1,720,982 research outputs found
A Hierarchical, Modular Music Sequencer
No full textMusical structure is replete with hierarchy, modularity, reuse, and variation. We are interested in how these aspects of music may be employed in a tool for composition and performance. We describe an experimental music sequencer we have developed which is meant to help musicians build complex, highly modular, hierarchical musical structures. The musician begins with basic musical elements, then groups them into larger structures to combine them in a wide variety of ways. The same elements may be reused in many contexts, and may be parameterized and customized each time, creating variation. This sequencer is meant as both a composition and performance tool. We discuss past research in hierarchy and modularity in music, detail our sequencer approach, outline ways that it provides hierarchy and modularity, and discuss how we intend to use its basic model as a jumping-off point for introducing machine learning, optimization, and experimentation into the sequencing process
Development of methods to study oriented membrane proteins using synchrotron radiation circular dichroism spectroscopy
No full textMembrane proteins are important targets for structural biology. They account for a disproportionately large percentage of pharmacological targets, but only a minority of available protein structures. The intractability of membrane proteins to recombinant expression and purification has been a limiting factor in their structural characterisation. Of those structures available the majority rely on detergent solubilisation of the protein. This removes the native lipid environment which is established to have structural and functional implications. A number of techniques allow the investigation of membrane proteins in lipid bilayers which mimic the cellular membranes. In this thesis, two of these approaches, oriented synchrotron radiation circular dichroism (OSRCD) and solid-state nuclear magnetic resonance (NMR) spectroscopies have been used to investigate the orientation and structure of the transmembrane domain of a putative glycosyltransferase fukutin. We have developed a method for OSRCD based on the conventional means of sample preparation, where aligned bilayers are prepared on a support substrate. This allowed the orientation of the fukutin transmembrane domain to be determined in bilayers of different thickness which model membranes of different cellular compartments. Both OSRCD and NMR results indicate that the protein adapts by changing its tilt angle and forming large oligomers in thicker membranes, potentially providing a model for retention of fukutin in the thinner Golgi apparatus membranes, which appears to be essential for its function. As the preparation of well oriented samples can be challenging, a novel method of OSRCD using magnetic alignment of lipid phases has also been developed. The goal of this work was to align lipid phases in a magnetic SRCD instrument. Extensive characterisation of lipid mixtures using NMR, electron paramagnetic resonance and conventional CD enabled identification of conditions to allow alignment at low magnetic fields such as those found in magnetic SRCD instruments. Although OSRCD measurements on magnetically aligned samples were not successful, a number of further modifications are suggested which may allow sample alignment under different conditions. With a view to expansion of the oriented techniques to a more complex protein, attempts were made to express and purify the pore region of the voltage-gated potassium channel expressed by the human Ether-á-go-go related gene (hERG). hERG is a particularly important target for structural characterisation as it has proclivity for non-specific drug binding, which can block the channel and result in drug induced long-QT syndrome, a phenomenon affecting a large number of newly developed pharmaceuticals
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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