reduction of AMPA or GABA(A) receptor desensitization increases its duration and amplitude. The apparent reversal potential of -27 mV of the evoked transient network oscillation, its pharmacological profile, as well as the modeling results suggest a mixed contribution of glutamatergic, excitatory GABAergic, and gap junctional conductances in initiation and maintenance of this oscillatory activity. With these properties, evoked transient network oscillation resembles epileptic afterdischarges more than any other form of physiological or pathophysiological neocortical oscillatory activity
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Letter from R. R. Zellick, Assistant Trust Officer, Anglo California National Bank of San Francisco, to Joseph R. Goodman, October 2, 1942
No full textLetter from R. R. Zellick, Assistant Trust Officer at The Anglo California National Bank of San Francisco, to Joseph R. Goodman, regarding property owned by Dave Tatsuno. Zellick mentions a dispute between current tenants and Tatsuno, and that Tatsuno has asked Goodman to help locate trustworthy tenants.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Prolyl-isomerase-1 (pin1) mediates hyperglycemia-induced oxidative stress, endothelial function and vascular inflammation: insights in patients with type 2 diabetes
No full textPurpose: Prolyl-isomerase-1 (Pin1) regulates function of protein substrates through isomerization of peptide bonds that link phosphoserine or phosphothreonine to proline. Pin1 triggers reactive oxygen species (ROS) production and inflammation in human cancer. Whether Pin1 is involved in cardiovascular disease remains largely unknown. This study investigates the role of Pin1 in diabetes-related vascular dysfunction.
Methods: Human aortic endothelial cells (HAECs) were exposed to normal (NG, 5mmol/L) or high glucose concentrations (HG, 25 mmol/L) in the presence or in the absence of Pin1 pharmacological inhibitor Juglone or siRNA-mediated knockdown. Diabetes was induced in C57/B6 male mice (aged 4-6 months) by streptozocin and animals were treated i.v. with Pin1 siRNA or Juglone i.p for 30 days. Endothelial function was assessed by dose-response curve with acetylcoline. Protein expression was assessed by immunoblotting. Mitochondrial ROS were measured by ESR spectroscopy. Immunoprecipitation was performed to show the interaction of Pin1 with phosphorylated p66Shc and NFkB subunit p65. In parallel, Pin1 gene expression was assessed in peripheral blood monocytes (PBM) of 30 patients with type 2 diabetes (T2DM) and 18 healthy age-matched controls and correlated with flow-mediated vasodilation (FMD) of the brachial artery, urinary 8-isoprostaglandinF2α (8-isoPGF2α) as a marker of oxidative stress, and plasma adhesion molecules VCAM-1, ICAM-1 and MCP-1.
Results: Pin1 expression markedly increased in HAECs exposed to HG (289±22% vs NG, p<0.01) and aortas of diabetic mice (216±32% vs controls, p<0.05). Immunoprecipitation showed that Pin1 recognizes phosphoserine motifs of the pro-oxidant mitochondrial adaptor p66Shc as well as NFkB subunit p65. Interestingly, Juglone or Pin1siRNA prevented p66Shc-induced ROS production and suppressed upregulation of adhesion molecules VCAM-1, ICAM-1 and MCP-1 via inhibition of p65 nuclear translocation. In vivo knockdown of Pin1 or Juglone in diabetic mice protected against hyperglycemia-induced endothelial dysfunction, ROS production and vascular inflammation. Of note, Pin1 mRNA was significantly upregulated in PBM of T2DM patients as compared with healthy controls (370±97 vs. 25±28, p<0.01) and correlated with glycated haemoglobin (r=0.44, p<0.05), FMD (r=-0.36,p<0.01), urinary 8-isoPGF2α (r=0.39, p<0.05), as well as VCAM-1 (r=0.56, p<0.05) and ICAM-1 (r=0.53, p<0.05).
Conclusions: This study shows for the first time that Pin1 may critically contribute to oxidative stress, endothelial dysfunction and vascular inflammation in patients with type 2 diabetes
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