958 research outputs found
Adjusting PFS to meet different customer requirements
No full textDarbā tiek salīdzinātas divas pieejas standartizēta produkta ieviešanai un uzturēšanai: ● Produkta versijas pielāgošana visiem klientiem, ● Individuāli katram klientam izveidota un uzturēta versija. Autors detalizēti aplūko katru pieeju un izvērtē tās ieguvumus un trūkumus. Aplūkotās pieejas tiks skatītas reālas sistēmas Pensiju fonda sistēma (PFS) kontekstā. Pašreiz PFS lieto divi pensiju fondi Latvijā. Bakalaura darba izstrādes laikā autors ir projekta dalībnieks PFS ieviešanai trešajam pensiju fondam Latvijā.The paper compares two implementation and maintenance approaches of a standardized product: ● Customizing the product version for all customers, ● A version created and maintained individually for each client. The author views each approach in detail and evaluates its advantages and disadvantages. Approaches considered will be viewed in context of a real system Pension Fund System (PFS). Currently, PFS is used by two pension funds in Latvia. During the development of the bachelor's thesis, the author is a project participant for the introduction of PFS for the third pension fund in Latvia
Progression-free survival (PFS) relationships to serum free light chain (sFLC) evaluations.
No full text(A) PFS among patients with “highly abnormal” sFLC ratios (32, red lines, median PFS: 38 mo) compared to those with normal sFLC ratios (0.03–32, blue lines, median PFS: 29 mo). (B) PFS among patients with normal (blue, median PFS: 53 mo) or abnormal (red, median PFS: 42 mo) sFLC ratios after treatment, regardless of the response achieved. (C) PFS among patients that achieved complete response (CR) with normal (blue, median PFS: 60 mo) or abnormal (red, median PFS: 59 mo) sFLC ratios. (D) PFS among patients with absolute involved-sFLC levels <100 mg/L (blue, median PFS: 50 mo) or ≥100 mg/L (red, median PFS: 33 mo).</p
Panorama epidemiológico de las enfermedades metabólicas detectadas por tamiz en el estado de San Luis Potosí
No full textObjetivo: Analizar el panorama epidemiológico de las enfermedades metabólicas detectadas por tamiz (EMDT) hipotiroidismo congénito, fenilcetonuria, galactosemia, hiperplasia suprarrenal congénita, fibrosis quística y deficiencia de glucosa 6 fosfato, en el estado de San Luis Potosí (S.L.P.) durante el periodo de 2000 al 2018.
Material y métodos: Estudio cuantitativo y descriptivo, transversal retrospectivo observacional, se analizaron bases de datos secundarios con casos confirmados de las EMDT de S.L.P., se utilizaron el Software PASW Statistics 18 y ArcGis 10.0; se desarrolló estadística descriptiva y mapas de georreferenciación.
Resultados. Durante el periodo 2000-2018 en S.L.P., la máxima cobertura de tamizaje de recién nacidos fue de 67% con prueba de tamiz metabólico, la media de casos nuevos fueron 47 casos por año, distribuidos: Hipotiroidismo congénito 578 (65.6%), Hiperplasia suprarrenal congénita 287 (31.6%), Deficiencia de glucosa 6 fosfato (14) (1.5%), Fibrosis quística (2), (0.2%), Galactosemia (9) (1%), Fenilcetonuria (1) (0.1%).
La incidencia de EMDT fue de 253 casos por cada 10,000 nacidos, mientras que la prevalencia fue de 1,705 casos por cada 10,000 nacidos con predominio del hipotiroidismo congénito como principal enfermedad que se presentó.
Las mayores prevalencias fueron: Hipotiroidismo Congénito se encontró en Ciudad Valles, la Deficiencia de Glucosa 6 fosfato en Villa de Reyes, la Fibrosis Quística en Santa María del rio, la Hiperplasia Suprarrenal en Villa de Arriaga, la Galactosemia, en Aquismón y la Fenilcetonuria en Ébano.
Conclusiones: El comportamiento de EMDT es muy variado y poco frecuentes de presentarse en S.L.P. no se tiene cobertura de Tamiz de 100%Objective: To analyze the epidemiological panorama of metabolic diseases detected by screening (EMDT) congenital hypothyroidism, phenylketonuria, galactosemia, congenital adrenal hyperplasia, cystic fibrosis and glucose 6 phosphate deficiency, in the state of San Luis Potosí (SLP) during the period of 2000 to 2018.
Material and methods: Quantitative and descriptive, cross-sectional retrospective observational study, secondary databases were analyzed with confirmed cases of the EMDT of S.L.P., PASW Statistics 18 and ArcGis 10.0 Software were used; Descriptive statistics and georeferencing maps were developed.
Results. During the period 2000-2018 in PFS, the maximum coverage of newborn screening was 67% with a metabolic sieve test, the mean of new cases was 47 cases per year, distributed: Congenital hypothyroidism 578 (65.6%), Adrenal hyperplasia congenital 287 (31.6%), Glucose 6 phosphate deficiency (14) (1.5%), Cystic fibrosis (2), (0.2%), Galactosemia (9) (1%), Phenylketonuria (1) (0.1%).
The incidence of TDM was 253 cases per 10,000 births, while the prevalence was 1,705 cases per 10,000 births with a predominance of congenital hypothyroidism as the main disease that occurred.
The highest prevalences were: Congenital Hypothyroidism was found in Ciudad Valles, Glucose 6 phosphate Deficiency in Villa de Reyes, Cystic Fibrosis in Santa María del rio, Adrenal Hyperplasia in Villa de Arriaga, Galactosemia in Aquismón and Phenylketonuria in Ebano.
Conclusions: The behavior of EMDT is very varied and infrequent to appear in S.L.P. there is no 100% Sieve coverage.Grupos de la comunida
Usage of Plant Food Supplements (PFS) for weight control in six European countries: results from the PlantLIBRA PFS Consumer Survey 2011-2012
No full textBackground: Obesity is increasing worldwide and weight-control strategies, including the consumption of plant food supplements (PFS), are proliferating. This article identifies the herbal ingredients in PFS consumed for weight control and by overweight/obese dieters in six European countries, and explores the relationship between their consumption and their self-reported BMI. Methods: Data used were a subset from the PlantLIBRA PFS Consumer Survey 2011-2012, a retrospective survey of 2359 PFS consumers. The survey used a bespoke frequency-of-PFS-usage questionnaire. Analyses were performed in two consumer subsamples of 1) respondents taking the products for "body weight reasons", and 2) "dieters for overweight/obesity", to identify the herbal ingredients consumed for these reasons. The relationship between the 5 most consumed herbal ingredients and self-reported BMI in groups 1 and 2 is explored by comparing BMI proportions of consumers vs. non-consumers (using Chi-squared test). Results: 252 PFS (8.8 %) were consumed for "body weight reasons" (by 240 PFS consumers); 112 PFS consumers (4.8 %) were "dieting for overweight/obesity". Spain is the country where consuming herbal ingredients for body weight control and dieting were most popular. Artichoke was the most consumed herbal ingredient. Considering only the 5 top products consumed by those who responded "body weight", when using the total survey sample, a greater proportion of BMI ≥ 25 was observed among consumers of PFS containing artichoke and green tea as compared to non-consumers (58.4 % vs. 49.1 % and 63.2 % vs. 49.7 % respectively). Considering only the 5 top products consumed by "dieters" and using only the "dieters" sample, a lower proportion of BMI ≥ 25 was observed among pineapple-containing PFS consumers (38.5 % vs. 81.5 %); however, when using the entire survey sample, a greater proportion of BMI ≥ 25 was observed among artichoke-containing PFS consumers (58.4 % vs. 49.1 %). Conclusions: A comparison of results among the scarce publications evaluating the use of weight-loss supplements at the population level is limited. Nevertheless every hint is important in finding out which are the self-treatment strategies used by overweight/obese individuals in European countries. Although limited by a small sample size, our study represents a first attempt at analysing such data in six EU countries. Our findings should encourage the conduction of further studies on this topic, long-term and large sample-sized studies, ideally conducted in the general population.150,7932,288Q1Q1SCI
Progression-free survival (PFS) relationships to the absolute value of involved serum heavy-light chain (isHLC) and the ratio of highly abnormal sHLC (HA-sHLCr).
No full text(A) PFS among patients with absolute values of isHLC 50 g/L (red, median PFS: 35 mo). (B) PFS among patients with HA-sHLCr (73, red; median PFS: 29 mo) vs. those with normal sHLCr (0.29–73, blue; median PFS: 36 mo). (C) PFS among patients with after-treatment absolute values of isHLC ≥5 g/L (red, median PFS: 47 mo), regardless of the response achieved. (D) PFS among patients that achieved partial response (PR) after treatment with absolute values of isHLC ≥5 g/L red, median PFS: 28 mo).</p
Keys under doormats - mandating insecurity by requiring government access to all data and communications
No full textAbstract
Twenty years ago, law enforcement organizations lobbied to require data and communication services to engineer their products to guarantee law enforcement access to all data. After lengthy debate and vigorous predictions of enforcement channels “going dark,” these attempts to regulate the emerging Internet were abandoned. In the intervening years, innovation on the Internet flourished, and law enforcement agencies found new and more effective means of accessing vastly larger quantities of data. Today we are again hearing calls for regulation to mandate the provision of exceptional access mechanisms. In this report, a group of computer scientists and security experts, many of whom participated in a 1997 study of these same topics, has convened to explore the likely effects of imposing extraordinary access mandates.
We have found that the damage that could be caused by law enforcement exceptional access requirements would be even greater today than it would have been 20 years ago. In the wake of the growing economic and social cost of the fundamental insecurity of today’s Internet environment, any proposals that alter the security dynamics online should be approached with caution. Exceptional access would force Internet system developers to reverse “forward secrecy” design practices that seek to minimize the impact on user privacy when systems are breached.
The complexity of today’s Internet environment, with millions of apps and globally connected services, means that new law enforcement requirements are likely to introduce unanticipated, hard to detect security flaws. Beyond these and other technical vulnerabilities, the prospect of globally deployed exceptional access systems raises difficult problems about how such an environment would be governed and how to ensure that such systems would respect human rights and the rule of law
Strategic Use of Data Assimilation for Dynamic Data-Driven Simulation
No full textDynamic data-driven simulation (DDDS) incorporates real-time measurement data to improve simulation models during model run-time. Data assimilation (DA) methods aim to best approximate model states with imperfect measurements, where particle Filters (PFs) are commonly used with discrete-event simulations. In this paper, we study three critical conditions of DA using PFs: (1) the time interval of iterations, (2) the number of particles and (3) the level of actual and perceived measurement errors (or noises), and provide recommendations on how to strategically use data assimilation for DDDS considering these conditions. The results show that the estimation accuracy in DA is more constrained by the choice of time intervals than the number of particles. Good accuracy can be achieved without many particles if the time interval is sufficiently short. An over estimation of the level of measurement errors has advantages over an under estimation. Moreover, a slight over estimation has better estimation accuracy and is more responsive to system changes than an accurate perceived level of measurement errors.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.System EngineeringPolicy Analysi
Prognostic value of “New Staging System (NSS)” based on sFLCR and B2M for Overall Survival (OS) and Progression-Free Survival (PFS).
No full textPrognostic value of “New Staging System (NSS)” based on sFLCR and B2M for Overall Survival (OS) and Progression-Free Survival (PFS).</p
Univariate and multivariate analysis of prognostic factors for Overall Survival (OS) and Progression-free Survival (PFS) in patients with newly diagnosed MM (n = 180).
No full textUnivariate and multivariate analysis of prognostic factors for Overall Survival (OS) and Progression-free Survival (PFS) in patients with newly diagnosed MM (n = 180).</p
Dimensional Analysis under Linguistic Pythagorean Fuzzy Set
No full textDimensional analysis under linguistic Pythagorean fuzzy set (DA-LPFS) is a technique to handle qualitative (intangible) as well as the interactions between criteria, by combining dimensional analysis (DA) and Pythagorean fuzzy set (PFS) with linguistic variables. In this paper, a novel DA method is proposed for LPFSs based in a PFS extension, in order to consider the mutual relationship among criteria and handle qualitative (fuzzy) and quantitative (crisp) information usually involved in Multi-criteria decision making (MCDM) problems. Finally, DA-LPFS is applied to handle a case concerning the selection of CNC router to illustrate the applicability of the method
- …
