117,688 research outputs found
L’ influenza del grado di insaturazione sulle macrociclizzazioni: sintesi di diarileptanoidi ciclici
No full textPlasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction
No full textAcute phase reaction (APR) is a systemic inflammation triggered by several conditions associated with lipid profile alterations. We evaluated whether APR also associates with changes in cholesterol synthesis and absorption, HDL structure, composition, and cholesterol efflux capacity (CEC). We analyzed 59 subjects with APR related to infections, oncologic causes, or autoimmune diseases and 39 controls. We detected no difference in markers of cholesterol synthesis and absorption. Conversely, a significant reduction of LpA-I- and LpAI:AII-containing HDL (28% and 44.8%, respectively) and of medium-sized HDL (10.5%) occurred in APR. Total HDL CEC was impaired in APR subjects (18%). Evaluating specific CEC pathways, we found significant reductions in CEC by aqueous diffusion and by the transporters scavenger receptor B-I and ABCG1 (25.5, 41.1 and 30.4%, respectively). ABCA1-mediated CEC was not affected. Analyses adjusted for age and gender provided similar results. In addition, correcting for HDL-cholesterol (HDL-C) levels, the differences in aqueous diffusion total and ABCG1-CEC remained significant. APR subjects displayed higher levels of HDL serum amyloid A (+20-folds; P = 0.003). In conclusion, APR does not associate with cholesterol synthesis and absorption changes but with alterations of HDL composition and a marked impairment of HDL CEC, partly independent of HDL-C serum level reduction.—Zimetti, F., S. De Vuono, M. Gomaraschi, M. P. Adorni, E. Favari, N. Ronda, M. A. Ricci, F. Veglia, L. Calabresi, and G. Lupattelli. Plasma cholesterol homeostasis, HDL remodeling and function during the acute phase reaction
Regarding “Cutting balloon angioplasty of renal fibromuscular dysplasia: A word of caution”
No full textNo abstract is available for this article
Imaging evaluation of post pancreatic surgery
No full textThe role of several imaging techniques in patients submitted to pancreatic surgery with special emphasis to single-slice helical computed tomography (CT) and multidetector-row CT (MDCT) was reviewed. Several surgical options may be performed such as Whipple procedure, distal pancreatectomy, central pancreatectomy, and total pancreatectomy. Ultrasound examination may be used to detect peritoneal fluid in the early post-operative period as well as lesion recurrence in long-term follow-up. Radiological gastrointestinal studies has a major role in evaluation of intestinal functionality. In spite of the advent of other imaging modalities, CT is the most effective after pancreatic surgery. On post-operative CT, the most common findings were small fluid peritoneal or pancreatic collections, stranding of the mesenteric fat with perivascular cuffing, reactive adenopathy and pneumobilia. In addition, CT may demonstrate early (leakage of anastomosis, pancreatico-jejunal fistula, haemorrage, acute pancreatitis of the remnant pancreas, peritonitis), and late (chronic fistula, abscess, aneurysms, anastomotic bilio-digestive stenosis, perianastomotic ulcers, biloma, and intra-abdominal bleeding) surgical complications. In the follow-up evaluation, CT may show tumor recurrence, liver and lymph nodes metastasis. Magnetic resonance may be used as alternative imaging modality to CT, when renal insufficiency or contrast sensitivity prevents the use of iodinated i.v. contrast material or when the biliary tree study is primarily requested. The knowledge of the type of surgical procedures, the proper identification of the anastomoses as well as the normal post-operative imaging appearances are essential for an accurate detection of the complications and recurrent disease
Recent Advances in Synthetic Strategies to 2,3-Dihydrobenzofurans
No full textThis review gives an overview on recent developments in methods for the construction of compounds with the 2,3-dihydrobenzo furan core in the period 2012 to 2019. Interest in 2,3-dihydrobenzofurans is constantly increasing. The methods are divided into intermolecular and intramolecular approaches. Intermolecular approaches are subdivided according to the parent intermediate for the key reaction, while intermolecular approaches are subdivided according by which bond is formed in the key reaction. The transformation of benzofurans to dihydrobenzofurans and other miscellaneous methods are also discussed. Approaches useful for the synthesis of natural products are emphasized. 1 Introduction 2 Intermolecular Approaches 2.1 o -Quinone Methides and o -Quinones 2.2 p -Quinone Methides and p -Quinones 2.3 Nitrogen-Containing Phenols and Quinones 2.4 o -Hydroxyphenylcarbonyl Derivatives and Phenols 2.5 Miscellaneous 3 Intramolecular Approaches 3.1 O-C2 Bond Forming 3.2 C2-C3 Bond Forming 3.3 C3-Aryl Bond Forming 3.4 O-Aryl Bond Forming 4 From BF to DHB 5 Rearrangements and Aromatizations
From trans 2,3-diaryloxiranes to trans 2,3-diaryl-2,3-dihydrobenzofurans:toward the synthesis of ε-Viniferin and Gnetin C
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Single route to chiral syn- and anti-2-amino-1,2-diphenylethanols via a new stereodivergent opening of trans-1,2-diphenyloxirane
No full textOxiranyl ring opening of trans-stilbene oxide gave rise to anti- or syn-2-bromo-1,2-diphenylethanols, using either MgBr2.Et2O or MgBr2.Et2O, NaBr, and KBr with Amberlyst 15, respectively. Starting from optically pure (R,R)-trans-stilbene oxide, (1R,2R)- and (1R,2S)-2-amino-1,2-diphenylethanols were obtained in high yield and ee
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